PDGF-BB Protein 520-BB-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemPDGF-BB Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $362.00Supplier Page View Company Product Page
Catalog Number520-BB-050
SpeciesRat
Size50 ug
Molecule NamePDGF-BB
NCBI Full Gene Nameplatelet derived growth factor subunit B
NCBI Gene AliasesSIS, IBGC5, c-sis, SSV, PDGF-2, PDGF2
FormatLyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA with BSA as a carrier protein
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular Weight25 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Rat PDGF-BB Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 50 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Sigma-1 Receptor Agonist Fluvoxamine Ameliorates Fibrotic Response of Trabecular Meshwork CellsInternational journal of molecular sciencesJuly 19, 2023Hodrea J, Tran MN, Besztercei B, Medveczki T, Szabo AJ, Őrfi L, Kovacs I, Fekete A.

(2) Combination of PDGF-BB and adipose-derived stem cells accelerated wound healing through modulating PTEN/AKT pathwayInjuryFebruary 13, 2023Lai F, Dai S, Zhao Y, Sun Y.

(3) Ant-Neointimal Formation Effects of SLC6A6 in Preventing Vascular Smooth Muscle Cell Proliferation and Migration via Wnt/β-Catenin SignalingInternational journal of molecular sciencesFebruary 3, 2023Rong Z, Li F, Zhang R, Niu S, Di X, Ni L, Liu C.

(4) Integrin β1, PDGFRβ, and type II collagen are essential for meniscus regeneration by synovial mesenchymal stem cells in ratsScientific reportsAugust 19, 2022Kitahashi T, Kogawa R, Nakamura K, Sekiya I.

(5) Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healingCell reportsAugust 16, 2022Yao L, Rathnakar BH, Kwon HR, Sakashita H, Kim JH, Rackley A, Tomasek JJ, Berry WL, Olson LE.

(6) Smad2 inhibition of MET transcription potentiates human vascular smooth muscle cell apoptosisAtherosclerosis PlusApril 21, 2022Xiujie Xie, Takuro Shirasu, Lian-Wang Guo, K. Craig KentRecombinant Human TGFβ1 was purchased from Thermo Fisher Scientific (PHG9214). Recombinant Human PDGF-BB (520BB050) was from R&D Systems (Minneapolis, M). Cell Titer-Glo 2.0 Assay kit was purchased from Promega (G9242).

(7) Recombinant platelet-derived growth factor-BB alleviates osteoarthritis in a rat model by decreasing chondrocyte apoptosis in vitro and in vivoJournal of cellular and molecular medicineAugust 1, 2021Zhu P, Wang Z, Sun Z, Liao B, Cai Y.

(8) Endosomal mTORC2 Is Required for Phosphoinositide-Dependent AKT Activation in Platelet-Derived Growth Factor-Stimulated Glioma CellsCancersMay 16, 2021Kim S, Heo S, Brzostowski J, Kang D.in the figure legends: Rapamycin were obtained from Invivogen, Hong Kong; recombinant rat PDGF–BB (520-BB-050) was purchased from R&D Systems, Minneapolis, MN, USA; chlorpromazine was purchased from Sigma-Aldrich,

(9) Improved Recovery from Liver Fibrosis by CrenolanibCellsApril 4, 2021Reichert D, Adolph L, Köhler JP, Buschmann T, Luedde T, Häussinger D, Kordes C.

(10) Ketogenic Diet Enhances the Cholesterol Accumulation in Liver and Augments the Severity of CCl₄ and TAA-Induced Liver Fibrosis in MiceInternational journal of molecular sciencesMarch 13, 2021Liao YJ, Wang YH, Wu CY, Hsu FY, Chien CY, Lee YC.

(11) PDGF Receptor Alpha Signaling Is Key for Müller Cell Homeostasis FunctionsInternational journal of molecular sciencesJanuary 25, 2021Díaz-Lezama N, Wolf A, Koch S, Pfaller AM, Biber J, Guillonneau X, Langmann T, Grosche A.

