Recombinant Human Gremlin Protein, CF 5190-GR-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Gremlin Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $416.00Supplier Page View Company Product Page
Catalog Number5190-GR-050
Size50 ug
ApplicationsBioactivity
FormatLyophilized from a 0.2 µm filtered solution in PBS and EDTA
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 25-30 kDa, under reducing conditions
Theoretical: 19.7 kDa
Conjugate/TagUnconjugated
SpeciesHuman
Molecule NameGremlin
Source/Expression SystemNS0-derived Recombinant Human Gremlin Protein, CF
NCBI Full Gene Namegremlin 1, DAN family BMP antagonist
NCBI Gene AliasesGREMLIN, DUP15q, DAND2, CKTSF1B1, HMPS1, CRAC1, IHG-2, DRM, MPSH, PIG2, HMPS, C15DUPq, CRCS4
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Angiogenic and Fibrogenic Dual-effect of Gremlin1 on Proliferative Diabetic RetinopathyInternational journal of biological sciencesJanuary 1, 2024Wu X, Qin B, Cheng R, Zhou R, Wang X, Zhang Z, Mao X, Xie Z, Chen M, Jiang L, et al.of ECM containing 0.5% FBS with or without 200 ng/ mL recombinant Gremlin1 protein (R&D Systems, Cat#5190-GR-050) or 100 μM Fasudil (MCE, Cat# HY-10341A). Then the cells were added to the upper chamber. After incubation

(2) Unveiling the transcriptomic landscape and the potential antagonist feedback mechanisms of TGF-β superfamily signaling module in bone and osteoporosisCell communication and signaling : CCSNovember 28, 2022Wang YW, Lin WY, Wu FJ, Luo CW.from Sigma-Aldrich. Human BMP2 (355-BM), human TGF-β1 (240-B), human NOG (6057-NG-025), human GREM1 (5190-GR-050) and human GREM2 (8436-PR-050) proteins were purchased from R&D systems. Recombinant human BMP8A protein

(3) αVβ8 integrin targeting to prevent posterior capsular opacificationJCI insightNovember 8, 2021Shihan MH, Novo SG, Wang Y, Sheppard D, Atakilit A, Arnold TD, Rossi NM, Faranda AP, Duncan MK.

(4) Targeting Gremlin 1 Prevents Intestinal Fibrosis Progression by Inhibiting the Fatty Acid Oxidation of Fibroblast CellsFrontiers in pharmacologyJanuary 1, 2021Yang Y, Zeng QS, Zou M, Zeng J, Nie J, Chen D, Gan HT.37°C in a 5% CO2 atmosphere. Exogenous GREM1, used for cell treatment, purchased from R&D system (cat#:5190-GR-050). STR identification was conducted to exclude exogenic cell contamination. Cell Proliferation Assays Enumeration

(5) Gremlin-1 Promotes Metastasis of Breast Cancer Cells by Activating STAT3-MMP13 Signaling PathwayInternational journal of molecular sciencesDecember 3, 2020Sung NJ, Kim NH, Surh YJ, Park SA.

(6) Gremlin-1 augments the oestrogen-related receptor α signalling through EGFR activation: implications for the progression of breast cancerBritish journal of cancerSeptember 1, 2020Park SA, Sung NJ, Choi BJ, Kim W, Kim SH, Surh YJ.

(7) ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and diseaseCellular signallingApril 1, 2020Schivo S, Khurana S, Govindaraj K, Scholma J, Kerkhofs J, Zhong L, Huang X, van de Pol J, Langerak R, van Wijnen AJ, et al.

(8) DHA inhibits Gremlin-1-induced epithelial-to-mesenchymal transition via ERK suppression in human breast cancer cellsBioscience reportsMarch 27, 2020Sung NJ, Kim NH, Bae NY, Jo HS, Park SA.

(9) Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variantOncogeneJanuary 1, 2020Veschi V, Mangiapane LR, Nicotra A, Di Franco S, Scavo E, Apuzzo T, Sardina DS, Fiori M, Benfante A, Colorito ML, et al.

(10) No evidence of Gremlin1-mediated activation of VEGFR2 signaling in endothelial cellsThe Journal of biological chemistryNovember 29, 2019Dutton LR, O'Neill CL, Medina RJ, Brazil DP.

(11) Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progressionBreast cancer research : BCRSeptember 18, 2019Ren J, Smid M, Iaria J, Salvatori DCF, van Dam H, Zhu HJ, Martens JWM, Ten Dijke P.

(12) Organoid culture media formulated with growth factors of defined cellular activityScientific reportsApril 17, 2019Urbischek M, Rannikmae H, Foets T, Ravn K, Hyvönen M, de la Roche M.factors used in the study are: R-spondin 1 (amino acids 31–263; cat. 4645-RS-025), Gremlin 1 (cat. 5190-GR-050), FGF-2 (cat. 233-FB-010), Neuregulin-1/NRG-1 (cat. 396-HB/CF) and EGF (cat. 236-EG-200), all from R&D Systems

(13) YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular developmenteLifeFebruary 5, 2018Neto F, Klaus-Bergmann A, Ong YT, Alt S, Vion AC, Szymborska A, Carvalho JR, Hollfinger I, Bartels-Klein E, Franco CA, et al.

(14) Generation and Applications of a DNA Aptamer against Gremlin-1Molecules (Basel, Switzerland)April 28, 2017Li Q, Huo Y, Guo Y, Zheng X, Sun W, Hao Z.

(15) Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programmeNature communicationsJanuary 20, 2017Li A, Figueroa S, Jiang TX, Wu P, Widelitz R, Nie Q, Chuong CM.

(16) BMP signalling in human fetal ovary somatic cells is modulated in a gene-specific fashion by GREM1 and GREM2Molecular Human ReproductionSeptember 6, 2016Rosemary A. Bayne, Douglas J. Donnachie, Hazel L. Kinnell, Andrew J. Childs, Richard A. Andersonμg/ml,1–100 ng/ml as indicated in text "Recombinant Human Gremlin, CF","R&D Systems (Abingdon, UK)",5190-GR-050,PBS,200 μg/ml,1 μg/ml "Recombinant Human PRDC/GREM2, CF","R&D Systems (Abingdon, UK)",8436-PR-050,4

(17) Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-β (TGF-β) signaling promoting SMAD3 activation and fibrosis via Gremlin proteinThe Journal of biological chemistryApril 4, 2014O'Reilly S, Ciechomska M, Cant R, van Laar JM.

(18) Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglinBlood cancer journalMarch 21, 2014Olsen OE, Wader KF, Misund K, Våtsveen TK, Rø TB, Mylin AK, Turesson I, Størdal BF, Moen SH, Standal T, et al.

(19) Quantitative kinetics analysis of BMP2 uptake into cells and its modulation by BMP antagonistsJournal of cell scienceJanuary 1, 2013Alborzinia H, Schmidt-Glenewinkel H, Ilkavets I, Breitkopf-Heinlein K, Cheng X, Hortschansky P, Dooley S, Wölfl S.

(20) Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitorsNatureJuly 26, 2012Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, et al.

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Recombinant Human Gremlin Protein, CF

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Recombinant Human Gremlin Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human Gremlin Protein, CF from R&D Systems, a Bio-Techne Brand

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