Sonic Hedgehog/Shh (C25II), N-Terminus Protein 464-SH-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemSonic Hedgehog/Shh (C25II), N-Terminus Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $398.00Supplier Page View Company Product Page
Catalog Number464-SH-025
SpeciesMouse
Size25 ug (also 200 ug, 1 mg)
Molecule NameSonic Hedgehog/Shh
NCBI Full Gene Namesonic hedgehog signaling molecule, sonic hedgehog
NCBI Gene AliasesHPE3, Hhg1, Hx, Dsh, SMMCI, M100081, Hxl3, HHG1, TPT, HLP3, TPTPS, ShhNC, MCOPCB5, 9530036O11Rik
FormatLyophilized from a 0.2 µm filtered solution in NaH2PO4, NaCl and DTT with BSA as a carrier protein
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular Weight19.8 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Mouse Sonic Hedgehog/Shh (C25II) N-Terminus
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 25 ug (also 200 ug, 1 mg)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Interregional human assembloids recapitulate fetal brain morphologies and enhance neuronal complexitybioRxiv : the preprint server for biologyOctober 24, 2025Antunes ASLM, Athié MCP, Silveira ACC, Renner J, Dias EV, Dos Santos JVR, Hrvoj-Mihic B, Canateli C, Meidanis J, Muotri AR, et al.

(2) The ciliary kinesin KIF7 controls the development of the cerebral cortex by acting differentially on SHH signaling in dorsal and ventral forebrainElifeSeptember 16, 2025María Pedraza, Valentina Grampa, Sophie Scotto-Lomassese, Julien Puech, Aude Muzerelle, Azka Mohammad, Sophie Lebon, Nicolas Renier, Christine Metin, Justine Massonfor time-lapse imaging. Pharmacological treatment Either recombinant Mouse SHH (C25II), N-terminus (464-SH-025, R&D Systems) at 0.5 µg/ml final or cyclopamine (C4116, Sigma) at 2.5 µM final were added to the culture

(3) The ciliary kinesin KIF7 controls the development of the cerebral cortex by acting differentially on SHH signaling in dorsal and ventral forebraineLifeSeptember 16, 2025María Pedraza, Valentina Grampa, Sophie Scotto-Lomassese, Julien Puech, Aude Muzerelle, Azka Mohammad, Sophie Lebon, Nicolas Renier, Christine Metin, Justine Massonfor time-lapse imaging. Pharmacological treatment Either recombinant Mouse SHH (C25II), N-terminus (464-SH-025, R&D Systems) at 0.5 µg/ml final or cyclopamine (C4116, Sigma) at 2.5 µM final were added to the culture

(4) Brain organoid maturation and implantation integration based on electrical signals inputJournal of advanced researchJuly 1, 2025Li XH, Hu N, Chang ZH, Shi JX, Fan X, Chen MM, Bao SQ, Chen C, Zuo JC, Zhang XW, et al.

(5) Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALSNature communicationsMay 19, 2025Schweingruber C, Nijssen J, Mechtersheimer J, Reber S, Lebœuf M, O''Brien NL, Mei I, Hedges E, Keuper M, Benitez JA, et al.d1-2 (200 nM LDN193189 [Tocris, 6053], 10 µM SB431542 [Tocris, 1614], 25 ng/mL SHH-C25II [R&D Systems, 464-SH-025], 250 nM Purmorphamine [Tocris, 4551], 1 µM retinoic acid [Sigma-Aldrich, R2625]), followed by seven

(6) Enhanced yield and subtype identity of hPSC-derived midbrain dopamine neuron by modulation of WNT and FGF18 signalingbioRxiv : the preprint server for biologyJanuary 6, 2025Kim TW, Piao J, Bocchi VD, Koo SY, Choi SJ, Chaudhry F, Yang D, Cho HS, Hergenreder E, Perera LR, et al.

(7) Huntington's disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoidsNature communicationsAugust 2, 2024Galimberti M, Nucera MR, Bocchi VD, Conforti P, Vezzoli E, Cereda M, Maffezzini C, Iennaco R, Scolz A, Falqui A, et al.

