Z-LR-AMC Fluorogenic Peptide Substrate ES008 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemZ-LR-AMC Fluorogenic Peptide Substrate
CompanyR&D Systems, a Bio-Techne Brand
Price $265.00Supplier Page View Company Product Page
Catalog NumberES008
Size10 mg
ApplicationsBioactivity
SpeciesMulti-Species
Molecule NameProtease Substrates
StorageSamples are stable for up to twelve months from date of receipt at -20° C to -70° C. The substrate can be aliquoted and stored -20° C to -70° C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light

Specifications/Features

Available conjugates: Sizes Available: 10 mg

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Selective inhibition of cathepsin S elastolytic activity by exopolysaccharides from deep-sea hydrothermal bacteriaCarbohydrate polymersNovember 1, 2025David A, Rigoux B, Maszota-Zieleniak M, Sinquin C, Neau C, Zykwinska A, Saidi A, Lalmanach G, Samsonov SA, Colliec-Jouault S, et al.

(2) From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 VariantsJournal of Medicinal ChemistryApril 10, 2025Gabriel Lemieux, Jimena Pérez-Vargas, Antoine Désilets, Malihe Hassanzadeh, Connor A. H. Thompson, Alice Gravel-Trudeau, Alexandre Joushomme, Siobhan Ennis, Ivan Villanueva, Étienne Marouseau, et al.ES014), Boc-RVRR-AMC (Bachem, 4018735), Boc-IEGR-AMC (Bachem, 4004961), and Boc-Z-LR-AMC (Bio-Techne, ES008) were also obtained commercially. Black opaque 96-well plates were utilized for in vitro proteases studies,

(3) Hypoxia increases methylated histones to prevent histone clipping and heterochromatin redistribution during Raf-induced senescenceNucleic Acids ResearchJanuary 24, 2025Soojeong Chang, Ramhee Moon, Dowoon Nam, Sang-Won Lee, Insoo Yoon, Dong-Sung Lee, Seunghyuk Choi, Eunok Paek, Daehee Hwang, Junho K Hur, et al.#952-CY) and fluorogenic peptide substrate VII: Z-Leu-Arg-4-methyl-7-coumarylamide (Z-LR-AMC) (catalog #ES008) were purchased from R&D Systems (Minneapolis, MN, USA). The enzymatic reactions were initiated upon

(4) Discovery of a new class of cell-penetrating peptides by novel phage display platformScientific ReportsJune 11, 2024Jinsha Liu, John Heddleston, Douglas Raymond Perkins, Jack Jia Hua Chen, Ahmadreza Ghanbarpour, Bill William Smith, Rebecca Miles, Eitaro Aihara, Sepideh Afsharfor each cathepsin is as follows: cathepsin A (Cat. No. ES005, R&D Systems), cathepsin B/L (Cat. No. ES008, R&D Systems), cathepsin C (Cat. No. I-1215, Bachem), cathepsin D (Cat. No. ES001, R&D Systems), cathepsin

(5) Pharmacophore Virtual Screening Identifies Riboflavin as an Inhibitor of the Schistosome Cathepsin B1 Protease with Antiparasitic ActivityACS OmegaJune 11, 2024Ramon M. Cogo, Thaís F. A. Pavani, Ana C. A. Mengarda, Rayssa A. Cajas, Thainá R. Teixeira, Lucas Fukui-Silva, Yujie Uli Sun, Lawrence J. Liu, Dilini K. Amarasinghe, Michael C. Yoon, et al.hydrolysis of the peptidyl fluorogenic substrate, Z-Arg-Arg-7-amido-4-methylcoumarin (Z-RR-AMC; R&D Systems #ES008). In a 384-well black plate (Greiner #781091), enzyme (6.4 mg/mL S. mansoni extract or 1.33 μg/mL human cathepsin B

(6) Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and MalariaInternational journal of molecular sciencesApril 17, 2024Di Chio C, Starvaggi J, Totaro N, Previti S, Natale B, Cosconati S, Bogacz M, Schirmeister T, Legac J, Rosenthal PJ, et al.

