IL-36 gamma/IL-1F9 (aa 18-169) Protein 6835-IL-010 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-36 gamma/IL-1F9 (aa 18-169) Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $408.00Supplier Page View Company Product Page
Catalog Number6835-IL-010
Source/Expression SystemE. coli-derived Recombinant Human IL-36 gamma/IL-1F9 (aa 18-169) Protein
Molecule NameIL-36 gamma/IL-1F9
SpeciesHuman
Size10 ug
NCBI Full Gene Nameinterleukin 36 gamma
NCBI Gene AliasesIL-1F9, IL-1H1, IL1H1, IL1F9, IL-1RP2, IL1RP2, IL1E
FormatLyophilized from a 0.2 µm filtered solution in MOPS, NaCl, TCEP and EDTA with BSA as a carrier protein
Purity>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 17 kDa, reducing conditions
Theoretical: 17 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 10 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Dynamic neutrophil-keratinocyte communication network centered on IL-36/TNFSF15 responses characterizes inflammatory responses in generalized pustular psoriasisNature communicationsDecember 23, 2025Jiang R, Kirma J, Fox J, Xing X, Wang J, Sarkar MK, Bogle R, Do T, Coon A, Cole C, et al.co-culture with N/TERTs and neutrophils, N/TERTs were stimulated with activated IL-36γ (R&D Systems, cat. 6835-IL-010, 100 ng/mL) and IL-1β (Sino, cat. 10139-HNAE, 50 ng/mL) for 8 h to induce an intracellular inflammatory

(2) Targeting IL-1 controls refractory pityriasis rubra pilarisScience advancesJuly 5, 2024Schmauch E, Severin Y, Xing X, Mangold A, Conrad C, Johannsen P, Kahlenberg JM, Mellett M, Navarini A, Nobbe S, et al.

(3) IL-36γ and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell DeathAdvanced science (Weinheim, Baden-Wurttemberg, Germany)October 1, 2021Wang P, Yang W, Guo H, Dong HP, Guo YY, Gan H, Wang Z, Cheng Y, Deng Y, Xie S, et al.glucose‐free DMEM (1mL per well) for another 16 h followed by adding IL‐36γ (20 ng per well, 6996‐IL‐010 and 6835‐IL‐010 for mouse and human IL‐36γ respectively, R&D system) with or without IL‐36Ra (20 ng per well, 210–36RA,

(4) The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasisThe Journal of clinical investigationNovember 2, 2020Müller A, Dickmanns A, Resch C, Schäkel K, Hailfinger S, Dobbelstein M, Schulze-Osthoff K, Kramer D.

(5) IL-36γ regulates mediators of tissue homeostasis in epithelial cellsCytokineJuly 1, 2019Heath JE, Scholz GM, Veith PD, Reynolds EC.

(6) Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasisDrug design, development and therapyJanuary 1, 2019Guo J, Tu J, Hu Y, Song G, Yin Z.(2320-IL-025, R&D Systems, Inc., Minneapolis, MN, USA), 100 ng/ mL recombinant human truncated (T)-IL-36γ (6835-IL010, R&D Systems, Inc.), 10 ng/mL recombinant human NE (R&D Systems, Inc.), 10 ng/mL NE + FL-IL-36γ, 100

(7) IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatmentCell death & diseaseOctober 30, 2018Mercurio L, Morelli M, Scarponi C, Eisenmesser EZ, Doti N, Pagnanelli G, Gubinelli E, Mazzanti C, Cavani A, Ruvo M, et al.

(8) Intramuscular vaccination of guinea pigs with the live-attenuated human herpes simplex vaccine VC2 stimulates a transcriptional profile of vaginal Th17 and regulatory Tr1 responsesVaccineMay 11, 2018Stanfield BA, Rider PJF, Caskey J, Del Piero F, Kousoulas KG.

(9) RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene SignatureFrontiers in immunologyJanuary 1, 2018Swindell WR, Beamer MA, Sarkar MK, Loftus S, Fullmer J, Xing X, Ward NL, Tsoi LC, Kahlenberg MJ, Liang Y, et al.with recombinant IL-1 beta (10 μg/ml; R&D Systems # 201-LB-025), IL-36 gamma (10 μg/ml; R&D Systems # 6835-IL-010), IFN-gamma (50 μg/ml; R&D Systems # 285-IF-100), IL-17A (20 μg/ml; R&D Systems # 317-ILB-050), and/or

(10) IL-36γ inhibits differentiation and induces inflammation of keratinocyte via Wnt signaling pathway in psoriasisInternational journal of medical sciencesJanuary 1, 2017Wang W, Yu X, Wu C, Jin H.

(11) Structural and Functional Attributes of the Interleukin-36 ReceptorThe Journal of biological chemistryAugust 5, 2016Yi G, Ybe JA, Saha SS, Caviness G, Raymond E, Ganesan R, Mbow ML, Kao CC.

(12) Signal Transduction and Intracellular Trafficking by the Interleukin 36 ReceptorThe Journal of biological chemistrySeptember 25, 2015Saha SS, Singh D, Raymond EL, Ganesan R, Caviness G, Grimaldi C, Woska JR Jr, Mennerich D, Brown SE, Mbow ML, et al.

(13) Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injuryScientific reportsFebruary 17, 2015Scheiermann P, Bachmann M, Härdle L, Pleli T, Piiper A, Zwissler B, Pfeilschifter J, Mühl H.

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IL-36 gamma/IL-1F9 (aa 18-169) Protein

IL-36 gamma/IL-1F9 (aa 18-169) Protein

IL-36 gamma/IL-1F9 (aa 18-169) Protein

IL-36 gamma/IL-1F9 (aa 18-169) Protein

IL-36 gamma/IL-1F9 (aa 18-169) Protein

IL-36 gamma/IL-1F9 (aa 18-169) Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (13)

Reviews

IL-36 gamma/IL-1F9 (aa 18-169) Protein from R&D Systems, a Bio-Techne Brand

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