Recombinant Human IL-6R alpha Protein, CF 227-SR-025/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human IL-6R alpha Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $504.00Supplier Page View Company Product Page
Catalog Number227-SR-025/CF
SpeciesHuman
Size25 ug
FormatLyophilized from a 0.2 µm filtered solution in PBS
Source/Expression SystemSf 21 (baculovirus)-derived Recombinant Human IL-6R alpha Protein, CF
Molecule NameIL-6R alpha
NCBI Full Gene Nameinterleukin 6 receptor
NCBI Gene AliasesHIES5, IL6RA, IL6Q, IL6QTL, IL-6RA, gp80, CD126, IL6RQ, IL-6R-1, IL-1Ra, IL-6R
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 45-50 kDa, reducing conditions
Theoretical: 38 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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(1) Experimental and computational studies of IL-6 signaling in endothelial cells under hypoxia serum starvation conditionsCytokineNovember 1, 2025Min Song, Youli Wang, Brian H. Annex, Aleksander S. Popelwith different concentrations of IL-6 (Cat. 206-IL-200/CF, R&D system), or IL-6 combined with sIL-6R (227-SR-025/CF, R&D system) for different times, at the experiment time-points, cell supernatants were collected and

(2) Effects of Candidalysin Derived from Candida albicans on the Expression of Pro-Inflammatory Mediators in Human Gingival FibroblastsInternational journal of molecular sciencesFebruary 7, 2023Nishikawa Y, Tomotake Y, Kawano H, Naruishi K, Kido JI, Hiroshima Y, Murakami A, Ichikawa T, Yumoto H.

(3) New-Generation Heterocyclic Bis-Pentamethinium Salts as Potential Cytostatic Drugs with Dual IL-6R and Mitochondria-Targeting ActivityPharmaceuticsAugust 17, 2022Talianová V, Kejík Z, Kaplánek R, Veselá K, Abramenko N, Lacina L, Strnadová K, Dvořánková B, Martásek P, Masařík M, et al.

(4) Pleiotropic, Unique and Shared Responses Elicited by IL-6 Family Cytokines in Human Vascular Endothelial CellsInternational journal of molecular sciencesJanuary 27, 2022Lindkvist M, Zegeye MM, Grenegård M, Ljungberg LU.

(5) A single aromatic residue in sgp130Fc/olamkicept allows the discrimination between interleukin-6 and interleukin-11 trans-signalingiScienceNovember 19, 2021Juliane Lokau, Yvonne Garbers, Joachim Grötzinger, Christoph GarbersT102Y/Q113F,Conaris Research AG,N/A sgp130Fc T102Y/Q113F/N114L,Conaris Research AG,N/A sIL-6R,R&D Systems,Cat# 227-SR-025/CF sIL-11R,R&D Systems,Cat# 8895-MR-050 Turbofect,Thermo Fisher Scientific,Cat# R0532 Ionomycin,Thermo Fisher Scientific

(6) CaMKIIδ is upregulated by pro‐inflammatory cytokine IL‐6 in a JAK/STAT3‐dependent manner to promote angiogenesisThe FASEB JournalJune 18, 2021Brendan J. O'Brien, Harold A. Singer, Alejandro P. Adam, Roman G. Ginnanprotocol. Antibodies and Reagents. Recombinant human IL-6 (catalog no. 206-IL-050) and sIL-6R (catalog no. 227-SR-025/CF) were purchased from R&D Systems. Pharmalogocial JAK inhibitor ruxolitinib was purchased from Selleck

(8) IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndromeProceedings of the National Academy of Sciences of the United States of AmericaSeptember 8, 2020Kang S, Tanaka T, Inoue H, Ono C, Hashimoto S, Kioi Y, Matsumoto H, Matsuura H, Matsubara T, Shimizu K, et al.

(9) Treatment of type 2 diabetes with the designer cytokine IC7FcNatureOctober 1, 2019Findeisen M, Allen TL, Henstridge DC, Kammoun H, Brandon AE, Baggio LL, Watt KI, Pal M, Cron L, Estevez E, et al.

(10) Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 ReceptorInternational journal of molecular sciencesSeptember 5, 2019Aryappalli P, Shabbiri K, Masad RJ, Al-Marri RH, Haneefa SM, Mohamed YA, Arafat K, Attoub S, Cabral-Marques O, Ramadi KB, et al.

(11) IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesisThe Journal of biological chemistryMay 10, 2019McGregor NE, Murat M, Elango J, Poulton IJ, Walker EC, Crimeen-Irwin B, Ho PWM, Gooi JH, Martin TJ, Sims NA.

(12) Fungal metabolite (+)-terrein suppresses IL-6/sIL-6R-induced CSF1 secretion by inhibiting JAK1 phosphorylation in human gingival fibroblastsHeliyonNovember 1, 2018Yamamoto S, Omori K, Mandai H, Nakayama M, Nakagawa S, Kobayashi H, Kunimine T, Yoshimura H, Sakaida K, Sako H, et al.

(13) Presenilin 1 Regulates NF-κB Activation via Association with Breakpoint Cluster Region and Casein Kinase IIJournal of immunology (Baltimore, Md. : 1950)October 15, 2018Tanaka Y, Sabharwal L, Ota M, Nakagawa I, Jiang JJ, Arima Y, Ogura H, Okochi M, Ishii M, Kamimura D, et al.

(14) A bispecific antibody that targets IL-6 receptor and IL-17A for the potential therapy of patients with autoimmune and inflammatory diseasesThe Journal of biological chemistryJune 15, 2018Lyman M, Lieuw V, Richardson R, Timmer A, Stewart C, Granger S, Woods R, Silacci M, Grabulovski D, Newman R.

(15) Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesisAmerican journal of physiology. Cell physiologyMay 1, 2018Alsaffar H, Martino N, Garrett JP, Adam AP.357420010). Recombinant human VEGF-165 (catalog no. 293-VE-010), IL-6 (catalog no. 206-IL-050), and sIL-6R␣ (227-SR-025/CF) were from R&D Systems. Antibodies against STAT3 (catalog no. 8768S), pY705-STAT3 (catalog no. 9145S),

(17) SorLA in Interleukin-6 Signaling and TurnoverMolecular and cellular biologyJune 1, 2017Larsen JV, Petersen CM.

(18) COPD monocytes demonstrate impaired migratory abilityRespiratory researchMay 11, 2017Ravi AK, Plumb J, Gaskell R, Mason S, Broome CS, Booth G, Catley M, Vestbo J, Singh D.

(19) STAT3-induced WDR1 overexpression promotes breast cancer cell migrationCellular signallingNovember 1, 2016Lee JH, Kim JE, Kim BG, Han HH, Kang S, Cho NH.

(20) Involvement of Spinal IL-6 Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-AlphaThe Journal of neuroscience : the official journal of the Society for NeuroscienceSeptember 21, 2016König C, Morch E, Eitner A, Möller C, Turnquist B, Schaible HG, Ebersberger A.

Recombinant Human IL-6R alpha Protein, CF