COX-2 (human, recombinant) 60122 from Cayman Chemical

Product Specs
ItemCOX-2 (human, recombinant)
CompanyCayman Chemical
Price $908.00Supplier Page View Company Product Page
Catalog Number60122
Size5 kU
ActivitySpecific activity: 8,000 units/mg
Specieshuman
NCBI Full Gene Nameprostaglandin-endoperoxide synthase 2
NCBI Gene AliasesCOX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
Research AreaCyclooxygenase Pathway, Immunology & Inflammation, Inflammatory Lipid Mediators, Lipid Biochemistry, Prostaglandins
Format80 mM Tris, pH 8.0, with 0.3 mM DDC, 0.01% Tween 20, and 10% glycerol
Molecular Weight67.9 kDa
Purity≥75% (estimated by SDS-PAGE)
Source/Expression SystemActive recombinant N-terminal His-tagged COX-2N580A mutant purified from insect cells
Storage-80
OriginUSA

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Research on Application of Japanese Quince (Chaenomeles L.) and Pork Collagen in Dark Chocolate—Benefits in Prevention of Inflammation In Vitro ModelNutrientsJune 4, 2024Szymon Byczkiewicz, Dominik Szwajgier, Ewa Baranowska-Wójcik, Aleksandra Telichowska, Krystyna Szymandera-Buszka, Janusz Wojtczak, Joanna Kobus-CisowskaAAPH was obtained from Acros Organics, Ottawa, ON, Canada (401560250), while COX-2 (human recombinant, 60122) and COX-2 activity assay kit (760151) were acquired from Cayman, Ann Arbor, MI, USA. Buffer salts,

(2) Identification of potential anti-inflammatory components in Moutan Cortex by bio-affinity ultrafiltration coupled with ultra-performance liquid chromatography mass spectrometryFrontiers in PharmacologyFebruary 7, 2024Caomin Zou, Qianru Chen, Jiasheng Li, Xiguang Lin, Xingyang Xue, Xinhang Cai, Yicheng Chen, Yue Sun, Shumei Wang, Ying Zhang, et al.Inhibitor Screening Kits were procured from Beyotime Biotechnology (Shanghai, China). Human recombinant COX-2 (No.60122, 5000U) was obtained from Cayman Chemicals (Ann Arbor, MI, United States). Lipopolysaccharides (LPS,

(3) Is Caperatic Acid the Only Compound Responsible for Activity of Lichen Platismatia glauca within the Nervous System?Antioxidants (Basel)October 20, 2022ElÅ¼bieta StudziÅ„ska-Sroka, Aleksandra Majchrzak-CeliÅ„ska, Monika BaÅ„durska, Natalia Rosiak, Dominik Szwajgier, Ewa Baranowska-WÃ³jcik, Marcin SzymaÅ„ski, Wojciech Gruszka, Judyta Cielecka-Piontekstrictly as suggested by the producer and were combined with COX-2 enzyme (Human recombinant, Cayman No. 60122, pre- diluted 100-fold using 100 mM, pH 8.0 Tris buffer). A volume of 40.0 μL of studied sample was

(4) Lichen-Derived Compounds and Extracts as Biologically Active Substances with Anticancer and Neuroprotective PropertiesPharmaceuticals (Basel)December 10, 2021Elżbieta Studzińska-Sroka, Aleksandra Majchrzak-Celińska, Przemysław Zalewski, Dominik Szwajgier, Ewa Baranowska-Wójcik, Barbara Kaproń, Tomasz Plech, Marcin Żarowski, Judyta Cielecka-Piontekstrictly as suggested by the producer and were combined with COX-2 enzyme (Human recombinant, Cayman No. 60122, pre-diluted 100-fold using 100 mM, pH 8.0 Tris buffer). A volume of 0.01 mL of the studied sample,

(5) Blackberry Leaves as New Functional Food? Screening Antioxidant, Anti-Inflammatory and Microbiological Activities in Correlation with Phytochemical AnalysisAntioxidants (Basel)December 4, 2021Magdalena Paczkowska-Walendowska, Anna Gościniak, Daria Szymanowska, Dominik Szwajgier, Ewa Baranowska-Wójcik, Piotr Szulc, Dagna Dreczka, Marek Simon, Judyta Cielecka-Piontek(AAPH) was from Acros Organics (Poznan, Poland) (401560250), cyclooxygenase-2 (COX-2, human recombinant, 60122) and COX-2 activity assay kit (760151) were from Cayman Chemicals (Ann Arbor, Michigan, USA). Buffer

