Boc-QAR-AMC Fluorogenic Peptide Substrate ES014 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemBoc-QAR-AMC Fluorogenic Peptide Substrate
CompanyR&D Systems, a Bio-Techne Brand
Price $337.00Supplier Page View Company Product Page
Catalog NumberES014
Size10 mg
SpeciesMulti-Species
Molecule NameProtease Substrates
StorageSamples are stable for up to twelve months from date of receipt at -20° C to -70° C. The substrate can be aliquoted and stored -20° C to -70° C in a manual defrost freezer for three months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light
Source/Expression SystemSynthetic

Specifications/Features

Available conjugates: Sizes Available: 10 mg

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infectionEmerging Microbes & InfectionsDecember 31, 2026Lianne Presley, Jimena Pérez-Vargas, Anaïs Saintigny, Iván Villanueva, Michelle Ho, Jessica Fone, Lara Brinsden, Nidhi Kaushik, Syan Olver, Connor A. H. Thompson, et al.Boc-Gln-Ala-Arg-7-amino-4-methylcoumarine (Boc-QAR-AMC) fluorogenic peptide substrate was purchased from R&D Systems (#ES014). The 1 nM TMPRSS2 was incubated with serially diluted compounds (0.098 nM to 50 nM) for 30 min at room

(2) From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 VariantsJournal of Medicinal ChemistryApril 10, 2025Gabriel Lemieux, Jimena Pérez-Vargas, Antoine Désilets, Malihe Hassanzadeh, Connor A. H. Thompson, Alice Gravel-Trudeau, Alexandre Joushomme, Siobhan Ennis, Ivan Villanueva, Étienne Marouseau, et al.chromatography as previously demonstrated by our group. Fluorogenic substrates Boc-QAR-AMC (Bio-Techne, ES014), Boc-RVRR-AMC (Bachem, 4018735), Boc-IEGR-AMC (Bachem, 4004961), and Boc-Z-LR-AMC (Bio-Techne, ES008)

(3) Divergent responses to SARS-CoV-2 infection in bronchial epithelium with pre-existing respiratory diseasesiScienceMarch 21, 2025Justine Oliva, Manon Ruffin, Claire Calmel, Aurélien Gibeaud, Andrés Pizzorno, Clémence Gaudin, Solenne Chardonnet, Viviane de Almeida Bastos, Manuel Rosa-Calatrava, Antoine Soulé, et al.12) and pwCF (n = 12) were incubated with a fluorogenic peptide substrate (Boc-Gln-Ala-Arg-AMC; Ref ES014; R&D Systems Minneapolis, MN, USA, 200 mM in Opti-MEM) at 37°C, 5% CO2 for 1 h. The fluorescence intensity

(4) Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanomaNat CommunMarch 10, 2025Manon Bulliard, Katarina Pinjusic, Laura Iacobucci, Céline Schmuziger, Nadine Fournier, Daniel B. Constamcitrate, pH 7.5) for 1 hr at 37 °C, together with 0.1 mM fluorogenic Boc-QAR-AMC substrate (R&D Systems, ES014). 0.5 ng of rKLK12 was incubated in 100 µL KLK12 Assay buffer (100 mM Tris•HCl pH 7.5 containing 150

(5) First-generation high-affinity ST14 radiopharmaceutical: Design, synthesis, and preclinical PET imaging evaluation for pancreatic cancer detectionBioorganic chemistryJanuary 1, 2025Peng T, Wen J, Huang G, Zhao H, Liu J.

(6) TMPRSS2 is a functional receptor for human coronavirus HKU1NatureDecember 1, 2023Saunders N, Fernandez I, Planchais C, Michel V, Rajah MM, Baquero Salazar E, Postal J, Porrot F, Guivel-Benhassine F, Blanc C, et al.recorded. TMPRSS2 enzymatic activity Enzymatic activity was measured using BOC-QAR-AMC (R&D Systems, ES014), a substrate of TMPRSS2 that fluoresces when cleaved. For wild type and mutant TMPRSS2, cells were

(7) The Transmembrane Protease Serine 2 (TMPRSS2) Non-Protease Domains Regulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike-Mediated Virus EntryVirusesOctober 19, 2023Strobelt R, Adler J, Shaul Y.

