Recombinant Human FAP Protein, CF 3715-SE-010 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human FAP Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $404.00Supplier Page View Company Product Page
Catalog Number3715-SE-010
Size10 ug
FormatSupplied as a 0.2 µm filtered solution in Tris, NaCl and Glycerol
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
ApplicationsEnzyme Activity
Conjugate/TagUnconjugated
SpeciesHuman
Molecule NameFibroblast Activation Protein alpha/FAP
Source/Expression SystemSf 21 (baculovirus)-derived Recombinant Human FAP Protein, CF
Molecular WeightObserved: 85 kDa, reducing conditions
Theoretical: 86 kDa
NCBI Full Gene Namefibroblast activation protein alpha
NCBI Gene AliasesSIMP, DPPIV, FAPA, FAPalpha
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) AND-gated protease-activated nanosensors for programmable detection of anti-tumour immunityNature nanotechnologyMarch 1, 2025Sivakumar A, Phuengkham H, Rajesh H, Mac QD, Rogers LC, Silva Trenkle AD, Bawage SS, Hincapie R, Li Z, Vainikos S, et al.

(2) Development of Zalfermin, a Long-Acting Proteolytically Stabilized FGF21 AnalogJournal of medicinal chemistryJuly 25, 2024Sass-Ørum K, Tagmose TM, Olsen J, Sjölander A, Wahlund PO, Han D, Vegge A, Reedtz-Runge S, Wang Z, Gao X, et al.of (1), (15), and (5) by FAP Five μM of FGF21 analog was incubated in duplicate with FAP (R&D Systems, 3715-SE-010) at pH 7.4 (50 mM Tris, pH 7.4, 100 mM NaCl, 0.05% Tween20) at 37 °C. Incubations were conducted at

(3) Fibroblast activation protein regulates natural killer cell migration, extravasation and tumor infiltrationResearch squareDecember 19, 2023Weiner L, Fitzgerald A, Maynard R, Marcisak E, Nasir A, Glasgow E, Jablonski S, Van Der Veken P, Pearson G, Eisman S, et al.

(4) A bioactivated in vivo assembly nanotechnology fabricated NIR probe for small pancreatic tumor intraoperative imagingNature communicationsJanuary 20, 2022Ren H, Zeng XZ, Zhao XX, Hou DY, Yao H, Yaseen M, Zhao L, Xu WH, Wang H, Li LL.

(5) Fibroblast Activation Protein Specific Optical Imaging in Non-Small Cell Lung CancerFrontiers in oncologyJanuary 1, 2022Mathieson L, O'Connor RA, Stewart H, Shaw P, Dhaliwal K, Williams GOS, Megia-Fernandez A, Akram AR.

(6) DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinomaJournal for immunotherapy of cancerNovember 1, 2021Fitzgerald AA, Wang S, Agarwal V, Marcisak EF, Zuo A, Jablonski SA, Loth M, Fertig EJ, MacDougall J, Zhukovsky E, et al.mM Tris, 1 M NaCl, 1 mg/mL BSA, pH 7.5). A standard curve was generated using rFAP (R&D Systems, cat#3715-SE-010) or rDPP4 (R&D Systems, cat#9168-SE) and 50 µL of recombinant protein plus 50 µL of substrate was added

(7) Simultaneous Engagement of Tumor and Stroma Targeting Antibodies by Engineered NK-92 Cells Expressing CD64 Controls Prostate Cancer GrowthCancer immunology researchNovember 1, 2021Hintz HM, Snyder KM, Wu J, Hullsiek R, Dahlvang JD, Hart GT, Walcheck B, LeBeau AM.diversity of 1x109 was used to identify clones against recombinant human FAP (R&D Systems, catalog no. 3715-SE-010). Anti-TROP2 was generated as previously described [26]. The heavy and light chain variable domains

(8) An improved production and purification protocol for recombinant soluble human fibroblast activation protein alphaProtein expression and purificationMay 1, 2021Xi CR, Di Fazio A, Nadvi NA, Xiang MSW, Zhang HE, Deshpande C, Chen Y, Tabar MS, Wang XM, Bailey CG, et al.

