Recombinant Human Osteopontin (OPN) Protein 1433-OP-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Osteopontin (OPN) Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $297.00Supplier Page View Company Product Page
Catalog Number1433-OP-050
Size50 ug
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
ApplicationsBioactivity
Conjugate/TagUnconjugated
SpeciesHuman
Molecule NameOsteopontin/OPN
Molecular WeightObserved: 60-65 kDa, reducing conditions
Theoretical: 32.9 kDa
Source/Expression SystemNS0-derived Recombinant Human Osteopontin (OPN) Protein
NCBI Full Gene Namesecreted phosphoprotein 1
NCBI Gene AliasesBSPI, OPN, ETA-1, BNSP
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Add to Compare List

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Spatial transcriptomics reveals altered communities and drivers of aberrant epithelia and pro-fibrotic fibroblasts in interstitial lung diseasesCell GenomicsMarch 11, 2026Alok Jaiswal, Tristan Kooistra, Vladislav Pokatayev, Hélder N. Bastos, Rita F. Santos, Tresa R. Sarraf, Åsa Segerstolpe, Crystal Lin, Liat Amir-Zilberstein, Shaina Twardus, et al.Thermo Fisher Scientific, #100-11), and SPP1 (Recombinant Human Osteopontin (OPN) Protein; R&D Systems, #1433-OP-050). Subsequently, RNA isolation of organoids was performed after 7 days of stimulation. Domes containing

(2) Single-cell transcriptomic analyses provide insights into SPP1+ TAM-mediated immune suppression and CD8+ T cell dysfunction in lung cancerCancer Immunology, ImmunotherapySeptember 29, 2025Rahma Taher Almgrami, Tengyue Zhang, Qitai Zhao, Mingming You, Jinyan Liu, Yi Zhangdays. The cells were then treated with different conditions: untreated, 0.5 µg SPP1 (R&D Systems Cat. 1433-OP-050), 1 µg anti-SPP1 (R&D Systems Cat. AF1433-SP), and a combination of 1 µg anti-SPP1 with 0.5 µg SPP1. Flow cytometry analysis

(3) Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19Nature communicationsMarch 10, 2025Lee JTH, Barnett SN, Roberts K, Ashwin H, Milross L, Cho JW, Huseynov A, Woodhams B, Aivazidis A, Li T, et al.recombinant human osteopontin at varying concentrations (0 µg/mL, 0.5 µg/mL, 1 µg/mL) (rhOPN; R&D Systems, 1433-OP-050) for 24 hours in serum and supplement-free growth medium (EGM, Lonza, CC-3162). Following the incubation,

(4) Single-cell RNA sequencing reveals the CRTAC1(+) population actively contributes to the pathogenesis of spinal ligament degeneration by SPP1(+) macrophageAging cellDecember 1, 2024Tang Y, Zhuo D, Yu Y, Pu W, Ma Y, Zhang Y, Huang Y, Zhang Q, Tang K, Meng C, et al.ligament cells from patients with traumatic injury were incubated with 200 ng/mL recombinant SPP1 protein (1433‐OP‐050, R&D Systems, USA). Total RNA and protein were extracted after 24‐h and 48‐h incubation, respectively,

(5) An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastomaScience advancesMarch 1, 2024Yang F, Akhtar MN, Zhang D, El-Mayta R, Shin J, Dorsey JF, Zhang L, Xu X, Guo W, Bagley SJ, et al.

(6) The CEBPB(+) glioblastoma subcluster specifically drives the formation of M2 tumor-associated macrophages to promote malignancy growthTheranosticsJanuary 1, 2024Yang Y, Jin X, Xie Y, Ning C, Ai Y, Wei H, Xu X, Ge X, Yi T, Huang Q, et al.

(7) Increased expression of OPN contributes to idiopathic pulmonary fibrosis and indicates a poor prognosisJournal of translational medicineSeptember 19, 2023Ji J, Zheng S, Liu Y, Xie T, Zhu X, Nie Y, Shen Y, Han X.(no. HY-12289). Mouse and human recombinant OPN were purchased from R&D Systems (no. 441-OP-050, no. 1433-OP-050). Mouse biotin-OPN was synthesized by Medchemexpress. The LV-OPN-siRNA was synthesized by GENECHEM (Shanghai,

(8) A Dual Role of Osteopontin in Modifying B Cell ResponsesBiomedicinesJuly 12, 2023Chunder R, Schropp V, Marzin M, Amor S, Kuerten S.

(9) Osteopontin (OPN) alleviates the progression of osteoarthritis by promoting the anabolism of chondrocytesGenes & diseasesJuly 1, 2023Luo W, Lin Z, Yuan Y, Wu Z, Zhong W, Liu Q.

