Caspase Inhibitor Z-VAD-FMK, 20mM G7232 from Promega

Product Specs
ItemCaspase Inhibitor Z-VAD-FMK, 20mM
CompanyPromega
Price Supplier Page View Company Product Page
Catalog NumberG7232
Conjugate/TagUnconjugated
Size125microl
Molecule NameCaspase Inhibitor Z-VAD-FMK

Specifications/Features

Ki, IC, EC, or working concentration: Suggested concentration: 20µM.

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Promega

2800 Woods Hollow Rd

Madison, WI 53711

United States

Phone: Tel: +1 (608) 274-4330
Fax: +1 (608) 277-2516

Email: custserv@promega.com
techserv@promega.com

Company Profile

Website: http://www.promega.com

(1) Natural product target identification of wheldone, a fungal metabolite, as a KIF11 inhibitor in ovarian cancer using the DiffPOP (Differential Protein Precipitation) methodMolecular & Cellular ProteomicsMarch 23, 2026Manead Khin, Alejandra Cavazos Saldana, Manuel Rangel-Grimaldo, Huzefa A. Raja, Daniel Abegg, Julia Ekiert, Chang Liu, Sweta Misra, Kiira Ratia, Alexander Adibekian, et al.allowed to attach overnight. Compounds, staurosporine (Selleckchem, #S1421), and ZVAD-FMK (Promega, #G7231) suspended in DMSO were diluted to final concentrations and added to the cells. The final vehicle concentration

(2) RIPK1 regulates β-cell fate via actions on gene expression and kinase signaling in a mouse model of β-cell self-reactivityCell Death & DiseaseFebruary 12, 2026Christopher J. Contreras, Noyonika Mukherjee, Arianna Harris-Kawano, Egan G. Mather, Nansalmaa Amarsaikhan, Christopher Davis, Christine A. Berryhill, Madeline Peyton, Debjyoti Kundu, Kaitlyn A. Colglazier, et al.Shanghai, China), LD4172 [50] (100 nM, Dr. Jin Wang, Baylor College of Medicine), zVAD-FMK (50 μM, G7232, Promega, Madison, WI). Quantitative real time polymerase chain reaction (qPCR) Total RNA from was

(3) Modular inflammation network discovery from large-scale phenotypic screening in genetically heterogeneous mouse brainsJournal of neuroinflammationSeptember 29, 2025Xiong M, Miosge LA, Correa-Ospina C, Yan CMY, Cripps T, Bauernfried S, Wang Y, Crow M, Morris LX, Andrews TD, et al.µg/mL doxycycline (Clontech Cat# 631311) for 18 h in the presence of 20 µM Z-VAD-FMK (Promega Cat# G7232) or were left untreated in the presence of 20 µM Z-VAD-FMK. 18 h after induction, cells were lysed in

(4) A non-apoptotic caspase-8–meteorin pathway in hepatocytes promotes MASH fibrosisNature MetabolismSeptember 26, 2025Xiaobo Wang, Mary P. Moore, Hongxue Shi, Yang Xiao, Jiayu Zhang, Lanuza A. P. Faccioli, Zhiping Hu, Shareef Khalid, Danish Saleheen, Dwayne G. Stupack, et al.(105534-AAV8) from Addgene; mouse Metrn plasmid (no. 215466) from Origene; caspase inhibitor Z-VAD-FMK (G7231) from Promega; caspase-8 inhibitor Z-IETD-FMK (FMK007) from R&D Systems; human METRN recombinant protein

(5) EXPRESS: RIPK3 regulates microglial polarization through the TLR4/MyD88 pathway in neuropathic painMolecular PainSeptember 1, 2025Sihan E, Qingbiao Song, Zhaokun Zhang, Yingxia Digestion Liangof the required place in TNF-a (50 ng/ml, mice: CYT-252, Prospec, Rehovot, Israel) and Z-VAD (30 mM, G7232, Promega, Madison, WI) was co-induced for 24 h to establish an in vitro cellular necroptosis model.

