Recombinant Human Dkk-3 Protein, CF 1118-DK-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Dkk-3 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $408.00Supplier Page View Company Product Page
Catalog Number1118-DK-050
FormatLyophilized from a 0.2 µm filtered solution in PBS
Size50 ug
Molecule NameDkk-3
NCBI Full Gene Namedickkopf WNT signaling pathway inhibitor 3
NCBI Gene AliasesCRRL, RIG, REIC
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 64-74 kDa, reducing conditions
Theoretical: 37.5 kDa
Source/Expression SystemNS0-derived Recombinant Human Dkk-3 Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
Conjugate/TagUnconjugated
ApplicationsBioactivity
SpeciesHuman

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site regionNature communicationsMay 22, 2024Li Y, Wei Y, Ultsch M, Li W, Tang W, Tombling B, Gao X, Dimitrova Y, Gampe C, Fuhrmann J, et al.

(2) Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse modeleLifeJanuary 29, 2024Martin Flores N, Podpolny M, McLeod F, Workman I, Crawford K, Ivanov D, Leonenko G, Escott-Price V, Salinas PC.

(3) Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identityCell stem cellSeptember 7, 2023Ruscitto A, Chen P, Tosa I, Wang Z, Zhou G, Safina I, Wei R, Morel MM, Koch A, Forman M, et al.

(4) A WNT4- and DKK3-driven canonical to noncanonical Wnt signaling switch controls multiciliogenesisJournal of cell scienceAugust 15, 2023Cooney RA, Saal ML, Geraci KP, Maynard C, Cleaver O, Hoang ON, Moore TT, Hwang RF, Axelrod JD, Vladar EK.

(5) Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degenerationNature communicationsSeptember 5, 2022Gerhardy S, Ultsch M, Tang W, Green E, Holden JK, Li W, Estevez A, Arthur C, Tom I, Rohou A, et al.

(6) NOTUM from Apc-mutant cells biases clonal competition to initiate cancerNatureJune 1, 2021Flanagan DJ, Pentinmikko N, Luopajärvi K, Willis NJ, Gilroy K, Raven AP, Mcgarry L, Englund JI, Webb AT, Scharaw S, et al.R&D Systems, #9150-NO-050), WIF1 (1 μg/ml; R&D Systems, #135-CW-050) and DKK3 (1 μg/ml; R&D Systems, #1118-DK-050) was mixed with standard growth medium and replenished every other day. For organoid growth rate experiments,

(7) Combined Serum DKK3 and Circulating CD133 Cells as Prognostic Biomarkers for Ovarian Cancer PatientsOncoTargets and therapyJanuary 1, 2021Nie XC, He F, Lan C, Niu JM, Xia P.

(8) Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophyProceedings of the National Academy of Sciences of the United States of AmericaMay 5, 2020Tom I, Pham VC, Katschke KJ Jr, Li W, Liang WC, Gutierrez J, Ah Young A, Figueroa I, Eshghi ST, Lee CV, et al.

(9) A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesisBMC cancerMarch 1, 2017Cheng JY, Brown TC, Murtha TD, Stenman A, Juhlin CC, Larsson C, Healy JM, Prasad ML, Knoefel WT, Krieg A, et al.

(10) Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-SeqPloS oneJanuary 1, 2016Marthandan S, Baumgart M, Priebe S, Groth M, Schaer J, Kaether C, Guthke R, Cellerino A, Platzer M, Diekmann S, et al.was replenished every 2 days. A similar procedure was undertaken in HFF strains (PD = 22) with rDKK3 (1118-DK-050; R&D SYSTEMS) for a range of concentrations (0, 0.1, 1, 10, 50 μg/ml). The samples were analyzed at

(11) Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during agingThe Journal of clinical investigationJuly 1, 2014Zhu Y, Demidov ON, Goh AM, Virshup DM, Lane DP, Bulavin DV.

(12) Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitorsNatureJuly 26, 2012Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, et al.

(13) Molecular architecture of the DNA replication origin activation checkpointThe EMBO journalOctober 6, 2010Tudzarova S, Trotter MW, Wollenschlaeger A, Mulvey C, Godovac-Zimmermann J, Williams GH, Stoeber K.Immunodetection of Dkk3 was blocked by preincubation of Dkk3 antibody with recombinant human Dkk3 (1118-DK-050; R&D Systems Europe, Abingdon, UK) (1:1 w/w). N-glycanase digestion Cytoplasmatic protein fractions

(14) The Dickkopf-homolog 3 is expressed in tumor endothelial cells and supports capillary formationInternational journal of cancerApril 1, 2008Untergasser G, Steurer M, Zimmermann M, Hermann M, Kern J, Amberger A, Gastl G, Gunsilius E.

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Recombinant Human Dkk-3 Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human Dkk-3 Protein, CF from R&D Systems, a Bio-Techne Brand

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