(7) Potential differences in cleavage of the S protein and type-1 interferon together control human coronavirus infection, propagation, and neuropathology within the central nervous systemJournal of virologyApril 26, 2021Le Coupanec A, Desforges M, Kaufer B, Dubeau P, Côté M, Talbot PJ.enzymatic assay with the recommended speciﬁcations provided by the manufacturer with ﬂuorogenic substrate (catalog no. ES008 and ES014; all reagents were from R&D Systems). For furin, kindly provided by Robert Day, Km and Vmax

(8) ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscleFASEB journal : official publication of the Federation of American Societies for Experimental BiologyNovember 1, 2019Fuqua JD, Mere CP, Kronemberger A, Blomme J, Bae D, Turner KD, Harris MP, Scudese E, Edwards M, Ebert SM, et al.acid (MES) hydrate, 5 mM DTT; pH 5.0) containing 50 µM Z-Leu-Arg-7-amino-4-methyl coumarin substrate (ES008; R&D Systems, Minneapolis, MN, USA) in a 96-well black plate, and fluorescence was monitored (380 nm

(9) Prevention of crystalline silica-induced inflammation by the anti-malarial hydroxychloroquineInhalation ToxicologySeptember 27, 2019Rachel Burmeister, Joseph F. Rhoderick, Andrij Holiancathepsin substrate Z-LR-AMC (specific to cathepsin B, cathepsin L and cathepsin V; R&D systems cat. ES008) at 20 μL in PBS was added to 50 μL of whole lung lavage fluid in a total reaction volume of 150 μL.

(10) Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during TumorigenesisCellJune 28, 2018Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, et al.μM pefabloc, all Sigma-Aldrich) using 2 μg of protein lysate and 10 μM protease substrate z-LR-AMC (ES008, R&D Systems). Increase of fluorescence was measured at 390/485 nm on a spectrophotometer (Fluostar Omega

(11) Role of engineered metal oxide nanoparticle agglomeration in reactive oxygen species generation and cathepsin B release in NLRP3 inflammasome activation and pulmonary toxicityInhalation toxicologyDecember 1, 2016Sager TM, Wolfarth M, Leonard SS, Morris AM, Porter DW, Castranova V, Holian A.

(12) Redundancy between Cysteine Cathepsins in Murine Experimental Autoimmune EncephalomyelitisPloS oneJanuary 1, 2015Allan ER, Yates RM.

(13) Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stageCell researchMarch 1, 2014Zhao L, Hua T, Crowley C, Ru H, Ni X, Shaw N, Jiao L, Ding W, Qu L, Hung LW, et al.measured by their abilities to cleave the fluorogenic peptide substrates Z-LR-AMC (R&D Systems, Catalog #: ES008) and Mca-RPKPVENval-WRK(Dnp)-NH2 (R&D Systems, Catalog #: ES002), respectively. Human cystatin C and

(14) The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and corneaFASEB journal : official publication of the Federation of American Societies for Experimental BiologyOctober 1, 2010Zeeuwen PL, van Vlijmen-Willems IM, Cheng T, Rodijk-Olthuis D, Hitomi K, Hara-Nishimura I, John S, Smyth N, Reinheckel T, Hendriks WJ, et al.

(15) Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornificationThe Journal of biological chemistryJune 9, 2006Cheng T, Hitomi K, van Vlijmen-Willems IM, de Jongh GJ, Yamamoto K, Nishi K, Watts C, Reinheckel T, Schalkwijk J, Zeeuwen PL.

(16) Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5Archives of biochemistry and biophysicsMay 15, 2006Cortesio CL, Jiang W.

(17) Distinct roles for cysteine cathepsin genes in multistage tumorigenesisGenes & developmentMarch 1, 2006Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D, Joyce JA.

(18) Characterization of cathepsin L secreted by Sf21 insect cellsArchives of biochemistry and biophysicsDecember 1, 2005Johnson GD, Jiang W.

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Z-LR-AMC Fluorogenic Peptide Substrate from R&D Systems, a Bio-Techne Brand

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Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (18)

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Z-LR-AMC Fluorogenic Peptide Substrate from R&D Systems, a Bio-Techne Brand

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