alpha-L-Iduronidase/IDUA Protein 4119-GH-010 from R&D Systems, a Bio-Techne Brand

Product Specs
Itemalpha-L-Iduronidase/IDUA Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $568.00Supplier Page View Company Product Page
Catalog Number4119-GH-010
FormatSupplied as a 0.2 µm filtered solution in Sodium Acetate, NaCl and Glycerol
SpeciesHuman
Size10 ug
Molecule Namealpha-L-Iduronidase/IDUA
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 83 kDa, reducing conditions
Theoretical: 71 kDa
ApplicationsEnzyme Activity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human alpha-L-Iduronidase/IDUA Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening
NCBI Full Gene Namealpha-L-iduronidase
NCBI Gene AliasesIDA, MPS1, MPSI

Specifications/Features

Available conjugates: Sizes Available: 10 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Rescue of neurologic disease in mucopolysaccharidosis type II mice via AAV-mediated liver delivery of brain-penetrating iduronate-2-sulfataseNeurotherapeuticsOctober 1, 2025Xiu Jin, Qin Ye, Xiaoyi Wu, Jing Su, Li Song, Jiamei Fu, Qiuxia Xu, Min Luo, Fanfei Liu, Chengda Ren, et al.lead acetate, pH 5.0) at 37 °C for 4 h. Subsequently, 1 μg/mL human α-l-iduronidase (R&D Systems, 4119-GH-010) was added, and the reaction was allowed to proceed overnight. The reaction was terminated by adding

(2) Non-invasive intravenous administration of AAV9 transducing iduronate sulfatase leads to global metabolic correction and prevention of neurologic deficits in a mouse model of Hunter syndromeMolecular genetics and metabolism reportsMarch 1, 2023Laoharawee K, Podetz-Pedersen KM, Nguyen TT, Singh SM, Smith MC, Belur LR, Low WC, Kozarsky KF, McIvor RS.into the reaction tube to stop the first-step reaction. Ten μL of 5 μg/mL Iduronidase (IDUA; Cat. #4119-GH-010, R&D Systems, MN) was immediately added to start the second-step reaction, and then incubating overnight

(3) Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type IICell death & diseaseJuly 24, 2018Osaki Y, Saito A, Kanemoto S, Kaneko M, Matsuhisa K, Asada R, Masaki T, Orii K, Fukao T, Tomatsu S, et al.

(4) Dose-Dependent Prevention of Metabolic and Neurologic Disease in Murine MPS II by ZFN-Mediated In Vivo Genome EditingMolecular therapy : the journal of the American Society of Gene TherapyApril 4, 2018Laoharawee K, DeKelver RC, Podetz-Pedersen KM, Rohde M, Sproul S, Nguyen HO, Nguyen T, St Martin SJ, Ou L, Tom S, et al.stop IDS enzyme activity. A final concentration of 1 μg/mL iduronidase (IDUA) (R&D Systems; cat. no. 4119-GH-010) was added to start the second-step reaction and incubated overnight at 37°C. Reactions were terminated

(5) Fast, sensitive method for trisaccharide biomarker detection in mucopolysaccharidosis type 1Scientific reportsFebruary 27, 2018Makino E, Klodnitsky H, Leonard J, Lillie J, Lund TC, Marshall J, Nietupski J, Orchard PJ, Miller WP, Phaneuf C, et al.(Cambridge, MA) was used. For in vitro studies, recombinant human α-L-iduronidase/IDUA Protein (CF 4119-GH-010), recombinant human iduronate 2-sulfatase protein (CF 2449-SU), and recombinant mouse sulfamidase/SGSH Protein (CF

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Recombinant Human alpha-L-Iduronidase/IDUA Protein, CF

alpha-L-Iduronidase/IDUA Protein

alpha-L-Iduronidase/IDUA Protein

alpha-L-Iduronidase/IDUA Protein

alpha-L-Iduronidase/IDUA Protein from R&D Systems, a Bio-Techne Brand

Description

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (5)

Reviews

alpha-L-Iduronidase/IDUA Protein from R&D Systems, a Bio-Techne Brand

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