(6) Cyclodextrin as Functional Carrier in Development of Mucoadhesive Tablets Containing Polygoni cuspidati Extract with Potential for Dental ApplicationsPharmaceuticsNovember 12, 2021Magdalena Paczkowska-Walendowska, Emilia Szymańska, Katarzyna Winnicka, Dominik Szwajgier, Ewa Baranowska-Wójcik, Marek A. Ruchała, Marek Simon, Judyta Cielecka-Piontekdihydrochloride (AAPH) was from Acros Organics (401560250), cyclooxygenase-2 (COX-2, human recombinant, 60122) and COX-2 activity assay kit (760151) were from Cayman Chemicals (Ann Arbor, MI, USA). Buffer salts,

(7) Is Phytomelatonin Complex Better Than Synthetic Melatonin? The Assessment of the Antiradical and Anti-Inflammatory PropertiesMoleculesOctober 8, 2021Wirginia Kukula-Koch, Dominik Szwajgier, Katarzyna Gaweł-Bęben, Marcelina Strzępek-Gomółka, Kazimierz Głowniak, Henry O. MeissnerCOX Activity Assay Kit (No. 760151) were used together with the COX-2 enzyme (Human recombinant, Cayman No. 60122). 4.4. The HPLC-ESI-Q-TOF-MS-Based Study on the Composition and Quantity of MLT in the Tested Samples An

(8) Design, synthesis and in vitro and in vivo biological evaluation of flurbiprofen amides as new fatty acid amide hydrolase/cyclooxygenase-2 dual inhibitory potential analgesic agentsJournal of Enzyme Inhibition and Medicinal ChemistryApril 26, 2021Alessandro Deplano, Jessica Karlsson, Federica Moraca, Mona Svensson, Claudia Cristiano, Carmine Marco Morgillo, Christopher J. Fowler, Roberto Russo, Bruno Catalanotti, Valentina OnnisRadiolabeled Chemicals, Inc (St.Louis, MO). Ovine COX-1 (cat. no. 60100), human recombinant COX-2 (cat. no. 60122), COX-2 polyclonal antibody (rabbit antimouse, cat #: 160106), arachidonic acid, 2-AG, AEA and URB597

(9) Permeability of Hypogymnia physodes Extract Component—Physodic Acid through the Blood–Brain Barrier as an Important Argument for Its Anticancer and Neuroprotective Activity within the Central Nervous SystemCancers (Basel)April 5, 2021Elżbieta Studzińska-Sroka, Aleksandra Majchrzak-Celińska, Przemysław Zalewski, Dominik Szwajgier, Ewa Baranowska-Wójcik, Marcin Żarowski, Tomasz Plech, Judyta Cielecka-Piontekprepared as suggested by the producer and combined with COX-2 enzyme (Human recombinant, Cayman No. 60122, pre-diluted 100-fold using 100 mM, pH 8.0 Tris buffer). A volume of 0.01 mL of a diluted sample was

(10) S-nitrosylated and non-nitrosylated COX2 have differential expression and distinct subcellular localization in normal and breast cancer tissueNPJ breast cancerNovember 24, 2020Jindal S, Pennock ND, Klug A, Narasimhan J, Calhoun A, Roberts MR, Tamimi RM, Eliassen AH, Weinmann S, Borges VF, et al.sites. Immunoblotting Recombinant human COX1 protein (Abcam, Ab-198643, 4 ng), human COX2 protein (Cayman Chemical, 60122, 4 ng), and 25 µg cell line lysates in RIPA buffer were separated by WES automated gel electrophoresis

(11) The fatty acid amide hydrolase and cyclooxygenase-inhibitory properties of novel amide derivatives of carprofenBioorganic ChemistryAugust 1, 2020Alessandro Deplano, Jessica Karlsson, Christopher J. Fowler, Valentina OnnisRadiolabeled Chemicals, Inc (St. Louis, MO). Ovine COX-1 (cat. no. 60100), human recombinant COX-2 (cat. no. 60122), non-radioactive AEA, arachidonic acid (AA) and 2-AG were purchased from the Cayman Chemical Co. (Ann

