Recombinant Human IL-17A Protein, CF 317-ILB-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human IL-17A Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $421.00Supplier Page View Company Product Page
Catalog Number317-ILB-050
SpeciesHuman
FormatLyophilized from a 0.2 µm filtered solution in HCl
Molecule NameIL-17/IL-17A
Size50 ug (also 200 ug)
Source/Expression SystemE. coli-derived Recombinant Human IL-17A Protein, CF
NCBI Full Gene Nameinterleukin 17A
NCBI Gene AliasesIL-17A, ILA17, CTLA-8, CTLA8, IL17, IL-17
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular Weight16 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Immunopeptidome analysis reveals SERPINB3 as an autoantigen driving eczematized psoriasisSci AdvOctober 24, 2025Manja Jargosch, Jomy Kuruvila, Emanuele Scala, Johannes Grosch, Jessica Eigemann, Sophia Wasserer, Shalva Lekiashvili, Nico Trautwein, Daniel Johannes Kowalewski, Alexander Böhner, et al.5 hours in DermaLife Basal Medium following stimulation with human recombinant IL-17A (R&D Systems, 317-ILB-050, 50 ng/ml), TNF [R&D Systems, 210_TA-005, 10 (when in combination) or 50 ng/ml (single stimulation)],

(2) IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo via eicosanoid signallingeBioMedicineOctober 1, 2025Shreya Ghimire, Biyun Xue, Kun Li, Ryan M. Gannon, Christine L. Wohlford-Lenane, Andrew L. Thurman, Huiyu Gong, Grace C. Necker, Jian Zheng, David K. Meyerholz, et al.IL-17 (R&D Systems, 210-TA) combined with 10 ng/mL tumour necrosis factor alpha (TNFα, R&D Systems, 317-ILB-050) for 4 or 55 days. The cytokines were applied to both apical and basolateral side of HAE. The cells

(3) Targeting fibroblast TNF receptor 1 attenuates type 17 skin inflammationCell reportsAugust 26, 2025Cavagnero KJ, Li F, Aguilera C, Jo H, Palomo-Irigoyen M, Mares AR, Chan H, Gallo RL.

(4) IL-17 triggers PD-L1 gene transcription in NSCLC cells via TRIM31-dependent MEF2C K63-linked polyubiquitinationBMC CancerJanuary 14, 2025Shuai Ying, Ningxia Wu, Yuting Ruan, Wen Ge, Pei Ma, Tongpeng Xu, Yongqian Shu, Yingwei Wang, Wen Qiu, Chenhui Zhaowere obtained from Biosharp Biotech (Hefei, China). Recombinant human IL-17 A (called IL-17, Cat. no. 317-ILB-050) was obtained from R&D Systems (Minneapolis, MN, USA). Lipofectamine 2000 (Cat. no. 11668019) was purchased

(5) The intersection of inflammation and DNA damage as a novel axis underlying the pathogenesis of autism spectrum disordersbioRxiv : the preprint server for biologyDecember 11, 2024Jhanji M, Krall CL, Guevara A, Yoon B, Sajish M, Boccuto L, Lizarraga SB.

(6) Neutrophils in nasal polyps exhibit transcriptional adaptation and proinflammatory roles that depend on local polyp milieuJCI insightNovember 22, 2024Zhang C, Zhang Q, Chen J, Li H, Cheng F, Wang Y, Gao Y, Zhou Y, Shi L, Yang Y, et al.HNECs and fibroblasts were stimulated with OSM (10 ng/mL; 8475-OM, R&D Systems), IL-17A (10 ng/mL; 317-ILB-050, R&D Systems), or IL-13 (10 ng/mL; 213-ILB-010, R&D Systems) for 12 or 24 hours. Cultured cells and

(7) The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosisPloS oneJanuary 1, 2024Caratis F, Opiełka M, Hausmann M, Velasco-Estevez M, Rojek B, de Vallière C, Seuwen K, Rogler G, Karaszewski B, Rutkowska A.overnight with a cocktail of 10 ng/ml TNFα (R&D Systems, 210-TA-100/CF) and 50 ng/ml IL-17A (R&D Systems, 317-ILB-050) recombinant cytokines. After treatments, MO3.13 cells were washed in PBS and scraped in 200 μl of Fenozol

(8) Exogenous DNA enhances DUOX2 expression and function in human pancreatic cancer cells by activating the cGAS-STING signaling pathwayFree Radical Biology and MedicineAugust 1, 2023Stephen L. Wang, Yongzhong Wu, Mariam Konaté, Jiamo Lu, David Mallick, Smitha Antony, Jennifer L. Meitzler, Guojian Jiang, Iris Dahan, Agnes Juhasz, et al.was obtained from MedChem Express. Recombinant human cytokines Human IL-4 (204-IL-050), Human IL-17A (317-ILB-050), Human IFN-α (11100-1) and Human IFN-β (8499-IF-010) were from R & D Systems. 2’-3’ cGAMP (tlrl-nacga23-5)

(9) Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasisNature communicationsJune 12, 2023Ma F, Plazyo O, Billi AC, Tsoi LC, Xing X, Wasikowski R, Gharaee-Kermani M, Hile G, Jiang Y, Harms PW, et al.stimulation, RNA extraction, qRT-PCR Control and KO keratinocytes were stimulated with IL-17A (R&D Systems # 317-ILB-050, concentration used—20 ng/ml), TNF (R&D Systems # 210-TA-020, concentration used—10 ng/ml) for 24 h.

