Caspase-4 Inhibitor Z-YVAD-FMK FMK005 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemCaspase-4 Inhibitor Z-YVAD-FMK
CompanyR&D Systems, a Bio-Techne Brand
Price $319.00Supplier Page View Company Product Page
Catalog NumberFMK005
Size1 mg
TypePeptides
SpeciesMulti-Species
StorageStore the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date
NCBI Full Gene Namecaspase 4
NCBI Gene AliasesICE(rel)II, ICEREL-II, ICH-2, Mih1, Mih1/TX, TX

Specifications/Features

Available conjugates: Sizes Available: 1 mg

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Tumour initiated purinergic signalling promotes cardiomyocyte RBFOX1 degradation and cardiotoxicity from DNA damaging anticancer agentsNat CommunJuly 25, 2025Saymon Tejay, Maria Areli Lorenzana-Carrillo, Guocheng Huang, Seyed Amirhossein Tabatabaei Dakhili, Yuan -Yuan Zhao, Farah Eaton, Michelle Mendiola Pla, Dawn E. Bowles, Adam Kinnaird, D. Ian Paterson, et al.(sigma-aldrich PZ0337) was given at 10 uM unless otherwise stated. Pan-caspase inhibitor (Biotechne FMK005) was given at 50 uM and Caspase 1 inhibitor (EMD Millipore 400011) was given at 10 uM. Chemotherapeutics

(2) Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasionNat CommunMay 25, 2025Victoria Roulstone, Joan Kyula-Currie, James Wright, Emmanuel C. Patin, Isaac Dean, Lu Yu, Aida Barreiro-Alonso, Miriam Melake, Jyoti Choudhary, Richard Elliott, et al.therapy to observe rescue from cells treated without inhibitors. The caspase-4 inhibitor (Z-YVAD-FMK, FMK005, R&D systems) was used in further experiments at the dose of 50 µM. Cell survival was measured by MTT assay

(3) Constitutive secretion of pro-IL-18 allows keratinocytes to initiate inflammation during bacterial infectionPLoS pathogensApril 1, 2023Johnson AF, Sands JS, Trivedi KM, Russell R, LaRock DL, LaRock CN.

(4) Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosisScientific reportsJuly 1, 2022Kobayashi T, Mitsuhashi A, Hongying P, Shioya M, Kojima K, Nishikimi K, Yahiro K, Shozu M.

(5) Clustering of Tir during enteropathogenic E. coli infection triggers calcium influx-dependent pyroptosis in intestinal epithelial cellsPLoS biologyDecember 1, 2020Zhong Q, Roumeliotis TI, Kozik Z, Cepeda-Molero M, Fernández LÁ, Shenoy AR, Bakal C, Frankel G, Choudhary JS.

(6) The Pseudomonas aeruginosa protease LasB directly activates IL-1βEBioMedicineOctober 1, 2020Sun J, LaRock DL, Skowronski EA, Kimmey JM, Olson J, Jiang Z, O'Donoghue AJ, Nizet V, LaRock CN.(201-LB; R&D Systems), 5 μM caspase inhibitors zVAD-fmk, YVAD-fmk, DEVD-fmk, and IETD-fmk (FMK001, FMK005, FMK004, FMK007; R&D Systems), 10 μg/mL complete protease inhibitor cocktail (11697498001; Roche), 1x

(7) Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer's DiseaseCell reportsJune 30, 2020Park G, Nhan HS, Tyan SH, Kawakatsu Y, Zhang C, Navarro M, Koo EH.pan-caspase inhibitor, R&D Systems), 10 μM zDEVD (FMK004, caspase-3 inhibitor, R&D Systems), 10 μM zYVAD (FMK005, caspase-4 inhibitor, R&D Systems), 10 μM zVEID (FMK006, caspase-6 inhibitor, R&D Systems), and 10 μM

(8) PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathwayCell death & diseaseFebruary 15, 2019Baek JH, Yun HS, Kwon GT, Lee J, Kim JY, Jo Y, Cho JM, Lee CW, Song JY, Ahn J, et al.

(9) Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1β productionCell death & diseaseFebruary 7, 2018Tang AC, Rahavi SM, Fung SY, Lu HY, Yang H, Lim CJ, Reid GS, Turvey SE.

(10) Corticosterone Preexposure Increases NF-κB Translocation and Sensitizes IL-1β Responses in BV2 Microglia-Like CellsFrontiers in immunologyJanuary 1, 2018Liu J, Mustafa S, Barratt DT, Hutchinson MR.dependency of LPS-induced IL-1β responses was tested using putative inhibitor z-YVAD-FMK (R&D Systems, FMK005, USA), which was co-incubated with LPS treatment at concentrations between 100 nM and 10 µM. A 5 µM

(11) Production and regulation of interleukin-1 family cytokines at the materno-fetal interfaceCytokineNovember 1, 2017Scott LM, Bryant AH, Rees A, Down B, Jones RH, Thornton CA.

(12) Processing and secretion of guanylate binding protein-1 depend on inflammatory caspase activityJournal of cellular and molecular medicineSeptember 1, 2017Naschberger E, Geißdörfer W, Bogdan C, Tripal P, Kremmer E, Stürzl M, Britzen-Laurent N.

(13) NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytesThe Journal of experimental medicineMay 1, 2017Freeman L, Guo H, David CN, Brickey WJ, Jha S, Ting JP.stimulation and were maintained in cell culture during LPC stimulation. The caspase-1 inhibitor YVAD (FMK005) was purchased from R&D Systems. NAC (A9165) and MPG (M6635) were purchased from Sigma-Aldrich. APDC

(14) Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size SpecificFrontiers in immunologyJanuary 1, 2017Nishijima N, Hirai T, Misato K, Aoyama M, Kuroda E, Ishii KJ, Higashisaka K, Yoshioka Y, Tsutsumi Y.

(15) Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell deathNature communicationsNovember 3, 2016Thurston TL, Matthews SA, Jennings E, Alix E, Shao F, Shenoy AR, Birrell MA, Holden DW.

(16) IL-1β is an innate immune sensor of microbial proteolysisScience immunologyAugust 1, 2016LaRock CN, Todd J, LaRock DL, Olson J, O'Donoghue AJ, Robertson AA, Cooper MA, Hoffman HM, Nizet V.

(17) Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial PneumoniaPLoS pathogensDecember 1, 2015González-Juarbe N, Gilley RP, Hinojosa CA, Bradley KM, Kamei A, Gao G, Dube PH, Bergman MA, Orihuela CJ.

(18) Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus InfectionThe Journal of biological chemistryJuly 10, 2015Callaway JB, Smith SA, McKinnon KP, de Silva AM, Crowe JE Jr, Ting JP.

(19) BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER StressMolecular therapy : the journal of the American Society of Gene TherapyMay 1, 2015Roulstone V, Pedersen M, Kyula J, Mansfield D, Khan AA, McEntee G, Wilkinson M, Karapanagiotou E, Coffey M, Marais R, et al.

(20) A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injuryEMBO molecular medicineApril 1, 2015Whidbey C, Vornhagen J, Gendrin C, Boldenow E, Samson JM, Doering K, Ngo L, Ezekwe EA Jr, Gundlach JH, Elovitz MA, et al.

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Caspase-4 Inhibitor Z-YVAD-FMK from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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Caspase-4 Inhibitor Z-YVAD-FMK from R&D Systems, a Bio-Techne Brand

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