(12) BRD2 regulation of sigma-2 receptor upon cholesterol deprivationLife Science AllianceJanuary 1, 2021Hongtao Shen, Jing Li, Xiujie Xie, Huan Yang, Mengxue Zhang, Bowen Wang, K Craig Kent, Jorge Plutzky, Lian-Wang GuoPDGF-AA, 20 ng/ml; PDGF-BB, 20 ng/ml; TGFβ1, 20 ng/ml. PDGF-AA (Cat. no. 1055AA050), and PDGF-BB (Cat. no. 520BB050) were from R&D Systems. Human recombinant TGFβ1 was from Thermo Fisher Scientific (Cat. no. PHG9214).

(13) Periprocedural Hydrogen Sulfide Therapy Improves Vascular Remodeling and Attenuates Vein Graft DiseaseJournal of the American Heart AssociationNovember 17, 2020Kip P, Tao M, Trocha KM, MacArthur MR, Peters HAB, Mitchell SJ, Mann CG, Sluiter TJ, Jung J, Patterson S, et al.serum-free DMEM with/ without 10 ng/mL platelet-derived growth factor-BB (PDGF-BB, R&D Systems, cat# 520-BB-050). After J Am Heart Assoc. 2020;9:e016391. DOI: 10.1161/JAHA.120.0163915 Kip et al 6 hours incubation,

(14) Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alphaScientific reportsNovember 9, 2020Kadrmas JL, Beckerle MC, Yoshigi M.

(15) Gsta4 controls apoptosis of differentiating adult oligodendrocytes during homeostasis and remyelination via the mitochondria-associated Fas-Casp8-Bid-axisNature communicationsAugust 13, 2020Carlström KE, Zhu K, Ewing E, Krabbendam IE, Harris RA, Falcão AM, Jagodic M, Castelo-Branco G, Piehl F.

(16) Long-Term Exposure to Low-Dose Di-(2-ethylhexyl) Phthalate Impairs Cholesterol Metabolism in Hepatic Stellate Cells and Exacerbates Liver LibrosisInternational journal of environmental research and public healthMay 27, 2020Lee CY, Suk FM, Twu YC, Liao YJ.

(17) Heat shock protein 90 inhibitor AUY922 attenuates platelet-derived growth factor-BB-induced migration and proliferation of vascular smooth muscle cellsThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of PharmacologyMay 1, 2020Kim J, Lee KP, Kim BS, Lee SJ, Moon BS, Baek S.

(18) Reducing Th2 inflammation through neutralizing IL-4 antibody rescues myelination in IUGR rat brainJournal of neurodevelopmental disordersDecember 16, 2019Zanno AE, Romer MA, Fox L, Golden T, Jaeckle-Santos L, Simmons RA, Grinspan JB.

(19) Yes-Associated Protein 1 Plays Major Roles in Pancreatic Stellate Cell Activation and Fibroinflammatory ResponsesFrontiers in PhysiologyDecember 3, 2019Cheng Hu, Jiayue Yang, Hsin-Yuan Su, Richard T. Waldron, Mengmeng Zhi, Ling Li, Qing Xia, Stephen J. Pandol, Aurelia Lugeaagainst PDGFR-β (#sc-432) from Santa Cruz Biotechnology (Dallas, TX). Recombinant rat PDGF-BB (PDGF; #520-BB-050), recombinant mouse TGFβ1 (#7666-MB-005), and recombinant human TGFβ1 (#240-B-002) were from R&D Systems, Inc

(20) Growth Factor Signaling Regulates Mechanical Nociception in Flies and VertebratesThe Journal of neuroscience : the official journal of the Society for NeuroscienceJuly 24, 2019Lopez-Bellido R, Puig S, Huang PJ, Tsai CR, Turner HN, Galko MJ, Gutstein HB.

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PDGF-BB Protein

PDGF-BB Protein

PDGF-BB Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (50)

Reviews

PDGF-BB Protein from R&D Systems, a Bio-Techne Brand

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