IL-34 Protein 5265-IL-010 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-34 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $408.00Supplier Page View Company Product Page
Catalog Number5265-IL-010
SpeciesHuman
Size10 ug
Molecule NameIL-34
NCBI Full Gene Nameinterleukin 34
NCBI Gene AliasesIL-34, C16orf77
FormatLyophilized from a 0.2 µm filtered solution in PBS and NaCl with BSA as a carrier protein
Purity>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 33-41 kDa, reducing conditions
Theoretical: 26.1 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human IL-34 Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 10 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Human brain cell types shape host-rabies virus transcriptional interactions revealing a preexisting pro-viral astrocyte subpopulationCell ReportsSeptember 23, 2025Lena Feige, Karl Young, Juan Pablo Cerapio, Tatsuya Kozaki, Lauriane Kergoat, Valentina Libri, Florent Ginhoux, Milena Hasan, Lamya Ben Ben Ameur, Gregory Chin, et al.supplemented with 50 ng/mL recombinant human CSF-1 (216-MC-010, R&D Systems) and 50 ng/mL human IL-34 (5265-IL-010, R&D Systems). Cells were co-cultured for three consecutive weeks before infection experiments were

(2) CD33-CD45 Interaction Reveals a Mechanistic Link to Alzheimer's Disease SusceptibilitybioRxiv : the preprint server for biologyJuly 31, 2025Vo N, Rillahan CD, Chatila ZK, Virga DM, Hall JL, Tamucci KA, Rashid M, Connor SM, Chintamen S, Guzman G, et al.

(3) Reduced SH3RF3 may protect against Alzheimer's disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signalingbioRxiv : the preprint server for biologyFebruary 13, 2025Patel R, Cheng R, Cardona CL, Angeles E, Singh G, Miller S, Ashok A, Teich AF, Piriz A, Maldonado A, et al.

(4) Parkinson's disease-derived α-synuclein assemblies combined with chronic-type inflammatory cues promote a neurotoxic microglial phenotypeJournal of neuroinflammationFebruary 21, 2024Yildirim-Balatan C, Fenyi A, Besnault P, Gomez L, Sepulveda-Diaz JE, Michel PP, Melki R, Hunot S.

(5) Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microgliaJournal of neuroinflammationFebruary 13, 2024Sung W, Noh MY, Nahm M, Kim YS, Ki CS, Kim YE, Kim HJ, Kim SH.

(6) slan+ Monocytes Kill Cancer Cells Coated in Therapeutic Antibody by TrogoptosisCancer immunology researchNovember 1, 2023Finotti G, Pietronigro E, Balanzin C, Lonardi S, Constantin G, Chao MP, Tecchio C, Vermi W, Cassatella MA.

(7) Angiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya diseaseScientific reportsSeptember 8, 2023Shirozu N, Ohgidani M, Hata N, Tanaka S, Inamine S, Sagata N, Kimura T, Inoue I, Arimura K, Nakamizo A, et al.

(8) Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD micebioRxiv : the preprint server for biologyAugust 25, 2023Pan AL, Audrain M, Sakakibara E, Joshi R, Zhu X, Wang Q, Wang M, Beckmann ND, Schadt EE, Gandy S, et al.

(9) Mitochondria dysregulation contributes to secondary neurodegeneration progression post-contusion injury in human 3D in vitro triculture brain tissue modelCell death & diseaseAugust 3, 2023Liaudanskaya V, Fiore NJ, Zhang Y, Milton Y, Kelly MF, Coe M, Barreiro A, Rose VK, Shapiro MR, Mullis AS, et al.(TGFβ) growth factors. Then 1 ml of fresh media was supplemented with IL-34 (R&D systems, cat. No. 5265-IL-010), MCSF (Invitrogen, cat.no. PHC9501), and TGFβ (Fisher, cat.no. 5018578) growth factors every other

(10) Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune ResponsesVirusesDecember 29, 2022Feige L, Kozaki T, Dias de Melo G, Guillemot V, Larrous F, Ginhoux F, Bourhy H.co-culture, 50 ng/mL recombinant human CSF-1 (216-MC-010, R & D Systems) and 50 ng/mL human IL-34 (5265-IL-010, R & D Systems) were added every third day to the culture medium. 2.6. Transfer of Conditioned Medium Cell