(10) JAK Signaling Is Critically Important in Cytokine-Induced Viral Susceptibility of KeratinocytesInternational journal of molecular sciencesMay 25, 2023Arnold KA, Peterson LF, Beck LA, Brewer MG.

(11) IL-17/CXCL5 signaling within the oligovascular niche mediates human and mouse white matter injuryCell reportsDecember 20, 2022Xiao G, Kumar R, Komuro Y, Burguet J, Kakarla V, Azizkhanian I, Sheth SA, Williams CK, Zhang XR, Macknicki M, et al.

(12) IL-17RA-signaling in Lgr5(+) intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitmentImmunityFebruary 8, 2022Lin X, Gaudino SJ, Jang KK, Bahadur T, Singh A, Banerjee A, Beaupre M, Chu T, Wong HT, Kim CK, et al.L34957 Recombinant mouse IL-17A,R&D Systems,Cat#: 421-ML/CF Recombinant human IL-17A,R&D Systems,Cat#: 317-ILB-050 Recombinant mouse IL-25,R&D Systems,Cat#: 1399-IL/CF Recombinant mouse IL-22,R&D Systems,Cat#: 582-ML SsoAdvanced™

(13) Interplay Between Chemotherapy-Activated Cancer Associated Fibroblasts and Cancer Initiating Cells Expressing CD44v6 Promotes Colon Cancer ResistanceFrontiers in oncologyJanuary 1, 2022Ghatak S, Hascall VC, Karamanos N, Markwald RR, Misra S.

(14) Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilarisJCI insightOctober 22, 2021Shao S, Chen J, Swindell WR, Tsoi LC, Xing X, Ma F, Uppala R, Sarkar MK, Plazyo O, Billi AC, et al.Sigma-Aldrich), IFN-γ (10 ng/mL, 285-IF, R&D Systems), TNF (10 ng/mL, 210-TA-020, R&D Systems), IL-17A (10 ng/mL, 317-ILB-050, R&D Systems), TNF plus IL-17A, prostaglandin E2 (10 μM, P0409, Sigma-Aldrich), PC (10 μM, HY-B2233B,

(15) MicroRNA-378a-3p is overexpressed in psoriasis and modulates cell cycle arrest in keratinocytes via targeting BMP2 geneScientific reportsJuly 9, 2021Soonthornchai W, Tangtanatakul P, Meesilpavikkai K, Dalm V, Kueanjinda P, Wongpiyabovorn J.

(16) Biomarkers for Comorbidities Modulate the Activity of T-Cells in COPDInternational journal of molecular sciencesJuly 2, 2021Jamal Jameel K, Gallert WJ, Yanik SD, Panek S, Kronsbein J, Jungck D, Koch A, Knobloch J.CX3CL1, (all from R&D Systems, Wiesbaden, Germany; cat# 3548-F2, 236E6, 394-PA, B003-5, 336-MD/8F, 317-ILB-050, 365-FR/CF) and BNP (Biomol GmbH, Hamburg, Germany, cat# 87386). After 72 h, the culture supernatants

(17) Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regenerationTheranosticsJanuary 1, 2021Ebner-Peking P, Krisch L, Wolf M, Hochmann S, Hoog A, Vári B, Muigg K, Poupardin R, Scharler C, Schmidhuber S, et al.serum-free medium for 2 hours before stimulation with 100 ng/ml recombinant human Interleukin 17A (317-ILB-050, R&D Systems) dissolved in 4 mM HCL. For the human Phospho-RTK Kit and the human NFkB Pathway Array

(18) The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunityScientific reportsOctober 15, 2020Gorchs L, Ahmed S, Mayer C, Knauf A, Fernández Moro C, Svensson M, Heuchel R, Rangelova E, Bergman P, Kaipe H.

(19) T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal InflammationCell reportsJune 30, 2020Yan J, Pandey SP, Barnes BJ, Turner JR, Abraham C.

(20) Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21AgingApril 17, 2020Mercurio L, Lulli D, Mascia F, Dellambra E, Scarponi C, Morelli M, Valente C, Carbone ML, Pallotta S, Girolomoni G, et al.

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Recombinant Human IL-17A Protein, CF

IL-17/IL-17A Protein

IL-17/IL-17A Protein

Recombinant Human IL-17A Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human IL-17A Protein, CF from R&D Systems, a Bio-Techne Brand

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