(9) Discovery of a novel fibroblast activation protein (FAP) inhibitor, BR103354, with anti-diabetic and anti-steatotic effectsScientific reportsDecember 4, 2020Cho JM, Yang EH, Quan W, Nam EH, Cheon HG.

(10) Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug TargetCell reportsOctober 13, 2020Wei H, Xu Y, Wang Y, Xu L, Mo C, Li L, Shen B, Sun Y, Cheng P, Yang L, et al.

(11) RIPK3-MLKL-Mediated Neutrophil Death Requires Concurrent Activation of Fibroblast Activation Protein-αJournal of immunology (Baltimore, Md. : 1950)September 15, 2020Wang X, Gessier F, Perozzo R, Stojkov D, Hosseini A, Amirshahrokhi K, Kuchen S, Yousefi S, Lötscher P, Simon HU.

(12) Introduction of Z-GP scaffold into procarbazine reduces spermatoxicity and myelosuppressionBioorganic chemistryMarch 1, 2019Wang R, Zhang C, Zheng C, Li H, Xie X, Jin Y, Liu Z, Chen H.

(13) Tumor-targeting efficacy of a BF211 prodrug through hydrolysis by fibroblast activation protein-αActa pharmacologica SinicaMarch 1, 2018Chai XP, Sun GL, Fang YF, Hu LH, Liu X, Zhang XW.

(14) Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agentsThe Journal of clinical investigationOctober 2, 2017Chen M, Lei X, Shi C, Huang M, Li X, Wu B, Li Z, Han W, Du B, Hu J, et al.

(15) Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart diseasePloS oneJanuary 1, 2017Uitte de Willige S, Keane FM, Bowen DG, Malfliet JJMC, Zhang HE, Maneck B, McCaughan GW, Leebeek FWG, Rijken DC, Gorrell MD.

(16) Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21The Journal of biological chemistryMarch 11, 2016Dunshee DR, Bainbridge TW, Kljavin NM, Zavala-Solorio J, Schroeder AC, Chan R, Corpuz R, Wong M, Zhou W, Deshmukh G, et al.

(17) The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node MetastasesPloS oneJanuary 1, 2016Errarte P, Guarch R, Pulido R, Blanco L, Nunes-Xavier CE, Beitia M, Gil J, Angulo JC, López JI, Larrinaga G.Eclipse 80i microscope (Tokyo, Japan). Western-blot analysis 1 μg of human recombinant FAP protein (CF 3715-SE-010, R&D Systems) was loaded in a SDS-PAGE gel and transferred onto a PVDF membrane. The band was marked

(18) Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behaviorMatrix biology : journal of the International Society for Matrix BiologyJune 1, 2014Grindel BJ, Martinez JR, Pennington CL, Muldoon M, Stave J, Chung LW, Farach-Carson MC.

(19) Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organsFEBS open bioJanuary 1, 2013Keane FM, Yao TW, Seelk S, Gall MG, Chowdhury S, Poplawski SE, Lai JH, Li Y, Wu W, Farrell P, et al.

(20) Radioimmunotherapy of fibroblast activation protein positive tumors by rapidly internalizing antibodiesClinical cancer research : an official journal of the American Association for Cancer ResearchNovember 15, 2012Fischer E, Chaitanya K, Wüest T, Wadle A, Scott AM, van den Broek M, Schibli R, Bauer S, Renner C.

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Recombinant Human FAP Protein, CF

Fibroblast Activation Protein alpha/FAP Protein

Fibroblast Activation Protein alpha/FAP Protein

Fibroblast Activation Protein alpha/FAP Protein

Recombinant Human FAP Protein, CF from R&D Systems, a Bio-Techne Brand

Description

R&D Systems, a Bio-Techne Brand

Citations (21)

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Recombinant Human FAP Protein, CF from R&D Systems, a Bio-Techne Brand

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