Recombinant Human IL-10 Protein 217-IL-005 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human IL-10 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $364.00Supplier Page View Company Product Page
Catalog Number217-IL-005
SpeciesHuman
Size5 ug (also 10 ug, 25 ug, 50 ug, 250 ug)
Molecule NameIL-10
NCBI Full Gene Nameinterleukin 10
NCBI Gene AliasesIL10A, TGIF, GVHDS, IL-10, CSIF
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular Weight18.6 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemSf 21 (baculovirus)-derived Recombinant Human IL-10 Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Testosterone and estradiol reduce inflammation of human macrophages induced by anti-SARS-CoV-2 IgGEuropean journal of immunologyDecember 1, 2024Allahverdiyeva S, Geyer CE, Veth J, de Vries LM, de Taeye SW, van Gils MJ, den Dunnen J, Chen HJ.

(2) A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesisCell death and differentiationAugust 1, 2024Cheng YC, Acedera JD, Li YJ, Shieh SY.been described previously [34]. The following recombinant proteins were used: IL1α (200-LA-002), IL10 (217-IL-005), CCL4 (271-BME-010), CCL20 (360-MP-025), FGF7 (251-KG-010), and IL15 (247-ILB-005) from R&D Systems,

(3) An ImmunoFET Coupled with an Immunomagnetic Preconcentration Technique for the Sensitive EIS Detection of HF BiomarkersMicromachines (Basel)February 21, 2024Hamdi Ben Halima, Nadia Zine, Imad Abrao Nemeir, Norman Pfeiffer, Albert Heuberger, Joan Bausells, Abdelhamid Elaissari, Nicole Jaffrezic-Renault, Abdelhamid Errachid250. BioTechne (R&D Systems, Noyal-Châtillon-sur-Seiche, France) supplied recombinant human IL-10 (217-IL-005), human monoclonal anti-IL-10 antibody (MAB217-SP), human polyclonal anti-IL-10 antibody (AF-217-SP),

(4) The role of extracellular vesicle fusion with target cells in triggering systemic inflammationNature communicationsFebruary 7, 2024Papareddy P, Tapken I, Kroh K, Varma Bhongir RK, Rahman M, Baumgarten M, Cim EI, Györffy L, Smeds E, Neumann A, et al.

(5) Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colonCell stem cellNovember 2, 2023Múnera JO, Kechele DO, Bouffi C, Qu N, Jing R, Maity P, Enriquez JR, Han L, Campbell I, Mahe MM, et al.Systems,236-EGF-01M recombinant human FGF4,R&D Systems,235-F4 recombinant human IL-10,R&D Systems,217-IL-005 recombinant human NOGGIN,R&D Systems,6057-NG TransIT-LT1 Transfection Reagent,Mirus Bio,MIR2300 TrypLE

(6) TIM-3 Expression and M2 Polarization of Macrophages in the TGFβ-Activated Tumor Microenvironment in Colorectal CancerCancersOctober 11, 2023Katagata M, Okayama H, Nakajima S, Saito K, Sato T, Sakuma M, Fukai S, Endo E, Sakamoto W, Saito M, et al.

(7) Blocking autofluorescence in brain tissues affected by ischemic stroke, hemorrhagic stroke, or traumatic brain injuryFrontiers in ImmunologyMay 29, 2023Shaoshuai Wang, Xiuhua Ren, Junmin Wang, Qinfeng Peng, Xiaoyu Niu, Chunhua Song, Changsheng Li, Chao Jiang, Weidong Zang, Marietta Zille, et al.transient cerebral ischemia for 90 minutes. Injection of IL-10 conjugated to Cy5.5 Briefly, 25 µg IL-10 (R&D Systems, 217-IL-005) and the fluorescent dye Cy5.5 (Med Chem Express, HY-D0924) were incubated overnight, and the unbound

(8) Pathogenic Interleukin-10 Receptor Alpha Variants in Humans — Balancing Natural Selection and Clinical ImplicationsJournal of Clinical ImmunologyFebruary 1, 2023Dominik Aschenbrenner, Ziqing Ye, Ying Zhou, Wenhui Hu, Isabel Brooks, Isabelle Williams, Melania Capitani, Lisa Gartner, Daniel Kotlarz, Scott B. Snapper, et al.penicillin, and streptomycin. Stimulations with recombinant human cytokines (IL-10 (R&D Systems; Cat 217-IL-005), IL-6 (Peprotech; Cat 200–06), Universal type I interferon (pbl assay science; Cat 11,200–1)) were

(9) PD-1(high)CXCR5(-)CD4(+) peripheral helper T cells promote CXCR3(+) plasmablasts in human acute viral infectionCell reportsJanuary 31, 2023Asashima H, Mohanty S, Comi M, Ruff WE, Hoehn KB, Wong P, Klein J, Lucas C, Cohen I, Coffey S, et al.

