Recombinant Human IL-1 beta/IL-1F2 Protein, CF 201-LB-005/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human IL-1 beta/IL-1F2 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $303.00Supplier Page View Company Product Page
Catalog Number201-LB-005/CF
Size5 ug (also 10 ug, 25 ug, 100 ug, 500 ug, 1000 ug)
ApplicationsBioactivity
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular Weight17 kDa
Conjugate/TagUnconjugated
SpeciesHuman
Molecule NameIL-1 beta/IL-1F2
Source/Expression SystemE. coli-derived Recombinant Human IL-1 beta/IL-1F2 Protein, CF
NCBI Full Gene Nameinterleukin 1 beta
NCBI Gene AliasesIL1F2, IL1-BETA, IL-1, IL1beta

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascadeNature CommunicationsApril 1, 2026Yan Xiong, Jaiprakash Sharma, Meggie N. Young, Wen Xiong, Ali Jazayeri, Karl F. Poncha, Ma. Xenia G. Ilagan, Qing Wang, Bei Gao, Hui Zheng, et al.410-MT-010), recombinant human TNFα protein (Cat# 210-TA-005) and recombinant human IL-1β/IL-1F2 protein (Cat# 201-LB-005/CF) were from R&D systems. DQ Green BSA (Cat #D12050) was from Life Technologies. Primers RT–qPCR primers

(2) Intermittent intra-articular delivery of FGF8b enhances cartilage homeostasis and attenuates osteoarthritis progressionJournal of Orthopaedic TranslationJanuary 13, 2026Xiuqin Peng, Jiaming Han, Yu Tian, Xiaohong Li, Xuanqi Zhang, Song Li, Jun Yang, Liang Chen, Siru Zhou, Nan Su, et al.FGF8b (100-25, PeproTech), and 25 ng/ml was used in the later experiments. The concentration of IL-1β (201-LB-005/CF, R&D Systems) used was 10 ng/ml. 2.8 Quantitative real-time PCR Total RNA was extracted from treated

(3) Candida albicans Enhances Protease Activity and Activates MyD88 ‐Dependent IL ‐1β Production in Human KeratinocytesMycosesNovember 26, 2025Jingyi Wang, Neil A. R. Gow, Matthew G. Brewerincluding 103 CFU of yeast or different concentrations (10, 100, or 1000 pg/mL) of recombinant IL‐1β (Cat # 201‐LB‐005/CF, R&D Systems) were introduced 48 h post‐differentiation. After 24 h of exposure, KC were harvested for

(4) Genetic ancestry shapes dengue virus infection in human skin explantsProceedings of the National Academy of Sciences of the United States of AmericaJuly 15, 2025Castanha PMS, Martí MM, Duangkhae P, Taddonio JM, Cooper KL, Wallace M, Kettenburg G, Erdos G, Chavva H, Alex A, et al.recombinant human IFN-α (PBL Assay Science, 11200-1), 50 ng of recombinant human IL-1β (R&D Systems, 201-LB-005-CF), 20 μg of neutralizing antibody to human type 1 IFN (PBL Assay Science, 39000-1), 30 ng of neutralizing

(5) The E3 ligase c-Cbl modulates microglial phenotypes and contributes to Parkinson's disease pathologyCell Death DiscovApril 17, 2025Shumin Deng, Zhiyuan Zhang, Lu Liu, Chen Xu, Di Zhang, Lin Dong, Chunyan Gao, Xiaomin Wang, Zheng Fanincubated overnight at 4°C with the following primary antibodies: anti-TH (T1299, Sigma), anti-IL-1β (201-LB-005/CF, R&D Systems), anti-iNOS (18985-1-AP, Proteintech), and anti-CD206 (18704-1-AP, Proteintech). The sections

(6) Migration arrest and transendothelial trafficking of human pathogenic-like Th17 cells are mediated by differentially positioned chemokinesNature communicationsFebruary 26, 2025Parween F, Singh SP, Kathuria N, Zhang HH, Ashida S, Otaizo-Carrasquero FA, Shamsaddini A, Gardina PJ, Ganesan S, Kabat J, et al.9124-IL-010; R&D Systems), IL-23 (20 ng/mL, Cat# 1290-IL-010/CF; R&D Systems), IL-1β (20 ng/mL Cat# 201-LB-005/CF; R&D Systems) and TNF-α (20 ng/mL Cat# 210-TA-005/CF; R&D Systems) in medium containing 10 ng/mL IL-7

(7) Core circadian transcription factor Bmal1 mediates β cell response and recovery from pro-inflammatory injuryiScienceNovember 15, 2024Rakshit K, Brown MR, Javeed N, Lee JH, Ordog T, Matveyenko AV.and immunohistochemistry. INS-1 832/13 cells were cultured in the presence or absence of 2 ng mL−1 of IL-1β (201-LB-005/CF; R&D Systems, Minneapolis, MN) in RPMI media with L-glutamine, 10% fetal bovine serum (FBS), 1 mM sodium

(8) Multi-omic Mapping of Human Pancreatic Islet Endoplasmic Reticulum and Cytokine Stress Responses Provides Type 2 Diabetes Genetic InsightsCell MetabolismNovember 5, 2024Eishani K. Sokolowski, Romy Kursawe, Vijay Selvam, Redwan M. Bhuiyan, Asa Thibodeau, Chi Zhao, Cassandra N. Spracklen, Duygu Ucar, Michael L. Stitzel11530037 Glutamax,Gibco,Cat# 35050061 Human recombinant Interleukin beta 1 (IL1β),R&D systems,Cat# 201-LB-005/CF Human recombinant Interferon gamma (IFNy),R&D systems,Cat# 285_IF-100/CF Thapsigargin,Cayman Chemicals,Cat#

