Recombinant Human PSGL-1/CD162 Fc Chimera Protein, CF 3345-PS-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human PSGL-1/CD162 Fc Chimera Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $454.00Supplier Page View Company Product Page
Catalog Number3345-PS-050
SpeciesHuman
FormatLyophilized from a 0.2 µm filtered solution in Tris and NaCl
Molecule NamePSGL-1/CD162
Size50 ug
Source/Expression SystemCHO-derived Recombinant Human PSGL-1/CD162 Fc Chimera Protein, CF
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 100-150 kDa, reducing conditions
Theoretical: 52.6 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Full Gene Nameselectin P ligand
NCBI Gene AliasesCD162, CLA, PSGL-1, PSGL1

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Preclinical Efficacy of VTX-0811: A Humanized First-in-Class PSGL-1 mAb Targeting TAMs to Suppress Tumor GrowthCancersAugust 6, 2024Novobrantseva T, Manfra D, Ritter J, Razlog M, O'Nuallain B, Zafari M, Nowakowska D, Basinski S, Phennicie RT, Nguyen PA, et al.

(2) Oligomer-guided recognition of two fucan sulfate from Bohadschia argus and inhibition of P-selectin binding to its ligandCarbohydrate polymersOctober 1, 2023Ruzemaimaiti D, Sun H, Zhang J, Xu C, Chen L, Yin R, Zhao J.

(3) Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfationCell Chemical BiologyAugust 1, 2023Christoffer K. Goth, Akul Y. Mehta, Alyssa M. McQuillan, Kelly J. Baker, Melinda S. Hanes, Simon S. Park, Kathrin Stavenhagen, Gertrud M. Hjortø, Jamie Heimburg-Molinaro, Elliot L. Chaikof, et al.Recombinant Human P-Selectin/CD62P Protein,R&D systems,ADP3 "Recombinant Human PSGL-1/CD162 Fc Chimera Protein, CF",R&D systems,3345-PS-050 PNGase F,New England Biolabs (NEB),P0704L Sequencing Grade Modified Trypsin,Promega,V5111 Endoproteinase Asp-N from Pseudomonas fragi mutant strain

(4) A previously uncharacterized O-glycopeptidase from Akkermansia muciniphila requires the Tn-antigen for cleavage of the peptide bondThe Journal of biological chemistryOctober 1, 2022Medley BJ, Leclaire L, Thompson N, Mahoney KE, Pluvinage B, Parson MAH, Burke JE, Malaker S, Wakarchuk W, Boraston AB.

(5) Therapeutic implementation in arterial thrombosis with pulmonary administration of fucoidan microparticles containing acetylsalicylic acidInternational journal of pharmaceuticsJune 25, 2022Saito MS, Zatta KC, Sathler PC, Furtado PS, C O Miguel N, Frattani FS, Berger M, Lavayen V, Pohlmann AR, Guterres SS.

(6) Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferencesThe Journal of biological chemistryMay 1, 2022Shon DJ, Fernandez D, Riley NM, Ferracane MJ, Bertozzi CR.

(7) Quantification of fast molecular adhesion by fluorescence footprintingScience advancesAugust 1, 2021Yasunaga AB, Li ITS.beads (6.76 μm diameter, Spherotech, PGP-60-5) were functionalized with PSGL-1-Fc Chimera (R&D Systems, 3345-PS-050) as described previously (19). Ten microliters of stock beads (0.5%, w/v) was washed twice with phosphate-buffered

(8) An engineered antibody binds a distinct epitope and is a potent inhibitor of murine and human VISTAScientific reportsSeptember 16, 2020Mehta N, Maddineni S, Kelly RL, Lee RB, Hunter SA, Silberstein JL, Parra Sperberg RA, Miller CL, Rabe A, Labanieh L, et al.

(9) The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endotheliumPloS oneJanuary 1, 2020Lam FW, Brown CA, Valladolid C, Emebo DC, Palzkill TG, Cruz MA.

(10) The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucinsProceedings of the National Academy of Sciences of the United States of AmericaApril 9, 2019Malaker SA, Pedram K, Ferracane MJ, Bensing BA, Krishnan V, Pett C, Yu J, Woods EC, Kramer JR, Westerlind U, et al.

(11) Synthesis of Human Neutrophil Extracellular Traps Contributes to Angiopoietin-Mediated In Vitro Proinflammatory and Proangiogenic ActivitiesJournal of immunology (Baltimore, Md. : 1950)June 1, 2018Lavoie SS, Dumas E, Vulesevic B, Neagoe PE, White M, Sirois MG.

(12) Recombinant Human Vimentin Binds to P-Selectin and Blocks Neutrophil Capture and Rolling on Platelets and EndotheliumJournal of immunology (Baltimore, Md. : 1950)March 1, 2018Lam FW, Da Q, Guillory B, Cruz MA.

(13) Mapping cell surface adhesion by rotation tracking and adhesion footprintingScientific reportsMarch 14, 2017Li IT, Ha T, Chemla YR.supernatant. The beads were then incubated with 50 μL of 100 μg/mL PSGL-1-Fc Chimera (R&D systems, 3345-PS-050) for 2 hours on a rotator in room temperature before experiment. All beads were washed in PBS (pH 7.4)

(14) Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activityScientific reportsNovember 28, 2016Pepin M, Mezouar S, Pegon J, Muczynski V, Adam F, Bianchini EP, Bazaa A, Proulle V, Rupin A, Paysant J, et al.

(15) Single Neutralizing Monoclonal Antibodies Targeting the VP1 GH Loop of Enterovirus 71 Inhibit both Virus Attachment and Internalization during Viral EntryJournal of virologyDecember 1, 2015Ku Z, Ye X, Shi J, Wang X, Liu Q, Huang Z.1 ␮g of recombinant SCARB2-Fc (catalog number 1966-LM-050; R&D Systems), PSGL-1–Fc (catalog number 3345-PS-050; R&D Systems), or control human Fc (catalog number 10702-HNAH; Sino-Biotech) was mixed with 15 ␮l of

(16) TleA, a Tsh-like autotransporter identified in a human enterotoxigenic Escherichia coli strainInfection and immunityMay 1, 2015Gutiérrez D, Pardo M, Montero D, Oñate A, Farfán MJ, Ruiz-Pérez F, Del Canto F, Vidal R.

(17) Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rollingJournal of immunology (Baltimore, Md. : 1950)February 15, 2014Riese SB, Kuehne C, Tedder TF, Hallmann R, Hohenester E, Buscher K.

(18) Broad spectrum activity of a lectin-like bacterial serine protease family on human leukocytesPloS oneJanuary 1, 2014Ayala-Lujan JL, Vijayakumar V, Gong M, Smith R, Santiago AE, Ruiz-Perez F.

(19) Bromelain decreases neutrophil interactions with P-selectin, but not E-selectin, in vitro by proteolytic cleavage of P-selectin glycoprotein ligand-1PloS oneJanuary 1, 2013Banks JM, Herman CT, Bailey RC.

(20) Regulation of leukocyte recruitment by the long pentraxin PTX3Nature immunologyApril 1, 2010Deban L, Russo RC, Sironi M, Moalli F, Scanziani M, Zambelli V, Cuccovillo I, Bastone A, Gobbi M, Valentino S, et al.

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PSGL-1/CD162 Fc Chimera Protein

PSGL-1/CD162 Fc Chimera Protein

PSGL-1/CD162 Fc Chimera Protein

Recombinant Human PSGL-1/CD162 Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human PSGL-1/CD162 Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

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