IL-36Ra/IL-1F5 Protein 1275-IL-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-36Ra/IL-1F5 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $408.00Supplier Page View Company Product Page
Catalog Number1275-IL-025
SpeciesHuman
Size25 ug
Molecule NameIL-36Ra/IL-1F5
NCBI Full Gene Nameinterleukin 36 receptor antagonist
NCBI Gene AliasesFIL1, IL-36Ra, IL1L1, PSORS14, IL36RA, FIL1D, PSORP, IL1HY1, FIL1(DELTA), IL1RP3, IL1F5
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular Weight17 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human IL-36Ra/IL-1F5 Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 25 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) IL-36G promotes cancer-cell intrinsic hallmarks in human gastric cancer cellsCytokineJuly 1, 2022Le N, Luk I, Chisanga D, Shi W, Pang L, Scholz G, Mariadason J, Ernst M, Huynh J.

(2) IL-36γ and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell DeathAdvanced science (Weinheim, Baden-Wurttemberg, Germany)October 1, 2021Wang P, Yang W, Guo H, Dong HP, Guo YY, Gan H, Wang Z, Cheng Y, Deng Y, Xie S, et al.respectively, R&D system) with or without IL‐36Ra (20 ng per well, 210–36RA, Peprotech for mouse, and 1275‐IL‐025, R&D system for human, respectively) or NAC (5 mm, HY‐B0215, MedChemExpress) for 8 h. The cells were

(3) Interleukin (IL)-17/IL-36 axis participates to the crosstalk between endothelial cells and keratinocytes during inflammatory skin responsesPloS oneJanuary 1, 2020Mercurio L, Failla CM, Capriotti L, Scarponi C, Facchiano F, Morelli M, Rossi S, Pagnanelli G, Albanesi C, Cavani A, et al.

(4) IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatmentCell death & diseaseOctober 30, 2018Mercurio L, Morelli M, Scarponi C, Eisenmesser EZ, Doti N, Pagnanelli G, Gubinelli E, Mazzanti C, Cavani A, Ruvo M, et al.

(5) Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblastsEuropean journal of immunologyDecember 1, 2017Schmitt V, Hahn M, Kästele V, Wagner O, Wiendl M, Derer A, Taddeo A, Hahne S, Radbruch A, Jäck HM, et al.

(6) IL-36 induces cytokine IL-6 and chemokine CXCL8 expression in human lung tissue cells: Implications for pulmonary inflammatory responsesCytokineNovember 1, 2017Zhang J, Yin Y, Lin X, Yan X, Xia Y, Zhang L, Cao J.

(7) Structural and Functional Attributes of the Interleukin-36 ReceptorThe Journal of biological chemistryAugust 5, 2016Yi G, Ybe JA, Saha SS, Caviness G, Raymond E, Ganesan R, Mbow ML, Kao CC.

(8) Signal Transduction and Intracellular Trafficking by the Interleukin 36 ReceptorThe Journal of biological chemistrySeptember 25, 2015Saha SS, Singh D, Raymond EL, Ganesan R, Caviness G, Grimaldi C, Woska JR Jr, Mennerich D, Brown SE, Mbow ML, et al.

(9) Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1βmAbsJanuary 1, 2015Lacy SE, Wu C, Ambrosi DJ, Hsieh CM, Bose S, Miller R, Conlon DM, Tarcsa E, Chari R, Ghayur T, et al.(AbbVie), IL-1ra/IL-1F3, (R&D Systems, 280-RA-050), IL-18/IL-1F4 (AbbVie), IL-36Ra/IL-1F5 (R&D Systems, 1275-IL-025), IL-36α/IL-1F6 (R&D Systems 1078-IL-025), FIL1ζ /IL-1F7 (R&D Systems, 1975-IL-025), IL-36β/IL-1F8 (R&D Systems

(10) IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonistProceedings of the National Academy of Sciences of the United States of AmericaFebruary 21, 2012van de Veerdonk FL, Stoeckman AK, Wu G, Boeckermann AN, Azam T, Netea MG, Joosten LA, van der Meer JW, Hao R, Kalabokis V, et al.

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Recombinant Human IL-36Ra/IL-1F5 Protein

IL-36Ra/IL-1F5 Protein

IL-36Ra/IL-1F5 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (10)

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IL-36Ra/IL-1F5 Protein from R&D Systems, a Bio-Techne Brand

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