Recombinant Human Fc gamma RI/CD64 Protein, CF 1257-FC-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Fc gamma RI/CD64 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $465.00Supplier Page View Company Product Page
Catalog Number1257-FC-050
SpeciesHuman
Size50 ug
FormatLyophilized from a 0.2 µm filtered solution in PBS
Molecule NameFc gamma RI/CD64
NCBI Full Gene NameFc gamma receptor Ia, Fc gamma receptor Ib, pseudogene
NCBI Gene AliasesFcgammaRIa, CD64, FcgammaRI, FCG1, IGFRB, CD34, FcRI, CD64A, CD64b, FCGR1B, IGFR1, FCRI, FCGR1
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 45-55 kDa, reducing conditions
Theoretical: 31.4 kDa
ApplicationsBinding Activity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human Fc gamma RI/CD64 Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Targeting BCMA in multiple myeloma with a trifunctional NK cell engagerCell Reports MedicineMarch 17, 2026Alexandre Tang, Laurent Gauthier, Elisa Zaghi, Jochen Beninga, Céline Amara, Alexandra Basset, Benjamin Rossi, Dorothée Bourges, Céline Nicolazzi, Pauline Rettman, et al.al.17https://doi.org/10.1016/j.cell.2019.04.041 His-tagged Human FcgRI (CD64); GenBank P12314,R&D Systems,1257-FC-050 His-tagged human NKp46; GenBank NM_004829.5,Innate Pharma,Gauthier et al.17https://doi.org/10.1016/j.cell.2019.04.041 M2-tagged

(2) ESAT-6 and CFP-10 reactive IgG in patients with tuberculosis inhibits intracellular bacteriaCell ReportsDecember 23, 2025Joshua R. Miles, Pei Lu, Shuangyi Bai, Genesis P. Aguillón-Durán, Javier E. Rodríguez-Herrera, Bronwyn M. Gunn, Blanca I. Restrepo, Lenette L. Lu,R&D Systems,Cat#1875-CD Recombinant FcRn,R&D Systems,Cat#8639-FC-050 Recombinant FcγRI/CD64,R&D Systems,Cat#1257-FC-050 PE/R-Phycoerythrin Conjugation Kit,Abcam,Cat# ab102918 EZ-Link™ Sulfo-NHS-LC-Biotin,Thermo Scientific,Cat#21335 Streptavidin Magnetic Beads

(3) Heterologous Ad26/Ad5 adenovirus-vectored vaccines elicited SARS-CoV-2-specific antibody responses with potent Fc activitiesFrontiers in ImmunologyMay 8, 2024Jéromine Klingler, Shreyas Kowdle, Juan C. Bandres, Rozita Emami-Gorizi, Raymond A. Alvarez, Priyanka G. Rao, Fatima Amanat, Charles Gleason, Giulio Kleiner, Viviana Simon, et al.spike-Ab or RBD-Ab complexes were incubated with His-tagged recombinant FcγRI/CD64 (R&D Systems™, #1257FC050), FcγRIIa/CD32a (R&D Systems™, #1330CD050/CF) or FcγRIIIa/CD16a (R&D Systems™, #4325FC050) proteins

(4) Repurposing Fc gamma receptor I (FcγRI, CD64) for site-oriented monoclonal antibody capture: A proof-of-concept study for real-time detection of tumor necrosis factor-alpha (TNF -α)HeliyonSeptember 1, 2023Çapkın E, Kutlu A, Yüce M.

(5) Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivoScience advancesDecember 9, 2022Torchia JA, Tavares AH, Carstensen LS, Chen DY, Huang J, Xiao T, Mukherjee S, Reeves PM, Tu H, Sluder AE, et al.

(6) Fcγ receptor-mediated cross-linking codefines the immunostimulatory activity of anti-human CD96 antibodiesJCI insightOctober 10, 2022Rogel A, Ibrahim FM, Thirdborough SM, Renart-Depontieu F, Birts CN, Buchan SL, Preville X, King EV, Al-Shamkhani A.

(7) Combined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergyNature communicationsSeptember 27, 2022An SB, Yang BG, Jang G, Kim DY, Kim J, Oh SM, Oh N, Lee S, Moon JY, Kim JA, et al.

(8) Discovery of a novel Igβ and FcγRIIB cross-linking antibody, ASP2713, and its potential application in the treatment of systemic lupus erythematosusInternational immunopharmacologyDecember 1, 2021Kitanaga Y, Yamajuku D, Kubo S, Nakamura K, Maeda M, Seki M, Kaneko Y, Kinugasa F, Morokata T, Kondo Y, et al.

(9) Human Monoclonal Antibodies against NS1 Protein Protect against Lethal West Nile Virus InfectionmBioOctober 26, 2021Wessel AW, Doyle MP, Engdahl TB, Rodriguez J, Crowe JE Jr, Diamond MS.