(12) N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's diseaseNature communicationsMay 12, 2020Lee JY, Han SH, Park MH, Song IS, Choi MK, Yu E, Park CM, Kim HJ, Kim SH, Schuchman EH, et al.modifications11. To confirm the SphK1-mediated COX2 acetylation, 10 μg COX2 (LSBio, LS-G21094 and Cayman, 60122) was incubated with [14C] acetyl-CoA (2 μCi, Perkin-Elmer, NEC313050UC) and SphK1 (WT or mutants) in

(13) Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofenJournal of Enzyme Inhibition and Medicinal ChemistryMarch 24, 2020Alessandro Deplano, Jessica Karlsson, Mona Svensson, Federica Moraca, Bruno Catalanotti, Christopher J. Fowler, Valentina Onnis(St. Louis, MO). Non-radioactive AEA, ovine COX-1 (cat. no. 60100), human recombinant COX-2 (cat. no. 60122), arachidonic acid (AA) and 2-AG were purchased from the Cayman Chemical Co. (Ann Arbour, MI, USA).

(14) Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase InhibitorPLOS ONESeptember 25, 2015Sandra Gouveia-Figueira, Jessica Karlsson, Alessandro Deplano, Sanaz Hashemian, Mona Svensson, Marcus Fredriksson Sundbom, Cenzo Congiu, Valentina Onnis, Christopher J. FowlerSanta Cruz Biotechnology Inc. (Dallas, Texas, USA). Ovine COX-1 (cat. no. 60100), human recombinant COX-2 (cat. no. 60122), COX-2 polyclonal antibody (rabbit anti-mouse, cat #: 160106), arachidonic acid, 2-AG, AEA and URB597

(15) Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-OxygenaseChemical Biology & Drug DesignJuly 1, 2015Carolina Mascayano, Victoria Espinosa, Silvia Sepúlveda-Boza, Eric K. Hoobler, Steve Perry, Giovanni Diaz, Theodore R. Holmanabsorbance at 234 nm. COX-1 and COX-2 Inhibition Ovine COX-1 (cat. no. 60100) and human COX-2 (cat. no. 60122) were purchased from Cayman Chemical. Approximately 2 μg of either COX-1 or COX-2 was added to buffer

(16) Potent and Selective Inhibitors of Human Reticulocyte 12/15-Lipoxygenase as Anti-Stroke TherapiesJournal of Medicinal ChemistryMay 22, 2014Ganesha Rai et al.LC–MS/MS and were found to be >98% pure. Ovine COX-1 (catalog no. 60100) and human COX-2 (catalog no. 60122) were purchased from Cayman chemicals. All other chemicals were of high quality and used without further

(17) Inhibition of endocannabinoid metabolism by the metabolites of ibuprofen and flurbiprofenPloS oneJanuary 1, 2014Karlsson J, Fowler CJ.Radiolabeled Chemicals, Inc (St Louis, MO, USA). Ovine COX-1 (cat. no. 60100), human recombinant COX-2 (cat. no. 60122), arachidonic acid, 2-arachidonoylglycerol and non-radioactive anandamide were purchased from the Cayman Chemical

(18) Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal TherapyPLoS ONEJune 24, 2013Eric K. Hoobler et al.reported previously [34]. Cyclooxygenase assay Ovine COX-1 (Cat. No. 60100) and human COX-2 (Cat. No. 60122) were purchased from Cayman chemical. Approximately 2 µg of either COX-1 or COX-2 were added to buffer

(19) Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamideJournal of Enzyme Inhibition and Medicinal ChemistryFebruary 1, 2013Christopher J. Fowler, Emmelie Björklund, Aron H. Lichtman, Pattipati S. Naidu, Cenzo Congiu, Valentina OnnisRadiolabeled Chemicals, Inc (St. Louis, MO). Ovine COX-1 (cat. no. 60100), human recombinant COX-2 (cat. no. 60122), arachidonic acid and non-radioactive anandamide were obtained from the Cayman Chemical Co (Ann Arbor,

(20) Discovery of Potent and Selective Inhibitors of Human Platelet-Type 12- LipoxygenaseJournal of Medicinal ChemistryAugust 11, 2011Victor Kenyon et al.timeframe of the experiment. Cyclooxygenase Assay Ovine COX-1 (Cat. No. 60100) and human COX-2 (Cat. No. 60122) were purchased from Cayman chemical. Approximately 2 μg of either COX-1 or COX-2 were added to buffer containing

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COX-2 (human, recombinant)

COX-2 (human, recombinant)

COX-2 (human, recombinant) from Cayman Chemical

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Cayman Chemical

Citations (21)

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COX-2 (human, recombinant) from Cayman Chemical

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