(11) Cladribine Treatment for MS Preserves the Differentiative Capacity of Subsequently Generated Monocytes, Whereas Its Administration In Vitro Acutely Influences Monocyte Differentiation but Not Microglial ActivationFrontiers in immunologyJanuary 1, 2022Medeiros-Furquim T, Ayoub S, Johnson LJ, Aprico A, Nwoke E, Binder MD, Kilpatrick TJ.resuspended in 0.5 mL of microglia medium supplemented with 40 ng/mL of the CSF1R ligand IL-34 (R&D SYSTEMS, #5265-IL-010), and counted using a hemocytometer. Trypan blue staining (Gibco, #15250061) was used for discrimination

(12) Microglial transcription profiles in mouse and human are driven by APOE4 and sexiScienceNovember 19, 2021Moser VA, Workman MJ, Hurwitz SJ, Lipman RM, Pike CJ, Svendsen CN.supplemented with 2mM GlutaMAX (#35050061, Gibco), 10 ng/ml GM-CSF, and 100 ng/ml interleukin -34 (IL-34; #5265-IL-010, R&D Systems). Half-media changes were performed every other day for 2 weeks, before cells were treated

(13) Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanismsNeuronAugust 4, 2021Shi Y, Andhey PS, Ising C, Wang K, Snipes LL, Boyer K, Lawson S, Yamada K, Qin W, Manis M, et al.

(14) Interleukin-34-CSF1R Signaling Axis Promotes Epithelial Cell Transformation and Breast TumorigenesisInternational journal of molecular sciencesMarch 8, 2021Poudel M, Kim G, Bhattarai PY, Kim JY, Choi HS.

(15) Validation of Induced Microglia-Like Cells (iMG Cells) for Future Studies of Brain DiseasesFrontiers in cellular neuroscienceJanuary 1, 2021Banerjee A, Lu Y, Do K, Mize T, Wu X, Chen X, Chen J.

(16) Protocol for Tri-culture of hiPSC-Derived Neurons, Astrocytes, and MicrogliaSTAR protocolsDecember 18, 2020Ryan SK, Jordan-Sciutto KL, Anderson SA.Recombinant human/murine/rat BDNF,Peprotech,450-02 Recombinant human EGF,R&D Systems,236-EG-200 Recombinant human IL-34,R&D Systems,5265-IL-010 Recombinant human NT-3,Peprotech,450-03 Recombinant human TGF-β1,Peprotech,100-21 RPMI 1640,Corning,10-041-CV RPMI

(17) Over-Expression of Allograft Inflammatory Factor-1 (AIF-1) in Patients with Rheumatoid ArthritisBiomoleculesJuly 16, 2020Piotrowska K, Słuczanowska-Głabowska S, Kurzawski M, Dziedziejko V, Kopytko P, Paczkowska E, Rogińska D, Safranow K, Machaliński B, Pawlik A.

(18) Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV InfectionStem cell reportsApril 14, 2020Ryan SK, Gonzalez MV, Garifallou JP, Bennett FC, Williams KS, Sotuyo NP, Mironets E, Cook K, Hakonarson H, Anderson SA, et al.SH30027.01) with 10% FBS (HyClone, SH30071.03HI), recombinant human IL-34 (100 ng/mL, R&D Systems, 5265-IL-010), CSF-1 recombinant human protein (25 ng/mL, Thermo Fisher Scientific, PHC9504), and recombinant human

(19) Autocrine Production of Interleukin-34 Promotes the Development of Endometriosis through CSF1R/JAK3/STAT6 signalingScientific reportsNovember 14, 2019Lin K, Ma J, Peng Y, Sun M, Xu K, Wu R, Lin J.

(20) Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruningNature neuroscienceMarch 1, 2019Sellgren CM, Gracias J, Watmuff B, Biag JD, Thanos JM, Whittredge PB, Fu T, Worringer K, Brown HE, Wang J, et al.Fisher Scientific) with 1% penicillin-streptomycin, 0.1 μg ml−1 of IL-34 (R&D Systems, catalog no. 5265-IL-010) and 0.01 μg ml−1 of granulocyte-macrophage colony-stimulating factor (R&D Systems, catalog no. 215-GM-010/CF).

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IL-34 Protein

IL-34 Protein

IL-34 Protein

IL-34 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (28)

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IL-34 Protein from R&D Systems, a Bio-Techne Brand

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