Recombinant Human Complement Component C5a Protein, CF 2037-C5-025/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Complement Component C5a Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $392.00Supplier Page View Company Product Page
Catalog Number2037-C5-025/CF
SpeciesHuman
Molecule NameComplement Component C5a
FormatLyophilized from a 0.2 µm filtered solution in PBS
Size25 ug
NCBI Full Gene Namecomplement C5
NCBI Gene AliasesECLZB, C5D, C5b, C5a, CPAMD4
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular Weight8.3 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human Complement Component C5a Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Urine proteins reveal distinct coagulation and complement cascades underlying acute versus chronic lupus nephritisJournal of Clinical InvestigationOctober 1, 2025Ting Zhang, Jessica Castillo, Anto Sam Crosslee Louis Sam Titus, Kamala Vanarsa, Vedant Sharma, Sohan Kureti, Ramesh Saxena, Chandra Mohanhours with either vehicle or 10 ng/mL C3a (R&D Systems 3677-C3-025) or 10 ng/mL of C5a (R&D Systems 2037-C5-025/CF). BMDMs were generated using the isolated BM from the femur of C57/B6 mice (Jax 000664) and cultured

(2) Group A Streptococcal asparagine metabolism regulates bacterial virulenceEMBO ReportsApril 14, 2025Abhinay Sharma, Aparna Anand, Miriam Ravins, Xiaolan Zhang, Nicola Horstmann, Samuel A Shelburne, Kevin S McIver, Emanuel HanskiBuffer,Bio-Rad Laboratories,Cat# 1610744 purified recombinant human complement component C5a,R & D Systems,Cat# 2037-C5-025/CF Tris-Glycine Running Buffer,"Bio-Rad, USA",Cat# 161-0772 ß-mercaptoethanol,Sigma-Aldrich,Cat# M6250 "SuperSepTM

(3) A selective C5a-derived peptidomimetic enhances IgG response following inactivated SARS-CoV-2 immunization and confers rapid disease resolution following murine coronavirus infectionFront ImmunolApril 4, 2025Andrew J. Neville, Mackenzie E. Conrin, Thomas T. Schulze, Paul H. DavisEP67 (50 µg/mL), recombinant human complement component C5a protein (100 ng/mL) (R&D Systems, cat# 2037-C5-025/CF), or lipopolysaccharide (LPS) (1 µg/mL) (Invitrogen, cat# 00-4976-93) and incubated for 16 hours. Each

(4) Interferons and Cytokines Induce Transcriptional Activation of the Long‐Interspersed Element‐1 in Myeloid Cells from Autoimmune PatientsEuropean Journal of ImmunologyMarch 11, 2025Ethan Le, Fatemeh Moadab, Xiaoxing Wang, Rayan Najjar, Sadie J. Van den Bogaerde, Alison Bays, John LaCava, Tomas Mustelin(Invivogen cat# tlrl-stfla), 100 ng/ml FSL-1 (Invivogen cat# tlrl-fsl), 100ng/ml C5a (R&D Systems cat# 2037C5025/CF), 5 μM NMDI-14 (MedChemExpress cat# HY-111374), 1 μM methotrexate (Millipore-Sigma cat# 454126), 5 μg/ml

(5) C3a Mediates Endothelial Barrier Disruption in Brain-Derived, but Not Retinal, Human Endothelial CellsInternational Journal of Molecular SciencesOctober 19, 2024Hannah Nora Wolf, Larissa Guempelein, Juliane Schikora, Diana PaulySystems, Minneapolis, MN, USA, #3677-C3-025) or recombinant C5a (R&D Systems, Minneapolis, MN, USA, #2037-C5-025/CF) treatment for 2 and 24 h. Both anaphylatoxins were diluted in the respective culture medium. Treatment

(6) The Group A Streptococcal Vaccine Candidate VAX-A1 Protects against Group B Streptococcus Infection via Cross-Reactive IgG Targeting Virulence Factor C5a PeptidaseVaccines (Basel)December 3, 2023Sinead McCabe, Elisabet Bjånes, Astrid Hendriks, Zhen Wang, Nina M. van Sorge, Lucy Pill-Pepe, Leslie Bautista, Ellen Chu, Jeroen D. C. Codée, Jeff Fairman, et al.peptidase activity was assessed by incubating bacterial strains with recombinant human C5a (R&D Systems, 2037-C5-025/CF). Stationary phase cultures of GBS and L. lactis were resuspended at 2 × 109 CFUs/mL and then incubated

(7) Neutrophil-activating therapy for the treatment of cancerCancer cellFebruary 13, 2023Linde IL, Prestwood TR, Qiu J, Pilarowski G, Linde MH, Zhang X, Shen L, Reticker-Flynn NE, Chiu DK, Sheu LY, et al.2150-C5-025/CF Recombinant human TNF,BioLegend,Cat# 570104 Recombinant human C5a,R&D Systems,Cat# 2037-C5-025/CF Cobra venom factor,Millipore Sigma,Cat# 233552-1MG SC57461A,Cayman Chemical,Cat# 10108 CP-105696,Millipore

(8) Exposure of the Basophilic Cell Line KU812 to Liposomes Reveals Activation Profiles Associated with Potential Anaphylactic Responses Linked to Physico-Chemical CharacteristicsPharmaceuticsNovember 15, 2022Plant-Hately AJ, Eryilmaz B, David CAW, Brain DE, Heaton BJ, Perrie Y, Liptrott NJ.

