Recombinant Human Integrin alpha V beta 8 Protein, CF 4135-AV-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Integrin alpha V beta 8 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $528.00Supplier Page View Company Product Page
Catalog Number4135-AV-050
Size50 ug
ApplicationsBinding Activity
FormatLyophilized from a 0.2 µm filtered solution in Tris, NaCl and MgCl2
Molecular WeightObserved: 130-155 kDa and 85-100 kDa, reducing conditions
Theoretical: 110.5 kDa ( alpha V subunit), 75.3 kDa (ÃŸ8 subunit)
Conjugate/TagUnconjugated
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
SpeciesHuman
Molecule NameIntegrin alpha V beta 8
Source/Expression SystemCHO-derived Recombinant Human Integrin alpha V beta 8 Protein, CF
NCBI Full Gene Nameintegrin subunit beta 8, integrin subunit alpha V, aldehyde dehydrogenase 9 family member A1
NCBI Gene AliasesCD51, ALDH9, VNRA, ALDH4, ALDH7, VTNR, E3, TMABADH, MSK8, TMABA-DH, TMABALDH
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 2 weeks, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Add to Compare List

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Overcoming Immune Checkpoint Inhibitor Resistance with Potent, Selective Dual αvβ6/8 Inhibitors Based on Engineered Lasso PeptidesJournal of the American Chemical SocietySeptember 10, 2025Lechner A, Jordan PA, Machado da Cruz GC, Lamson J, Gordon J, Okada BK, Anderson K, Chaudhari R, Rosario CJ, Mikesell J, et al.

(2) The RGD-binding integrins αvβ6 and αvβ8 are receptors for mouse adenovirus-1 and -3 infectionPLoS pathogensDecember 1, 2021Bieri M, Hendrickx R, Bauer M, Yu B, Jetzer T, Dreier B, Mittl PRE, Sobek J, Plückthun A, Greber UF, et al.(7889-AV-050/3050-AV-050), αvβ5 (7706-AV-050/2528-AV-050), αvβ6 (7480-AV-050/3817-AV-050), αvβ8 (8314-AV-050/4135-AV-050), recombinantly expressed in and secreted from CHO cells (quality control shown in S8 Fig). Human αvβ6

(3) Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across speciesCellSeptember 16, 2021Tabebordbar M, Lagerborg KA, Stanton A, King EM, Ye S, Tellez L, Krunnfusz A, Tavakoli S, Widrick JJ, Messemer KA, et al.6579-AVB-050), ɑVβ3 (R&D Systems, 3050-AV-050), ɑVβ6 (R&D Systems, 3817-AV-050), ɑVβ8 (R&D Systems, 4135-AV-050), or maltose-binding protein (Novus Biologicals, NBC1–18538) at 37°C for 30 minutes. Virus and protein

(4) Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapyCell reportsJuly 6, 2021Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, et al.background to permit post-natal survival were immunized with recombinant αvβ8 integrin (R&D Systems, 4135-AV-050) 50 μg per mouse every two weeks. Sera from immunized mice were screened by solid phase immunoassays

(5) LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltrationNatureOctober 1, 2018Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, He L, Chen Y, Chen H, Luo W, et al.(CT039-H2508H, Sino Biological Inc), mintegrin-α5β6 (CT051-M2508H, Sino Biological Inc), integrin-α5β8 (4135-AV-050, R&D systems), integrin-α6β4 (5497-A6–050, R&D systems), integrin-α8β1 (CT016-H2508H, Sino Biological Inc

(6) Pharmacologic Blockade ofαvβ1 Integrin Ameliorates Renal Failure and FibrosisIn VivoJournal of the American Society of NephrologyJuly 1, 2017Yongen Chang, Wei Ling Lau, Hyunil Jo, Kazuyuki Tsujino, Leslie Gewin, Nilgun Isik Reed, Amha Atakilit, Ane Claudia Fernandes Nunes, William F. DeGrado, Dean Sheppardavb8 antibody Adwa11 was generated by injecting Itgb82/2 mice with recombinant human avb8 protein (Cat#4135-AV-050; R&D Systems). The speciﬁcity of Adwa11 to avb8 was tested on 293T cells stably expressing human avb8

(7) Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T CellsMolecular therapy : the journal of the American Society of Gene TherapyJanuary 4, 2017Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A, Costa-Guerra JA, Violette S, et al.plates were coated with recombinant αvβ6 (3817-AV-050), αvβ3 (3050-AV-050), αvβ5 (2528-AV-050), αvβ8 (4135-AV-050) integrin proteins (all R&D systems) in PBS overnight. Wells were washed with PBS supplemented with

(8) The TGF-β inhibitory activity of antibody 37E1B5 depends on its H-CDR2 glycanmAbsJanuary 1, 2017Tsui P, Higazi DR, Wu Y, Dunmore R, Solier E, Kasali T, Bond NJ, Huntington C, Carruthers A, Hood J, et al.

(9) Oxidation-induced structural changes of ceruloplasmin foster NGR motif deamidation that promotes integrin binding and signalingThe Journal of biological chemistryFebruary 7, 2014Barbariga M, Curnis F, Spitaleri A, Andolfo A, Zucchelli C, Lazzaro M, Magnani G, Musco G, Corti A, Alessio M.

(10) Critical role of flanking residues in NGR-to-isoDGR transition and CD13/integrin receptor switchingThe Journal of biological chemistryMarch 19, 2010Curnis F, Cattaneo A, Longhi R, Sacchi A, Gasparri AM, Pastorino F, Di Matteo P, Traversari C, Bachi A, Ponzoni M, et al.

Be the First to Write a Review!

Integrin alpha V beta 8 Protein

Integrin alpha V beta 8 Protein

Recombinant Human Integrin alpha V beta 8 Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

Citations (10)

Reviews

Recombinant Human Integrin alpha V beta 8 Protein, CF from R&D Systems, a Bio-Techne Brand

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map