Fig 1: Effects of cell–cell communication between clusters of macrophages and beta cells. (a, b) Cell–cell communication of clusters IM1 (a) and IM2 (b) with different beta cell clusters. (c, d) Quantification of STAT3 phosphorylation in MIN6 cells (c, n=4) and western blot of dispersed islets (d, n=2) 20 min after treatment with IL-15. Data in (c) are presented as mean±SEM. (e) ERK1/2 phosphorylation in MIN6 cells treated with MIF for 20 min (n=2). (f) Cell–cell communication between the IM1 and IM2 clusters. ADORA2B, adenosine A2B receptor; ADRB2, adrenoceptor β2; aXb2, integrin α-X β2 complex; C5AR1, complement C5a receptor 1; CCL4L2, C-C motif chemokine ligand 4 like 2; CCL18, C-C motif chemokine ligand 18; CCR1, C-C motif chemokine receptor 1; CRLF2, cytokine receptor like factor 2; disp., dispersed; ENTPD1, ectonucleoside triphosphate diphosphohydrolase 1; FAM3C, metabolism-regulating signalling molecule C; FFAR2, free fatty acid receptor 2; GRIN2C, glutamate ionotropic receptor NMDA type subunit 2c; ICAM1, intercellular adhesion molecule 1; JAG2, jagged canonical notch ligand 2; LAMP1, lysosomal associated membrane protein 1; LTB, lymphotoxin β; LTBR, lymphotoxin β receptor; MRC1, mannose receptor C-type 1; NOTCH1, neurogenic locus notch homolog protein 1; NRP1, neuropilin-1; phospho, phosphorylated; PROS1, protein S; RPS19, ribosomal protein S19; PTPRC, protein tyrosine phosphatase receptor type C; TSLPR, cytokine receptor like factor 2; VEGFA, vascular endothelial growth factor A