FGF-21 Protein 2539-FG-025/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemFGF-21 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $362.00Supplier Page View Company Product Page
Catalog Number2539-FG-025/CF
FormatLyophilized from a 0.2 µm filtered solution in MES, Na2SO4, EDTA and DTT
SpeciesHuman
Size25 ug (also 50 ug, 200 ug, 1 mg)
Molecule NameFGF-21
NCBI Full Gene Namefibroblast growth factor 21
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human FGF-21 Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
Molecular WeightObserved: 24 kDa, reducing conditions
Theoretical: 20.2 kDa
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining

Specifications/Features

Available conjugates: Sizes Available: 25 ug (also 50 ug, 200 ug, 1 mg)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signalingCell Reports MedicineJune 17, 2025Sobuj Mia, Georgios Siokatas, Rafailia Sidiropoulou, Matthew Hoffman, Konstantinos Fragkiadakis, Eftychia Markopoulou, Mahmoud I. Elesawy, Rajika Roy, Scott Blair, Yasuhide Kuwabara, et al.penicillin/streptomycin mix at 37°C and 5%CO2. AC16 cells were treated with rh-FGF21 (R&D Systems, catalog # 2539-FG-025/CF) at 10 nM concentration for 24 h before cells were harvested for mRNA and protein purification. For

(2) Soluble α-klotho and heparin modulate the pathologic cardiac actions of fibroblast growth factor 23 in chronic kidney diseaseKidney internationalAugust 1, 2022Yanucil C, Kentrup D, Campos I, Czaya B, Heitman K, Westbrook D, Osis G, Grabner A, Wende AR, Vallejo J, et al.(237-F5/CF); human FGF7 (251-KG/CF); human FGF8b (423-F8/CF); human FGF19 (969FG025/CF); human FGF21 (2539FG025/CF); human FGF23 (2604FG025/CF); mouse FGF23 (2629FG025/CF); human FGFR1c (658FR050); human FGFR2c (712FR050);

(3) FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetesScientific reportsMay 5, 2022Yanucil C, Kentrup D, Li X, Grabner A, Schramm K, Martinez EC, Li J, Campos I, Czaya B, Heitman K, et al.concentric cardiac hypertrophy. Methods Antibodies and recombinant proteins We used human FGF21 (2539-FG-025/CF, R&D Systems, United States), mouse FGF21 (8409-FG-025/CF, R&D Systems), human soluble β-klotho (5889-KB-050/CF,

(4) Tethered-variable CL bispecific IgG: an antibody platform for rapid bispecific antibody screeningProtein Engineering, Design and SelectionSeptember 1, 2017Hok Seon Kim, Diana Ronai Dunshee, Angie Yee, Raymond K Tong, Ingrid Kim, Farzam Farahi, Jo-Anne Hongo, James A Ernst, Junichiro Sonoda, Christoph Spiesspurified via affinity columns to monodispersity. Human FGF21 protein was acquired from R&D Systems (cat# 2539-FG-025/CF, Minneapolis, MN). Results VL-HC fusion and CL expression in trans solves cognate light chain pairing

(5) Peripherally derived FGF21 promotes remyelination in the central nervous systemThe Journal of clinical investigationSeptember 1, 2017Kuroda M, Muramatsu R, Maedera N, Koyama Y, Hamaguchi M, Fujimura H, Yoshida M, Konishi M, Itoh N, Mochizuki H, et al.

(6) Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21The Journal of biological chemistryMarch 11, 2016Dunshee DR, Bainbridge TW, Kljavin NM, Zavala-Solorio J, Schroeder AC, Chan R, Corpuz R, Wong M, Zhou W, Deshmukh G, et al.

(7) Unliganded fibroblast growth factor receptor 1 forms density-independent dimersThe Journal of biological chemistryOctober 2, 2015Comps-Agrar L, Dunshee DR, Eaton DL, Sonoda J.

(8) Circulating αKlotho influences phosphate handling by controlling FGF23 productionThe Journal of clinical investigationDecember 1, 2012Smith RC, O'Bryan LM, Farrow EG, Summers LJ, Clinkenbeard EL, Roberts JL, Cass TA, Saha J, Broderick C, Ma YL, et al.

(9) FGF19 regulates cell proliferation, glucose and bile acid metabolism via FGFR4-dependent and independent pathwaysPloS oneMarch 18, 2011Wu AL, Coulter S, Liddle C, Wong A, Eastham-Anderson J, French DM, Peterson AS, Sonoda J.

(10) Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancerThe American journal of pathologyNovember 1, 2010Tomlinson DC, Knowles MA.

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Recombinant Human FGF-21 Protein, CF

FGF-21 Protein

FGF-21 Protein

FGF-21 Protein

FGF-21 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (10)

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FGF-21 Protein from R&D Systems, a Bio-Techne Brand

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