(6) Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck CancerCancer ResearchAugust 15, 2025Keiichi Koshizuka, Xingyu Wu, Kuniaki Sato, Pham Thuy Tien Vo, Gosia M. Murawska, Tomohiko Ishikawa, Zhiyong Wang, Alfredo A. Molinolo, Edward A. Dennis, Cherie-Ann O. Nathan, et al.Hydroxychloroquine sulfate (H0915), and Auranofin (A6733) was purchased from Sigma-Aldrich. Z-VAD (G7231) was purchased from Promega. RSL3 (S8155), Erastin (S7242), Ferrostatin-1 (S7243), Necrostatin-1 (S8037)

(7) Integrating Single-Cell and Experimental Analyses Uncover Macrophage Ferroptosis Is a Key Event in the Development of Chronic Obstructive Pulmonary DiseaseFASEB JJune 30, 2025Xiaomei Duan, Tingting Hu, Ehbal Tuyghun, Zheng Li, Jing Jing, Dan Xu, Lijuan Xu, Jianbing Ding, Fengsen Li, Min Jiang, et al.(D3861, Invitrogen), necrostatin‐1 (N9037, Sigma‐Aldrich), ferroOrange (F374, Dojindo), and z‐VAD‐fmk (G7231, Promega) were used as reagents. 2.4 Cell Culture The Cell Bank of the Chinese Academy of Sciences

(8) TFEB Orchestrates Stress Recovery and Paves the Way for Senescence Induction in Human Dermal FibroblastsAging CellMay 1, 2025Lena Guerrero‐Navarro, Pablo Monfort‐Lanzas, Vinzenz Krichbaumer, Mariana E. G. De Araújo, Jlenia Monfregola, Lukas A. Huber, Andrea Ballabio, Pidder Jansen‐Dürr, Maria Cavinatotreatment, cells were treated with a 20 μM concentration of the Pan‐caspase inhibitor Z‐VAD‐FMK (Promega, G7231), continuing until day 4, when the assessment of cell death rates was conducted. 4.11 RNA‐Seq Analysis RNA

(9) The EMCV protein 2B* is required for efficient cell lysis via both caspase-3-dependent and -independent pathways during infectionJ Gen VirolFebruary 10, 2025Samantha K. Nguyen, Edward Long, James R. Edgar, Andrew E. Firth, Hazel Stewartfinal concentration and source were as follows: STS, 1 µM (Abcam, AB146588); z-VAD-fmk, 50 µM (Promega, G7231); 2-BP, 100 µM (Sigma, 238422); and z-VEID-fmk, 40 µM (Sigma, 218757). Flow cytometry BHK-21 cells

(10) Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars FloppyProceedings of the National Academy of SciencesJune 18, 2024Alfa Herrera, Megan M. Packer, Monica Rosas-Lemus, George Minasov, Jiexi Chen, John H. Brumell, Karla J. F. Satchellactivation, media was exchanged 4 h posttransfection, cells were treated with 5 μM Z-VAD-FMK (Promega G7231) or DMSO vehicle control, and were incubated another 14 h. Following transfection, cells were collected,

(11) Oxidative photocatalysis on membranes triggers non-canonical pyroptosisNature communicationsMay 13, 2024Lee C, Park M, Wijesinghe WCB, Na S, Lee CG, Hwang E, Yoon G, Lee JK, Roh DH, Kwon YH, et al.HeLa cells were grown with Liproxstatin-1 (10 µM) (Sigma Aldrich SML1414, USA) and z-VAD-fmk (4 µM) (Promega G7231, USA) for 16 h. BTP was then added to the cells (8 µM), followed by incubation for 2 h. After replacing

(12) Investigation of Staphylococcus aureus Biofilm-Associated Toxin as a Potential Squamous Cell Carcinoma TherapeuticMicroorganismsJanuary 30, 2024Zi Xin Ong, Bavani Kannan, Anthony R. J. Phillips, David L. BeckerSigma Aldrich, Burlington, MA, USA), Nec-1 (N9037, Sigma Aldrich, Burlington, MA, USA), and Z-VAD-FMK (G7231, Promega, Madison, WI, USA), and Hla-neutralising anti-staphylococcal α-toxin rabbit whole anti-serum

(13) Production of marmoset eggs and embryos from xenotransplanted ovary tissuesScientific ReportsOctober 24, 2023Runa Hirayama, Hiroaki Taketsuru, Ena Nakatsukasa, Rie Natsume, Nae Saito, Shuko Adachi, Sayaka Kuwabara, Jun Miyamoto, Shiori Miura, Nobuyoshi Fujisawa, et al.days after the storage. For ovarian protection experiments, Z-VAD-FMK (Caspase Inhibitor Z-VAD-FMK; G7231, Promega, USA) was added to Lifor (final concentration: 50 µM). Marmoset ovaries Marmoset (n = 135)

