Recombinant Mouse TWEAK/TNFSF12 Protein 1237-TW-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Mouse TWEAK/TNFSF12 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $449.00Supplier Page View Company Product Page
Catalog Number1237-TW-025
SpeciesMouse
Size25 ug
Source/Expression SystemE. coli-derived Recombinant Mouse TWEAK/TNFSF12 Protein
Molecule NameTWEAK/TNFSF12
NCBI Full Gene Nametumor necrosis factor (ligand) superfamily, member 12
NCBI Gene AliasesTweak, Apo3l, Dr3l, Dr3lg
FormatLyophilized from a 0.2 µm filtered solution in PBS and NaCl with BSA as a carrier protein
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular Weight17 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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(1) Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid nicheNature communicationsMay 10, 2023Haensel D, Daniel B, Gaddam S, Pan C, Fabo T, Bjelajac J, Jussila AR, Gonzalez F, Li NY, Chen Y, et al.

(2) EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexiaNatureMay 1, 2023Bilgic SN, Domaniku A, Toledo B, Agca S, Weber BZC, Arabaci DH, Ozornek Z, Lause P, Thissen JP, Loumaye A, et al.

(3) NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular carcinoma progression via JAK2/STAT5 inhibitionMolecular metabolismDecember 1, 2022Vesting AJ, Jais A, Klemm P, Steuernagel L, Wienand P, Fog-Tonnesen M, Hvid H, Schumacher AL, Kukat C, Nolte H, et al.

(5) TRAF2 Cooperates with Focal Adhesion Signaling to Regulate Cancer Cell Susceptibility to AnoikisMolecular cancer therapeuticsJanuary 1, 2019da Silva SD, Xu B, Maschietto M, Marchi FA, Alkailani MI, Bijian K, Xiao D, Alaoui-Jamali MA.

(6) TWEAK/Fn14 mediates atrial-derived HL-1 myocytes hypertrophy via JAK2/STAT3 signalling pathwayJournal of cellular and molecular medicineSeptember 1, 2018Hao L, Ren M, Rong B, Xie F, Lin MJ, Zhao YC, Yue X, Han WQ, Zhong JQ.

(7) Fn14 deficiency ameliorates psoriasis-like skin disease in a murine modelCell death & diseaseJuly 23, 2018Peng L, Li Q, Wang H, Wu J, Li C, Liu Y, Liu J, Xia L, Xia Y.

(8) NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosusNature communicationsJanuary 12, 2018Brightbill HD, Suto E, Blaquiere N, Ramamoorthi N, Sujatha-Bhaskar S, Gogol EB, Castanedo GM, Jackson BT, Kwon YC, Haller S, et al.

(9) TWEAK blockade decreases atherosclerotic lesion size and progression through suppression of STAT1 signaling in diabetic miceScientific reportsApril 27, 2017Fernández-Laso V, Sastre C, Méndez-Barbero N, Egido J, Martín-Ventura JL, Gómez-Guerrero C, Blanco-Colio LM.

(10) TWEAK/Fn14 system and crescent formation in IgA nephropathyBMC nephrologyMarch 14, 2015Sasaki Y, Shimizu Y, Suzuki Y, Horikoshi S, Tomino Y.

(11) Nrf2 protects against TWEAK-mediated skeletal muscle wastingScientific reportsJanuary 10, 2014Al-Sawaf O, Fragoulis A, Rosen C, Kan YW, Sönmez TT, Pufe T, Wruck CJ.

(12) Regulation of innate CD8+ T-cell activation mediated by cytokinesProceedings of the National Academy of Sciences of the United States of AmericaJune 19, 2012Freeman BE, Hammarlund E, Raué HP, Slifka MK.

(13) TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvantBiochemical and biophysical research communicationsJuly 3, 2009Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Yoshida T, Yamashita K, Yoshikawa T, Hiroi T, Itoh N, Kawai Y, et al.

(14) TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokineFASEB journal : official publication of the Federation of American Societies for Experimental BiologyJune 1, 2007Dogra C, Changotra H, Wedhas N, Qin X, Wergedal JE, Kumar A.

(15) TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cellsArthritis research & therapyJanuary 1, 2006Ando T, Ichikawa J, Wako M, Hatsushika K, Watanabe Y, Sakuma M, Tasaka K, Ogawa H, Hamada Y, Yagita H, et al.

Recombinant Mouse TWEAK/TNFSF12 Protein from R&D Systems, a Bio-Techne Brand