Recombinant Human FGF-23 Protein 2604-FG-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human FGF-23 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $351.00Supplier Page View Company Product Page
Catalog Number2604-FG-025
SpeciesHuman
Molecule NameFGF-23
Size25 ug
NCBI Full Gene Namefibroblast growth factor 23
NCBI Gene AliasesADHR, HPDR2, FGFN, HFTC2, PHPTC, HYPF
FormatLyophilized from a 0.2 µm filtered solution in MOPS, Na2SO4, EDTA and DTT with BSA as a carrier protein
Purity>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 29-34 kDa, reducing conditions
Theoretical: 26.1 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human FGF-23 Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, 2 to 8 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Noncanonical RGS14 structural determinants control hormone-sensitive NPT2A-mediated phosphate transportThe Biochemical journalFebruary 5, 2025Sneddon WB, Ramineni S, Van Doorn GE, Hepler JR, Friedman PA.to as FGF23), which is resistant to furin cleavage and inactivation, was obtained from R&D Systems (2604-FG-025). Human RGS14 constructs FLAG-tagged deletion mutants of RGS14 were created using the full-length

(2) ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stressRedox biologyMay 1, 2024Jung YS, Radhakrishnan K, Hammad S, Müller S, Müller J, Noh JR, Kim J, Lee IK, Cho SJ, Kim DK, et al.

(3) Molecular Interaction of Soluble Klotho with FGF23 in the Pathobiology of Aortic Valve Lesions Induced by Chronic Kidney DiseaseInternational journal of biological sciencesJanuary 1, 2024The E, Zhai Y, Yao Q, Ao L, Fullerton DA, Meng X.

(4) A New Approach to the Quantification of Fibroblast Growth Factor 23-An Array Surface Plasmon Resonance Imaging BiosensorInternational journal of molecular sciencesOctober 18, 2023Tokarzewicz A, Ołdak Ł, Młynarczyk G, Klekotka U, Gorodkiewicz E.

(5) Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport and cause congenital hypophosphatemiaBiochemical JournalMay 17, 2023W. Bruce Sneddon, Peter A. Friedman, Tatyana Mamonovahenceforth as FGF23), which is resistant to furin cleavage and inactivation, was obtained from R&D Systems (2604-FG-025). Antibodies Antibodies Rabbit polyclonal anti-NHERF1 (ab3452) and monoclonal anti-NHERF1 (Abcam ab31111)

(6) Mutations in an unrecognized internal NPT2A PDZ motif disrupt phosphate transport causing congenital hypophosphatemiabioRxiv : the preprint server for biologyMarch 7, 2023Sneddon WB, Friedman PA, Mamonova T.

(7) Soluble α-klotho and heparin modulate the pathologic cardiac actions of fibroblast growth factor 23 in chronic kidney diseaseKidney internationalAugust 1, 2022Yanucil C, Kentrup D, Campos I, Czaya B, Heitman K, Westbrook D, Osis G, Grabner A, Wende AR, Vallejo J, et al.

(8) RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding proteinThe Journal of biological chemistryMay 1, 2022Friedman PA, Sneddon WB, Mamonova T, Montanez-Miranda C, Ramineni S, Harbin NH, Squires KE, Gefter JV, Magyar CE, Emlet DR, et al.which is resistant to furin cleavage and inactivation, was obtained from R&D Systems (catalog no.: 2604-FG-025). PF-06869206 (catalog no.: PZ0389) was purchased from MilliporeSigma. Human genetic variants and constructs Human

(9) Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturationNature communicationsNovember 29, 2021Heil J, Olsavszky V, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber H, Zierow J, et al.

(10) Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney diseaseThe Journal of biological chemistryMarch 6, 2020Zhong X, Jagarlapudi S, Weng Y, Ly M, Rouse JC, McClure K, Ishino T, Zhang Y, Sousa E, Cohen J, et al.

(11) FGF23-Mediated Activation of Local RAAS Promotes Cardiac Hypertrophy and FibrosisInternational journal of molecular sciencesSeptember 18, 2019Böckmann I, Lischka J, Richter B, Deppe J, Rahn A, Fischer DC, Heineke J, Haffner D, Leifheit-Nestler M.

(12) Prolonged exposure to 1,25(OH)₂D₃ and high ionized calcium induces FGF-23 production in intestinal epithelium-like Caco-2 monolayer: A local negative feedback for preventing excessive calcium transportArchives of biochemistry and biophysicsFebruary 15, 2018Rodrat M, Wongdee K, Panupinthu N, Thongbunchoo J, Teerapornpuntakit J, Krishnamra N, Charoenphandhu N.

(13) PAI-1 is a critical regulator of FGF23 homeostasisScience AdvancesSeptember 13, 2017Mesut Eren, Aaron T. Place, Paul M. Thomas, Panagiotis Flevaris, Toshio Miyata, Douglas E. VaughanR179Q mutation (native FGF23 is not available commercially) was obtained from R&D Systems (catalog no. 2604-FG-025). Plasma levels of FGF23 were determined using the following ELISA kits from Immutopics Inc.: Mouse/Rat

(14) Fibroblast growth factor 23 weakens chemotaxis of human blood neutrophils in microfluidic devicesScientific reportsJune 8, 2017Yang K, Peretz-Soroka H, Wu J, Zhu L, Cui X, Zhang M, Rigatto C, Liu Y, Lin F.

(15) α-Klotho expression determines nitric oxide synthesis in response to FGF-23 in human aortic endothelial cellsPloS oneJanuary 1, 2017Chung CP, Chang YC, Ding Y, Lim K, Liu Q, Zhu L, Zhang W, Lu TS, Molostvov G, Zehnder D, et al.

(16) A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemiaScience signalingNovember 22, 2016Xiao Z, Riccardi D, Velazquez HA, Chin AL, Yates CR, Carrick JD, Smith JC, Baudry J, Quarles LD.

(17) Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate TransportThe Journal of biological chemistrySeptember 2, 2016Sneddon WB, Ruiz GW, Gallo LI, Xiao K, Zhang Q, Rbaibi Y, Weisz OA, Apodaca GL, Friedman PA.

(18) Regulation of CYP27B1 mRNA Expression in Primary Human OsteoblastsCalcified tissue internationalAugust 1, 2016van der Meijden K, van Essen HW, Bloemers FW, Schulten EA, Lips P, Bravenboer N.

(19) FGF-23 is a negative regulator of prenatal and postnatal erythropoiesisThe Journal of biological chemistryApril 4, 2014Coe LM, Madathil SV, Casu C, Lanske B, Rivella S, Sitara D.

(20) Direct, acute effects of Klotho and FGF23 on vascular smooth muscle and endotheliumPloS oneJanuary 1, 2014Six I, Okazaki H, Gross P, Cagnard J, Boudot C, Maizel J, Drueke TB, Massy ZA.

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FGF-23 Protein

FGF-23 Protein

FGF-23 Protein

Recombinant Human FGF-23 Protein from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human FGF-23 Protein from R&D Systems, a Bio-Techne Brand

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