(8) Transmembrane serine protease TMPRSS2 implicated in SARS-CoV-2 infection is autoactivated intracellularly and requires N-glycosylation for regulationThe Journal of biological chemistryDecember 1, 2022Zhang Y, Sun S, Du C, Hu K, Zhang C, Liu M, Wu Q, Dong N.and incubated with a fluorogenic peptide substrate (Boc-Gln-Ala-Arg-AMC; R&D Systems; catalog no.: ES014) (200 mM in Opti-MEM) at room temperature for 1 h. Fluorescent intensity was monitored in a plate reader

(9) Selective targeting of metastatic ovarian cancer using an engineered anthrax prodrug activated by membrane-anchored serine proteasesProceedings of the National Academy of Sciences of the United States of AmericaJuly 12, 2022Duru N, Pawar NR, Martin EW, Buzza MS, Conway GD, Lapidus RG, Liu S, Reader J, Rao GG, Roque DM, et al.

(10) Transmembrane serine protease 2 (TMPRSS2) proteolytically activates the epithelial sodium channel (ENaC) by cleaving the channel's γ-subunitThe Journal of biological chemistryJune 1, 2022Sure F, Bertog M, Afonso S, Diakov A, Rinke R, Madej MG, Wittmann S, Gramberg T, Korbmacher C, Ilyaskin AV.

(11) A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeuticNatureMay 1, 2022Shapira T, Monreal IA, Dion SP, Buchholz DW, Imbiakha B, Olmstead AD, Jager M, Désilets A, Gao G, Martins M, et al.

(12) Functionally impaired isoforms regulate TMPRSS6 proteolytic activityPloS oneJanuary 1, 2022Dion SP, Désilets A, Lemieux G, Leduc R.

(13) Potential differences in cleavage of the S protein and type-1 interferon together control human coronavirus infection, propagation, and neuropathology within the central nervous systemJournal of virologyApril 26, 2021Le Coupanec A, Desforges M, Kaufer B, Dubeau P, Côté M, Talbot PJ.recommended speciﬁcations provided by the manufacturer with ﬂuorogenic substrate (catalog no. ES008 and ES014; all reagents were from R&D Systems). For furin, kindly provided by Robert Day, Km and Vmax were previously

(14) Structure-activity relationship studies of dipeptide-based hepsin inhibitors with Arg bioisosteresBioorganic chemistryFebruary 1, 2021Kwon H, Ha H, Jeon H, Jang J, Son SH, Lee K, Park SK, Byun Y.

(15) Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2bioRxiv : the preprint server for biologyOctober 7, 2020Azouz NP, Klingler AM, Callahan V, Akhrymuk IV, Elez K, Raich L, Henry BM, Benoit JL, Benoit SW, Noé F, et al.

(16) A Novel Serine Protease Inhibitor PE-BBI Ameliorates Cockroach Extract-Mediated Airway Epithelial Barrier DysfunctionBiomoleculesMarch 28, 2020Reihill JA, Ouyang X, Yang Z, Douglas LEJ, Zhou M, Chen T, Martin SL.

(17) Design and synthesis of dye-conjugated hepsin inhibitorsBioorganic chemistryAugust 1, 2019Kim K, Kwon H, Choi D, Lim T, Minn I, Son SH, Byun Y.

(18) Functional diversity of TMPRSS6 isoforms and variants expressed in hepatocellular carcinoma cell linesScientific reportsAugust 22, 2018Dion SP, Béliveau F, Morency LP, Désilets A, Najmanovich R, Leduc R.

(19) Transcriptome analysis reveals TMPRSS6 isoforms with distinct functionalitiesJournal of cellular and molecular medicineApril 1, 2018Dion SP, Béliveau F, Désilets A, Ghinet MG, Leduc R.

(20) Kempopeptin C, a Novel Marine-Derived Serine Protease Inhibitor Targeting Invasive Breast CancerMarine drugsSeptember 16, 2017Al-Awadhi FH, Salvador LA, Law BK, Paul VJ, Luesch H.period, 50 µL of the 50 µM substrate solution (Boc-Gln-Ala-Arg-AMC) (R&D Systems, Minneapolis, MN, USA; ES014) were added to each well, and the enzyme activity was monitored by measuring the increase in fluorescence

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Boc-QAR-AMC Fluorogenic Peptide Substrate from R&D Systems, a Bio-Techne Brand

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Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (22)

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Boc-QAR-AMC Fluorogenic Peptide Substrate from R&D Systems, a Bio-Techne Brand

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