Dkk-1 Protein 5439-DK-010/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemDkk-1 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $429.00Supplier Page View Company Product Page
Catalog Number5439-DK-010/CF
SpeciesHuman
FormatLyophilized from a 0.2 µm filtered solution in PBS
Molecule NameDkk-1
Source/Expression SystemSf 21 (baculovirus)-derived Recombinant Human Dkk-1 Protein, CF
Size10 ug (also 100 ug, 1 mg)
NCBI Full Gene Namedickkopf WNT signaling pathway inhibitor 1
NCBI Gene AliasesSK, DKK-1
Purity>95%, by SDS-PAGE with silver staining
Conjugate/TagUnconjugated
ApplicationsBioactivity
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 10 ug (also 100 ug, 1 mg)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cellsFront ImmunolFebruary 6, 2025Angela Armento, Inga Sonntag, Ana-Cristina Almansa-Garcia, Merve Sen, Sylvia Bolz, Blanca Arango-Gonzalez, Ellen Kilger, Ruchi Sharma, Kapil Bharti, Rosario Fernandez-Godino, et al.NO636-100G, Sigma-Aldrich), Noggin 50ng/ml (day 0-4, 1967-NG-025/CF, R&D systems), DKK-1 10 ng/ml (day 0-6, 5439-DK-010/CF, R&D Systems), IGF-1 10ng/ml (day 0-6, 1291-G1-200, R&D Systems), bFGF 5 ng/ml (day 2-4, AF-100-18B,

(2) Identification of ligand-receptor pairs that drive human astrocyte developmentNature neuroscienceAugust 1, 2023Voss AJ, Lanjewar SN, Sampson MM, King A, Hill EJ, Sing A, Sojka C, Bhatia TN, Spangle JM, Sloan SA.(Sino Biological, Cat. 16135-H08H, 100 ng/uL), DKK1 (Sigma-Aldrich, Cat. SRP3258–10UG, R&D Systems, Cat. 5439-DK-010/CF, 100 ng/uL), and BMP4 (Sigma-Aldrich, Cat. H4916–10UG, R&D Systems, Cat. 314-BP-010/CF, 20 ng/uL). RNA-Sequencing

(3) Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathwayJournal of cell scienceMarch 15, 2023Rickman M, Ghim M, Pang K, von Huelsen Rocha AC, Drudi EM, Sureda-Vives M, Ayoub N, Tajadura-Ortega V, George SJ, Weinberg PD, et al.

(4) Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer's Disease Brains and Mouse Neurodegeneration ModelseNeuroJanuary 1, 2023Aghaizu ND, Jolly S, Samra SK, Kalmar B, Craessaerts K, Greensmith L, Salinas PC, De Strooper B, Whiting PJ.performed at 21 DIV for 24 h: human DKK2 (Bio-Techne, 6628-DK-010/CF, 100 ng/ml), human DKK1 (Bio-Techne, 5439-DK-010/CF, 100 ng/ml), human WNT7a (Bio-Techne, 3008-WN-010/CF, 200 ng/ml); 100 ng/ml bovine serum albumin (BSA)

(5) Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune ResponsesVirusesDecember 29, 2022Feige L, Kozaki T, Dias de Melo G, Guillemot V, Larrous F, Ginhoux F, Bourhy H.

(6) R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeletoneLifeNovember 2, 2022Nagano K, Yamana K, Saito H, Kiviranta R, Pedroni AC, Raval D, Niehrs C, Gori F, Baron R.

(7) Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular DegenerationCellsNovember 2, 2022Ng ESY, Kady N, Hu J, Dave A, Jiang Z, Pei J, Gorin MB, Matynia A, Radu RA.

(8) miR-181-5p attenuates neutrophilic inflammation in asthma by targeting DEKInternational immunopharmacologyNovember 1, 2022Song Y, Wang Z, Jiang J, Piao Y, Bai Q, Piao Q, Li L, Xu C, Liu H, Piao H, et al.