(8) Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegenerationCell stem cellAugust 1, 2024Saurat N, Minotti AP, Rahman MT, Sikder T, Zhang C, Cornacchia D, Jungverdorben J, Ciceri G, Betel D, Studer L.

(9) Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neuronsProceedings of the National Academy of Sciences of the United States of AmericaApril 23, 2024Mohd Rafiq N, Fujise K, Rosenfeld MS, Xu P, De Camilli P.

(10) Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neuronsNeural regeneration researchApril 1, 2024Chen Y, Kuang J, Niu Y, Zhu H, Chen X, So KF, Xu A, Shi L.dissociated and cultured in N2B27 medium with SHH (100 ng/mL, R&D System, Minneapolis, MN, USA, Cat# 464-SH-025) and FGF8 (100 ng/mL, R&D System, Cat# 423-F8-025). Next, NPC were cultured according to the optimized

(11) iSCORE-PD: an isogenic stem cell collection to research Parkinson's DiseasebioRxiv : the preprint server for biologyFebruary 13, 2024Busquets O, Li H, Mohieddin Syed K, Jerez PA, Dunnack J, Bu RL, Verma Y, Pangilinan GR, Martin A, Straub J, et al.

(12) Organoids from mouse molar and incisor as new tools to study tooth-specific biology and developmentStem cell reportsMay 9, 2023Hermans F, Hemeryck L, Bueds C, Torres Pereiro M, Hasevoets S, Kobayashi H, Lambrechts D, Lambrichts I, Bronckaers A, Vankelecom H.

(13) hPSC-derived sacral neural crest enables rescue in a severe model of Hirschsprung's diseaseCell stem cellMarch 2, 2023Fan Y, Hackland J, Baggiolini A, Hung LY, Zhao H, Zumbo P, Oberst P, Minotti AP, Hergenreder E, Najjar S, et al.

(14) Parallel Neurodegenerative Phenotypes in Sporadic Parkinson's Disease Fibroblasts and Midbrain Dopamine NeuronsbioRxiv : the preprint server for biologyFebruary 12, 2023Corenblum MJ, McRobbie-Johnson A, Carruth E, Bernard K, Luo M, Mandarino LJ, Peterson S, Billheimer D, Maley T, Eggers ED, et al.

(15) Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activationCell death & diseaseJanuary 21, 2023Wu PR, Chiang SY, Midence R, Kao WC, Lai CL, Cheng IC, Chou SJ, Chen CC, Huang CY, Chen RH.

(16) Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomerseLifeJanuary 10, 2023Wu S, Hernandez Villegas NC, Sirkis DW, Thomas-Wright I, Wade-Martins R, Schekman R.

(17) Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplicationsCell death & diseaseOctober 19, 2022Iannielli A, Luoni M, Giannelli SG, Ferese R, Ordazzo G, Fossati M, Raimondi A, Opazo F, Corti O, Prehn JHM, et al.

(18) A combined cell and gene therapy approach for homotopic reconstruction of midbrain dopamine pathways using human pluripotent stem cellsCell stem cellMarch 3, 2022Moriarty N, Gantner CW, Hunt CPJ, Ermine CM, Frausin S, Viventi S, Ovchinnikov DA, Kirik D, Parish CL, Thompson LH.

(19) Hedgehog signaling is controlled by Rac1 activityTheranosticsJanuary 1, 2022Tang C, Wu X, Ren Q, Yao M, Xu S, Yan Z.

(20) Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neuronsScientific reportsNovember 15, 2021Earley AM, Burbulla LF, Krainc D, Awatramani R.

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Sonic Hedgehog/Shh (C25II), N-Terminus Protein

Sonic Hedgehog/Shh (C25II), N-Terminus Protein

Sonic Hedgehog/Shh (C25II), N-Terminus Protein

Sonic Hedgehog/Shh (C25II), N-Terminus Protein

Sonic Hedgehog/Shh (C25II), N-Terminus Protein

Sonic Hedgehog/Shh (C25II), N-Terminus Protein from R&D Systems, a Bio-Techne Brand

Description

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (79)

Reviews

Sonic Hedgehog/Shh (C25II), N-Terminus Protein from R&D Systems, a Bio-Techne Brand

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