(14) Altered connectomes of adult-born granule cells following engraftment of GABAergic progenitors in the mouse hippocampusProgress in NeurobiologyJuly 1, 2023Muhammad N. Arshad, Alejandro Pinto, Henriette van Praag, Janice R. Naegelegrowth factor,Sigma,F0291, Epidermal growth factor,Invitrogen,53303–018, Caspase Inhibitor,Promega,G7231, B27,Gibco,17504–044, HBSS powder,Sigma,H4891-10X1L, 2.5% Trypsin (10X),Gibco,15090–046, Trypsin

(15) Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars FloppybioRxiv : the preprint server for biologyMay 12, 2023Herrera A, Packer MM, Rosas-Lemus M, Minasov G, Brummel JH, Satchell KJF.activation, media was exchanged four hours post-transfection, cells were treated with 5 μM Z-VAD-FMK (Promega G7231) or DMSO vehicle control, and were incubated another 14 hours. Following transfection, cells were collected,

(16) Multiple sclerosis plasma IgG aggregates induce complement-dependent neuronal apoptosisCell death & diseaseApril 8, 2023Zhou W, Graner M, Paucek P, Beseler C, Boisen M, Bubak A, Asturias F, George W, Graner A, Ormond D, et al.tested MS drug Mitoxantrone (Cayman Chemical #14842) and pan-caspase inhibitor Z-VAD-FMK (Promega #G7231). Comparison of cytotoxicity by plasma and paired CSF A-FT Various amounts of plasma A-FT (0, 2, 4,

(17) SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1Cell death and differentiationFebruary 1, 2023Wang D, Liang W, Huo D, Wang H, Wang Y, Cong C, Zhang C, Yan S, Gao M, Su X, et al.reagents diluted according to the manufacturer’s instructions were as follows: z-VAD-fmk (Zvad, Promega, G7231), Necrostatin-1 (Nec-1, Sigma-Aldrich, N9037), Deferoxamine (DFO, Sigma-Aldrich, D9533), Ferrostatin-1

(18) Hippocampal transplants of fetal GABAergic progenitors regulate adult neurogenesis in mice with temporal lobe epilepsyNeurobiology of diseaseNovember 1, 2022Arshad MN, Oppenheimer S, Jeong J, Buyukdemirtas B, Naegele JR.transplantation media (Leibovitz’s L-15 (Gibco, 11415–064), supplemented with caspase inhibitor (Promega G7231), B27 (Gibco, 17504–044), fibroblast growth factor (Sigma, F0291), and epidermal growth factor (Invitrogen,

(19) RIPK1 and RIPK3 regulate TNFα-induced β-cell death in concert with caspase activityMolecular metabolismNovember 1, 2022Contreras CJ, Mukherjee N, Branco RCS, Lin L, Hogan MF, Cai EP, Oberst AA, Kahn SE, Templin AT.prior to analysis. The following reagents were used during cell culture treatment: zVAD-fmk (50 μM, G7232, Promega, Madison, WI), TNFα (40 ng/ml, mouse: CYT-252, Prospec, Rehovot, Israel), BV6 (5 μM, HY-16701,

(20) Kynurenine importation by SLC7A11 propagates anti-ferroptotic signalingMolecular cellMarch 3, 2022Fiore A, Zeitler L, Russier M, Groß A, Hiller MK, Parker JL, Stier L, Köcher T, Newstead S, Murray PJ.3R)-RSL3",Selleckchem,S8155 Ferrostatin-1,Sigma-Aldrich,SML0583 GCN2-IN-6,MedChemExpress,HY-130240 N-acetylcysteine (NAC),Sigma-Aldrich,A9165 Z-VAD-FMK,Promega,G7231 Liproxtatin,Selleckchem,S7699 Necrostatin1S,Cell Signaling Technology,17802 Buthionine sulfoximine

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Caspase Inhibitor Z-VAD-FMK, 20mM

Caspase Inhibitor Z-VAD-FMK, 20mM from Promega

Description

Specifications/Features

Promega

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Caspase Inhibitor Z-VAD-FMK, 20mM from Promega

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