(9) Non-canonical Wnt signaling participates in Jagged1-induced osteo/odontogenic differentiation in human dental pulp stem cellsScientific reportsMay 9, 2022Kornsuthisopon C, Chansaenroj A, Manokawinchoke J, Tompkins KA, Pirarat N, Osathanon T.

(10) Actions of CSF2 and DKK1 on bovine embryo development and pregnancy outcomes are affected by composition of embryo culture mediumScientific reportsMay 7, 2022Amaral TF, de Grazia JGV, Martinhao LAG, De Col F, Siqueira LGB, Viana JHM, Hansen PJ.

(11) Dickkopf-1 Promotes Angiogenesis and is a Biomarker for Hepatic Stem Cell-like Hepatocellular CarcinomaInternational journal of molecular sciencesMarch 3, 2022Suda T, Yamashita T, Sunagozaka H, Okada H, Nio K, Sakai Y, Yamashita T, Mizukoshi E, Honda M, Kaneko S.

(12) Epithelial plasticity in COPD results in cellular unjamming due to an increase in polymerized actinJournal of cell scienceFebruary 15, 2022Ghosh B, Nishida K, Chandrala L, Mahmud S, Thapa S, Swaby C, Chen S, Khosla AA, Katz J, Sidhaye VK.

(13) Effects of baicalin on the proliferation and expression of OPG and RANKL in human cementoblast-lineage cellsJournal of dental sciencesJanuary 1, 2022Kunimatsu R, Kimura A, Sakata S, Tsuka Y, Yoshimi Y, Abe T, Kado I, Yashima Y, Izumino J, Nakatani A, et al.

(14) Combination of Wnt/β-Catenin Targets S100A4 and DKK1 Improves Prognosis of Human Colorectal CancerCancersDecember 22, 2021Dahlmann M, Monks A, Harris ED, Kobelt D, Osterland M, Khaireddine F, Herrmann P, Kemmner W, Burock S, Walther W, et al.

(15) Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domainScience advancesNovember 12, 2021Kowalski-Jahn M, Schihada H, Turku A, Huber T, Sakmar TP, Schulte G.645-WN-010), WNT-surrogate-Fc fusion protein [U-Protein Express B.V., N001; (57)], and DKK1 (R&D Systems, 5439-DK-010/CF). The lyophilized preparations of recombinant WNTs and DKK1 were dissolved in 0.1% bovine serum albumin

(16) Transcriptome-Wide Analysis Reveals a Role for Extracellular Matrix and Integrin Receptor Genes in Otic Neurosensory Differentiation from Human iPSCsInternational journal of molecular sciencesOctober 7, 2021Johnson Chacko L, Lahlou H, Steinacher C, Assou S, Messat Y, Dudás J, Edge A, Crespo B, Crosier M, Sergi C, et al.

(17) Topological isolation of developmental regulators in mammalian genomesNature communicationsAugust 12, 2021Wu HJ, Landshammer A, Stamenova EK, Bolondi A, Kretzmer H, Meissner A, Michor F.treatment, differentiation media was supplemented with 150 ng/ml recombinant human DKK1 (R&D Systems, 5439-DK-010/CF). DKK4 enzyme-linked immunosorbent assay (ELISA) Cell culture media supernatants from undifferentiated

(18) Overexpressed sFRP3 exerts an inhibitory effect on hepatocellular carcinoma via inactivation of the Wnt/β-catenin signaling pathwayCancer gene therapyAugust 1, 2021Fang L, Gao C, Bai RX, Wang HF, Du SY.

(19) Wnt/β-catenin signaling mediates the abnormal osteogenic and adipogenic capabilities of bone marrow mesenchymal stem cells from chronic graft-versus-host disease patientsCell death & diseaseMarch 23, 2021Qi HZ, Ye YL, Suo Y, Qu H, Zhang HY, Yang KB, Fan ZP, Huang F, Xuan L, Chen YQ, et al.

(20) Ubiquitin-specific protease 53 promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cellsCell death & diseaseMarch 4, 2021Baek D, Park KH, Lee KM, Jung S, Joung S, Kim J, Lee JW.