Recombinant Human CD40 Ligand/TNFSF5 (aa 108-261) Protein 6245-CL-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human CD40 Ligand/TNFSF5 (aa 108-261) Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $424.00Supplier Page View Company Product Page
Catalog Number6245-CL-050
Size50 ug (also 1 mg)
ApplicationsBioactivity
FormatLyophilized from a 0.2 µm filtered solution in Tris-HCL, NaCl and EDTA with BSA as a carrier protein
Purity>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 18 kDa, reducing conditions
Theoretical: 16.9 kDa (monomer)
Conjugate/TagUnconjugated
SpeciesHuman
Source/Expression SystemE. coli-derived Recombinant Human CD40 Ligand/TNFSF5 (aa 108-261) Protein
Molecule NameCD40 Ligand/TNFSF5
NCBI Full Gene NameCD40 ligand
NCBI Gene AliasesIMD3, HIGM1, gp39, CD40L, CD154, TNFSF5, hCD40L, IGM, T-BAM, TRAP
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 3 months, 2 to 8 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) B lymphocyte responses in Parkinson’s disease and their possible significance in disease progressionBrain CommunicationsMarch 9, 2023Kirsten M Scott, Yen Ting Chong, Seoyoung Park, Ruwani S Wijeyekoon, Shaista Hayat, Rebeccah J Mathews, Zachary Fitzpatrick, Pam Tyers, Georgia Wright, Jennifer Whitby, et al.CpG DNA (1:10 000) (Cambridge Bioscience #Hycult HC4039) and CD40 ligand (1:5000) (R and D systems, 6245-CL-050) or alpha-synuclein fibrils for 48 h. Five hours prior to removal from culture, phorbol 12-myristate

(2) B cell-intrinsic changes with age do not impact antibody-secreting cell formation but delay B cell participation in the germinal centre reactionAging cellSeptember 1, 2022Lee JL, Fra-Bido SC, Burton AR, Innocentin S, Hill DL, Linterman MA.

(3) Truncated-semaphorin3A is a potential regulatory molecule to restore immune homeostasis in immune-mediated diseasesFrontiers in pharmacologyJanuary 1, 2022Eiza N, Kessler O, Sabag A, Neufeld G, Jones EY, Vadasz Z.

(4) Regulation of B cell functions by S-nitrosoglutathione in the EAE modelRedox biologySeptember 1, 2021Kim J, Islam SMT, Qiao F, Singh AK, Khan M, Won J, Singh I.costimulated with recombinant BAFF (100 ng/ml; R&D# 2149 B F) and human CD40 ligand (hCD40L; R&D system # 6245-CL-050) for 48 h in the presence or absence of GSNO pretreatment (50μM/1hr). 2.7 Fluorescence flow cytometry Before

(5) A cytotoxic anti-IL-3Rα antibody targets key cells and cytokines implicated in systemic lupus erythematosusJCI insightMay 5, 2016Oon S, Huynh H, Tai TY, Ng M, Monaghan K, Biondo M, Vairo G, Maraskovsky E, Nash AD, Wicks IP, et al.CpG A/ODN 2216 (InvivoGen, catalog tlrl-2216), imiquimod, or 0.5 μg/ml CD40L (R&D Systems, catalog 6245-CL-050) was added for 6 days to stimulate plasmablast expansion. The percentage of viable (Sytox Blue–) naive

(6) Modular expression analysis reveals functional conservation between human Langerhans cells and mouse cross-priming dendritic cellsThe Journal of experimental medicineMay 4, 2015Artyomov MN, Munk A, Gorvel L, Korenfeld D, Cella M, Tung T, Klechevsky E.

(7) Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammationJournal of immunology (Baltimore, Md. : 1950)May 15, 2014Singh MV, Davidson DC, Jackson JW, Singh VB, Silva J, Ramirez SH, Maggirwar SB.

(8) IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentationJournal of immunology (Baltimore, Md. : 1950)March 15, 2014Morandi F, Di Carlo E, Ferrone S, Petretto A, Pistoia V, Airoldi I.

(9) IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generationPLoS biologyJanuary 1, 2012Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barré B, Audran M, Bouvard B, et al.

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CD40 Ligand/TNFSF5 aa 108-261 Protein

CD40 Ligand/TNFSF5 aa 108-261 Protein

CD40 Ligand/TNFSF5 aa 108-261 Protein

CD40 Ligand/TNFSF5 aa 108-261 Protein

Recombinant Human CD40 Ligand/TNFSF5 (aa 108-261) Protein from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human CD40 Ligand/TNFSF5 (aa 108-261) Protein from R&D Systems, a Bio-Techne Brand

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