(9) Complement Is Required for Microbe-Driven Induction of Th17 and PeriodontitisJournal of immunology (Baltimore, Md. : 1950)October 1, 2022Wang H, Ideguchi H, Kajikawa T, Mastellos DC, Lambris JD, Hajishengallis G.presence or absence of different concentrations of recombinant human C3a or C5a (cat# 3677-C3–025 or 2037-C5–025/CF, R&D Systems) or the synthetic microbial lipopeptide Pam3Cys (cat# tlrl-pms, InvivoGen, San Diego, CA).

(10) Different concentrations of C5a affect human dental pulp mesenchymal stem cells differentiationBMC oral healthSeptember 24, 2021Liu J, Wei X, Hu J, Tan X, Kang X, Gao L, Li N, Shi X, Yuan M, Hu W, et al.

(11) Extracellular Vesicles Derived from Endothelial Progenitor Cells Protect Human Glomerular Endothelial Cells and Podocytes from Complement- and Cytokine-Mediated InjuryCellsJuly 2, 2021Medica D, Franzin R, Stasi A, Castellano G, Migliori M, Panichi V, Figliolini F, Gesualdo L, Camussi G, Cantaluppi V.

(12) Transcriptional firing represses bactericidal activity in cystic fibrosis airway neutrophilsCell reports. MedicineApril 20, 2021Margaroli C, Moncada-Giraldo D, Gulick DA, Dobosh B, Giacalone VD, Forrest OA, Sun F, Gu C, Gaggar A, Kissick H, et al.Co,Cat#67042 RPMI 1640,Corning,Cat#10-040-CV CXCL-8,Biolegend,Cat#574202 LPS,Sigma,Cat#L9143 C5a,R&D systems,Cat#2037-C5-025/CF LTB4,Sigma,Cat#L0517 NEmo-1 probe,Sirius Fine Chemicals SiChem GmbH,Cat#SC-0200 SYTO RNASelect,Thermofisher,Cat#S32703 α-amanitin,Sigma,Cat#A2263 ,, Critical

(13) Complement Regulation in Human Tenocytes under the Influence of Anaphylatoxin C5aInternational journal of molecular sciencesMarch 18, 2021Silawal S, Kohl B, Shi J, Schulze-Tanzil G.

(14) Granulocyte and monocyte adsorptive apheresis induces apoptosis of neutrophils and release of a novel chemoattractant for desensitization of interleukin-8 response - In vitro and in vivo resultsCytokineMarch 1, 2021Kashiwagi N, Saito F, Maegawa H, Kaneda K.

(15) Interleukin 3-induced GITR promotes the activation of human basophilsCytokineDecember 1, 2020Hong L, Tang Y, Pan S, Xu M, Shi Y, Gao S, Sui C, He C, Zheng K, Tang R, et al.

(16) Transcriptome of the Aedes aegypti Mosquito in Response to Human Complement ProteinsInternational journal of molecular sciencesSeptember 9, 2020Giraldo-Calderón GI, Calle-Tobón A, Rozo-López P, Colpitts TM, Park Y, Rua-Uribe GL, Londono-Renteria B.

(17) Neutrophils from ANCA-associated vasculitis patients show an increased capacity to activate the complement system via the alternative pathway after ANCA stimulationPloS oneJanuary 1, 2019Ohlsson S, Holm L, Hansson C, Ohlsson SM, Gunnarsson L, Pettersson Å, Skattum L.

(18) Rapid and Efficient Production of Human Functional Mast Cells through a Three-Dimensional Culture of Adipose Tissue-Derived Stromal Vascular CellsJournal of immunology (Baltimore, Md. : 1950)December 15, 2018Paupert J, Espinosa E, Cenac N, Robert V, Laharrague P, Evrard SM, Casteilla L, Lorsignol A, Cousin B.

(19) Apigenin inhibits C5a-induced proliferation of human nasopharyngeal carcinoma cells through down-regulation of C5aRBioscience reportsMay 15, 2018Zhang Y, Cao Y, Zhang L, Feng C, Zhou G, Wen G.

(20) Broad adsorption of sepsis-related PAMP and DAMP molecules, mycotoxins, and cytokines from whole blood using CytoSorb® sorbent porous polymer beadsPloS oneJanuary 1, 2018Gruda MC, Ruggeberg KG, O'Sullivan P, Guliashvili T, Scheirer AR, Golobish TD, Capponi VJ, Chan PP.

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Recombinant Human Complement Component C5a Protein, CF from R&D Systems, a Bio-Techne Brand

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R&D Systems, a Bio-Techne Brand

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Recombinant Human Complement Component C5a Protein, CF from R&D Systems, a Bio-Techne Brand

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