(10) Role of circular RNA cdr1as in modulation of macrophage phenotypeLife sciencesNovember 15, 2022Gonzalez C, Cimini M, Cheng Z, Benedict C, Wang C, Trungcao M, Mallaredy V, Rajan S, Garikipati VNS, Kishore R.anti-inflammatory activation [20], 10 ng/mL IL-4 (R&D systems Cat# 404-ML-010), 10 ng/mL IL-10 (R&D systems Cat# 217-IL-005), and 20 ng/mL TGF-β (R&D systems Cat#7666-MB-005) for a period of 24 h (Fig. 1A). 2.3. RNA isolation Total

(11) Kdm6a suppresses the alternative activation of macrophages and impairs energy expenditure in obesityCell death and differentiationMay 1, 2021Chen J, Xu X, Li Y, Li F, Zhang J, Xu Q, Chen W, Wei Y, Wang X.

(12) Tissue-specific endothelial cell heterogeneity contributes to unequal inflammatory responsesScientific reportsJanuary 21, 2021Gunawardana H, Romero T, Yao N, Heidt S, Mulder A, Elashoff DA, Valenzuela NM.

(13) JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortalityScience advancesJanuary 1, 2021Stebbing J, Sánchez Nievas G, Falcone M, Youhanna S, Richardson P, Ottaviani S, Shen JX, Sommerauer C, Tiseo G, Ghiadoni L, et al.

(14) Pomalidomide restores immune recognition of primary effusion lymphoma through upregulation of ICAM-1 and B7-2PLoS pathogensJanuary 1, 2021Shrestha P, Davis DA, Jaeger HK, Stream A, Aisabor AI, Yarchoan R.

(15) Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 HoursTransplantationSeptember 1, 2020Haug V, Kollar B, Tasigiorgos S, Endo Y, Kauke M, Safi AF, Veeramani A, Abdulrazzak O, Bausk B, Walt D, et al.antibody Supplier Catalog # Supplier Catalog # Supplier Catalog # GMCSF R&D Systems 215GM-010 R&D Systems MAB615 R&D Systems BAF215 IFN-g R&D Systems 285-IF100 BioLegend 507502 R&D Systems MAB285 IL-1beta R&D systems 201-LB005 Biolegend 508202 BioLegend 511703 IL-6 R&D 206-IL010 R&D Systems MAB206 R&D Systems BAF206 IL-8 R&D 208-IL010 BD Bioscience 554716 BD Bioscience 554718 TNFalpha R&D systems 210-TA R&D systems MAB610 Abcam ab9635 IL12p70 R&D Systems 219-IL005 BioLegend 511001 BioLegend 508801 IL-17A BioLegend 570509 R&D Systems MAB317 R&D Systems BAF317 IL-15 R&D Systems MAB647 R&D Systems 247-IL005 R&D Systems BAM247 IL-10 R&D Systems 217-IL005 BioLegend 506801 BioLegend 501501 IL-2 R&D Systems 202-IL010 R&D Systems MAB602 R&D Systems MAB202 IL-7 R&D systems 207-IL005 BioLegend 501302 BioLegend 506601 Figure

(16) Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES)Biomedical journalJune 1, 2020Hsieh MY, Lin JJ, Hsia SH, Huang JL, Yeh KW, Chang KW, Lee WI.

(17) Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomesNature communicationsMay 25, 2020Abasıyanık MF, Wolfe K, Van Phan H, Lin J, Laxman B, White SR, Verhoef PA, Mutlu GM, Patel B, Tay S.

(18) IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory NetworkJournal of immunology (Baltimore, Md. : 1950)April 15, 2020Sun L, Girnary M, Wang L, Jiao Y, Zeng E, Mercer K, Zhang J, Marchesan JT, Yu N, Moss K, et al.

(19) Anti-inflammatory cytokines IL-35 and IL-10 block atherogenic lysophosphatidylcholine-induced, mitochondrial ROS-mediated innate immune activation, but spare innate immune memory signature in endothelial cellsRedox biologyJanuary 1, 2020Li X, Fang P, Sun Y, Shao Y, Yang WY, Jiang X, Wang H, Yang X.human IL-35 (#ALX-522-140-C010) was purchased from Enzo (Farmingdale, NY). Recombinant human IL-10 (#217-IL-005) and TGF-β (#240-B-002) were purchased from R&D systems (Minneapolis, MN). For mtROS measurement, MitoSOX

(20) Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polypsMucosal immunologyJanuary 1, 2020Ogasawara N, Poposki JA, Klingler AI, Tan BK, Hulse KE, Stevens WW, Peters AT, Grammer LC, Welch KC, Smith SS, et al.

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IL-10 Protein

IL-10 Protein

IL-10 Protein

IL-10 Protein

Recombinant Human IL-10 Protein from R&D Systems, a Bio-Techne Brand

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R&D Systems, a Bio-Techne Brand

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Recombinant Human IL-10 Protein from R&D Systems, a Bio-Techne Brand

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