(10) Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malariaeLifeJune 29, 2021Aitken EH, Damelang T, Ortega-Pajares A, Alemu A, Hasang W, Dini S, Unger HW, Ome-Kaius M, Nielsen MA, Salanti A, et al.

(11) High neutralizing potency of swine glyco-humanized polyclonal antibodies against SARS-CoV-2European journal of immunologyJune 1, 2021Vanhove B, Duvaux O, Rousse J, Royer PJ, Evanno G, Ciron C, Lheriteau E, Vacher L, Gervois N, Oger R, et al.

(12) An IgG-based bispecific antibody for improved dual targeting in PSMA-positive cancerEMBO molecular medicineFebruary 5, 2021Zekri L, Vogt F, Osburg L, Müller S, Kauer J, Manz T, Pflügler M, Maurer A, Heitmann JS, Hagelstein I, et al.

(13) Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal modelsmAbsJanuary 1, 2021Kumar S, Ghosh S, Sharma G, Wang Z, Kehry MR, Marino MH, Neben TY, Lu S, Luo S, Roberts S, et al.performed on each antibody titration, and EC50 values were calculated. Binding of dostarlimab to FcγRI (Cat#1257-FC-050), FcγRIIa (Cat#9595-CD-050), FcγRIIb (Cat#1875-CD-050), FcγRIIIa (Cat#4325-FC-050), and FcγRIIIb (Cat#1597-FC-050;

(14) Immune-stimulating antibody conjugates elicit robust myeloid activation and durable anti-tumor immunityNature CancerJanuary 1, 2021Shelley E. Ackerman et al.Analysis His-tagged Fc Gamma Receptor (FCGR) proteins were obtained from R&D Systems (FCGR1 (CD64, cat# 1257-FC-050), FCGR2A (CD32a, cat# 1257-FC-050), FCGR2B (CD32b, cat# 1875-FC-050), FCGR3A (CD16a, cat# 4235-FC-050).

(15) Antibodies targeting epitopes on the cell-surface form of NS1 protect against Zika virus infection during pregnancyNature communicationsOctober 19, 2020Wessel AW, Kose N, Bombardi RG, Roy V, Chantima W, Mongkolsapaya J, Edeling MA, Nelson CA, Bosch I, Alter G, et al.

(16) High Potency of a Bivalent Human V(H) Domain in SARS-CoV-2 Animal ModelsCellOctober 15, 2020Li W, Schäfer A, Kulkarni SS, Liu X, Martinez DR, Chen C, Sun Z, Leist SR, Drelich A, Zhang L, et al.paper,N/A SARS2 RBD N501A,This paper,N/A SARS2 RBD Y505A,This paper,N/A Recombinant FcγRIA,R&D systems,Cat# 1257-FC-050 Recombinant FcγRIIA,R&D systems,Cat# 1330-CD-050 Recombinant FcγRIIIA,R&D systems,Cat# 4325-FC-050 ,, Critical

(17) Urinary cMet as a prognostic marker in immunoglobulin A nephropathyJournal of cellular and molecular medicineOctober 1, 2020An JN, Li L, Lee J, Yu SS, Kim JH, Lee J, Kim YC, Kim DK, Oh YK, Lim CS, et al.

(18) Pharmacologic Characterization of ALD403, a Potent Neutralizing Humanized Monoclonal Antibody Against the Calcitonin Gene-Related PeptideJournal of Pharmacology and Experimental TherapeuticsJuly 1, 2020Leon F. Garcia-Martinez et al.a 30 ml/min for 300 seconds’ flow. Prior to immobilization, the Fcg receptors [FcgRI/CD64, cat. no. 1257-FC-050; FcgRIIA/CD32a, cat. no. 1330CD-050; FcgRIIB/C (CD32b/c), cat. no. 1875-CD-050; FcgRIIIA/ CD16a, cat.

(19) Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor BindingStructureMay 1, 2020Chiara Orlandi, Daniel Deredge, Krishanu Ray, Neelakshi Gohain, William Tolbert, Anthony L. DeVico, Patrick Wintrode, Marzena Pazgier, George K. LewisSynagis (Palivizumab),Medimmune,60574-4114-1 Human Recombinant FcγR receptor I/CD64,R&D systems,Cat# 1257-FC-050 Human Recombinant FcγR receptor IIA/CD32a,R&D systems,Cat# 1330-CD-050 Human Recombinant FcγR receptor

(20) Insertion of N-Terminal Hinge Glycosylation Enhances Interactions of the Fc Region of Human IgG1 Monomers with Glycan-Dependent Receptors and Blocks Hemagglutination by the Influenza VirusJournal of immunology (Baltimore, Md. : 1950)March 1, 2019Blundell PA, Lu D, Wilkinson M, Dell A, Haslam S, Pleass RJ.

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Fc gamma RI/CD64 Protein

Fc gamma RI/CD64 Protein

Fc gamma RI/CD64 Protein

Recombinant Human Fc gamma RI/CD64 Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human Fc gamma RI/CD64 Protein, CF from R&D Systems, a Bio-Techne Brand

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