(10) Osteopontin Promotes Macrophage M1 Polarization by Activation of the JAK1/STAT1/HMGB1 Signaling Pathway in Nonalcoholic Fatty Liver DiseaseJournal of clinical and translational hepatologyApril 28, 2023Xu Z, Xi F, Deng X, Ni Y, Pu C, Wang D, Lou W, Zeng X, Su N, Chen C, et al.IFNγ (Cat#: 315-05) was purchased from PeproTech (Rocky Hill, NJ, USA). Recombinant human OPN (Cat#: 1433-OP-050) was purchased from R&D Systems (Minneappolis, MN, USA). Identification of differentially expressed

(11) EMT-activated secretory and endocytic vesicular trafficking programs underlie a vulnerability to PI4K2A antagonism in lung cancerThe Journal of clinical investigationApril 3, 2023Tan X, Xiao GY, Wang S, Shi L, Zhao Y, Liu X, Yu J, Russell WK, Creighton CJ, Kurie JM.Active Motif; recombinant SPP1 proteins (ab92964) from Abcam; recombinant Gas6 (885-GSB) and SPP1 (1433-OP-050) proteins from R&D Systems; PI-273 (HY-103489) from MedChemExpress; NC03 (AOB17420) from Aobious; and

(12) Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritisArthritis research & therapyFebruary 17, 2023Umemoto A, Kuwada T, Murata K, Shiokawa M, Ota S, Murotani Y, Itamoto A, Nishitani K, Yoshitomi H, Fujii T, et al.

(13) Differential Modulation of Human M1 and M2 Macrophage Activity by ICOS-Mediated ICOSL TriggeringInternational journal of molecular sciencesFebruary 2, 2023Gigliotti CL, Dianzani C, Stoppa I, Monge C, Sutti S, Sblattero D, Puricelli C, Rolla R, Dianzani U, Boggio E.

(14) Osteopontin Exacerbates High-Fat Diet-Induced Metabolic Disorders in a Microbiome-Dependent MannermBioDecember 20, 2022Chen J, Zeng P, Gong L, Zhang X, Ling Z, Bi K, Shi F, Wang K, Zhang Q, Jiang J, et al.

(15) Paper-based aptasensor for colorimetric detection of osteopontinAnalytica chimica actaMarch 15, 2022Pereira AC, Moreira FTC, Rodrigues LR, Sales MGF.

(16) General anaesthetics reduce acute lymphoblastic leukaemia malignancies in vitro and in vivovia CXCR4 and osteopontin mediated mechanismsF1000ResearchJanuary 1, 2022Jiang C, Gonzalez-Anton S, Li X, Mi E, Wu L, Zhao H, Zhang G, Lu A, Lo Celso C, Ma D.

(17) Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damageNature communicationsNovember 18, 2021Martín-Alonso M, Iqbal S, Vornewald PM, Lindholm HT, Damen MJ, Martínez F, Hoel S, Díez-Sánchez A, Altelaar M, Katajisto P, et al.

(18) Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8The Journal of biological chemistryNovember 1, 2021Santamaria S, Martin DR, Dong X, Yamamoto K, Apte SS, Ahnström J.

(19) Lipid-injured hepatocytes release sOPN to improve macrophage migration via CD44 engagement and pFak-NFκB signalingCytokineJune 1, 2021Jiang X, Zhang F, Ji X, Dong F, Yu H, Xue M, Qiu Y, Yang F, Hu X, Bao Z.

(20) Integrin αvβ3 Engagement Regulates Glucose Metabolism and Migration through Focal Adhesion Kinase (FAK) and Protein Arginine Methyltransferase 5 (PRMT5) in Glioblastoma CellsCancers (Basel)March 5, 2021Pulin Che, Lei Yu, Gregory K. Friedman, Meimei Wang, Xiaoxue Ke, Huafeng Wang, Wenbin Zhang, Burt Nabors, Qiang Ding, Xiaosi HanUSA) and PF-562271 (Selleckchem, Houston, TX, USA), Osteopontin (R&D System, Minneapolis, MN, USA, #1433-OP-050), 2-NBDG (Thermo Fisher Scientific, Waltham, MA, USA), Lactate Assay kit (BioVision, Milpitas, CA, USA),

Be the First to Write a Review!

Osteopontin/OPN Protein

Osteopontin/OPN Protein

Osteopontin/OPN Protein

Osteopontin/OPN Protein

Osteopontin/OPN Protein

Recombinant Human Osteopontin (OPN) Protein from R&D Systems, a Bio-Techne Brand

Description

R&D Systems, a Bio-Techne Brand

Citations (53)

Reviews

Recombinant Human Osteopontin (OPN) Protein from R&D Systems, a Bio-Techne Brand

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map