(9) Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technologyProceedings of the National Academy of Sciences of the United States of AmericaMay 7, 2024Madasu C, Liao Z, Parks SE, Sharma KL, Bohren KM, Ye Q, Li F, Palaniappan M, Tan Z, Yuan F, et al.with small-molecule inhibitors at 2× concentration and then supplemented with IL-1β (R&D systems, #201-LB-005/CF) to the final concentration to 0.05 ng/mL for 3 h. Total RNAs were subsequently harvested by the RNeasy

(10) LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lungScience advancesMay 26, 2023Ma HY, Li Q, Wong WR, N'Diaye EN, Caplazi P, Bender H, Huang Z, Arlantico A, Jeet S, Wong A, et al.then stimulated with tumor necrosis factor–α (10 ng/ml; 210-TA-020/CF, R&D Systems), IL-1β (10 ng/ml; 201-LB-005/CF, R&D Systems), IL-6 (10 ng/ml; 7270-IL-010/CF, R&D Systems), IL-13 (10 ng/ml; 213-ILB-025/CF, R&D Systems),

(11) Interferon-gamma is quintessential for NOS2 and COX2 expression in ER(-) breast tumors that lead to poor outcomeCell death & diseaseMay 11, 2023Cheng RYS, Ridnour LA, Wink AL, Gonzalez AL, Femino EL, Rittscher H, Somasundaram V, Heinz WF, Coutinho L, Rangel MC, et al.

(12) Regulatory mechanisms of kaempferol on iNOS expression in RINm5F β-cells under exposure to interleukin-1βHeliyonApril 1, 2023Chang SY, Ko Y, Kim MJ.

(13) Role of pulmonary epithelial arginase-II in activation of fibroblasts and lung inflammagingAging cellApril 1, 2023Zhu C, Potenza DM, Yang Y, Ajalbert G, Mertz KD, von Gunten S, Ming XF, Yang Z.

(14) CAR-T cells targeting HLA-G as potent therapeutic strategy for EGFR-mutated and overexpressed oral canceriScienceMarch 17, 2023Lin YC, Hua CH, Lu HM, Huang SW, Chen Y, Tsai MH, Lin FY, Canoll P, Chiu SC, Huang WH, et al.Recombinant human IL-2,PeproTech,"Cat# AF-200-02,RRID: N/A" Recombinant Human IL-1 beta/IL-1F2 Protein,R&D Systems,"Cat# 201-LB-005/CF,RRID: N/A" CellTracker™ Green CMFDA Dye,Thermo Fisher Scientific,"Cat# C2925,RRID: N/A" Propidium iodide solution

(15) BCL-XL Overexpression Protects Pancreatic β-Cells against Cytokine- and Palmitate-Induced ApoptosisInternational journal of molecular sciencesMarch 16, 2023Perez-Serna AA, Dos Santos RS, Ripoll C, Nadal A, Eizirik DL, Marroqui L.

(16) Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cellsbioRxiv : the preprint server for biologyFebruary 13, 2023Parween F, Singh SP, Zhang HH, Kathuria N, Otaizo-Carrasquero FA, Shamsaddini A, Gardina PJ, Ganesan S, Kabat J, Lorenzi HA, et al.(20 ng/ml 9124-IL-010; R&D Systems), IL-23 (20 ng/ml, 1290-IL-010/CF; R&D Systems), IL-1β (20 ng/ml 201-LB-005/CF; R&D Systems) and TNF-α (20 ng/ml 210-TA-005/CF; R&D Systems) in media containing 10 ng/ml IL-7 (BT-007-010;

(17) Selective Transcription Factor Blockade Reduces Human Retinal Endothelial Cell Expression of Intercellular Adhesion Molecule-1 and Leukocyte BindingInternational journal of molecular sciencesFebruary 7, 2023Ma Y, Ashander LM, Appukuttan B, Ryan FJ, Tan ACR, Matthews JM, Michael MZ, Lynn DJ, Smith JR.

(18) Silencing miR-146a-5p Protects against Injury-Induced Osteoarthritis in MiceBiomoleculesJanuary 7, 2023Qin H, Wang C, He Y, Lu A, Li T, Zhang B, Shen J.

(19) RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytesInternational journal of biological sciencesJanuary 1, 2023Yoon DS, Kim EJ, Cho S, Jung S, Lee KM, Park KH, Lee JW, Kim SH.

(20) Tannic acid, an IL-1β-direct binding compound, ameliorates IL-1β-induced inflammation and cartilage degradation by hindering IL-1β-IL-1R1 interactionPloS oneJanuary 1, 2023Lee HR, Jeong YJ, Lee JW, Jhun J, Na HS, Cho KH, Kim SJ, Cho ML, Heo TH.

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10/31/2019R&D Systems 201-LB Is Bound by R&D Systems Antibody MAB201 Anonymous ReviewerRecombinant Human IL-1 beta (201-LB, R&D Systems) is useful in binding assays and can likely be used in cellular assays as well.

IL-1 beta/IL-1F2 Protein

IL-1 beta/IL-1F2 Protein

IL-1 beta/IL-1F2 Protein

IL-1 beta/IL-1F2 Protein

IL-1 beta/IL-1F2 Protein

Recombinant Human IL-1 beta/IL-1F2 Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human IL-1 beta/IL-1F2 Protein, CF from R&D Systems, a Bio-Techne Brand

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