Boc-VPR-AMC Fluorogenic Peptide Substrate ES011 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemBoc-VPR-AMC Fluorogenic Peptide Substrate
CompanyR&D Systems, a Bio-Techne Brand
Price $265.00Supplier Page View Company Product Page
Catalog NumberES011
Size20 mg
SpeciesMulti-Species
Molecule NameProtease Substrates
StorageSamples are stable for up to twelve months from date of receipt at -20° C to -70° C. The substrate can be aliquoted and stored -20° C to -70° C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light
Source/Expression SystemSynthetic

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Heating up the Blunts: Prothrombin Activation, with Factor Va as an Obligate Cofactor, Is the Dominant Procoagulant Mechanism of Blunt-Nosed Viper Venoms (Macrovipera Species)ToxinsAugust 8, 2025Champagne PS, Seneci L, Fry BG.ddH2O, and finally priming with the reaction substrate solution containing Fluorogenic Peptide Substrate ES011 (Boc-Val-Pro-Arg-AMC; R&D Systems, catalog #ES011, Minneapolis, MN, USA) diluted in 5 mM CaCl2 + OK

(2) Influence of sodium Bituminosulfonate and Doxycycline on signal molecules relevant for rosacea symptomsScientific reportsMay 23, 2025Rein AS, Henke M, Brünner S, Luckhardt S, Zodel AL, Sethmann A, Schiffmann S.

(3) Snake Venom Makeover: Age-Dependent Variations in Procoagulant Biochemistry of Egyptian Saw-Scaled Viper (Echis pyramidum pyramidum) VenomToxins (Basel)March 19, 2025Alex Barker, Lee Jones, Lachlan A. Bourke, Lorenzo Seneci, Abhinandan Chowdhury, Aude Violette, Rudy Fourmy, Raul Soria, Matt Aldridge, Bryan G. FrySubstrate (ES011Boc-Val-Pro-Arg-AMC. Boc: t-Butyloxycarbonyl; 7-Amino-4-methylcoumarin; R & D systems, Cat# ES011, Minneapolis, Minnesota) in 500:1 ratio to start the reaction.The plate was warmed up at 37 °C.The plate

(4) Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanomaNat CommunMarch 10, 2025Manon Bulliard, Katarina Pinjusic, Laura Iacobucci, Céline Schmuziger, Nadine Fournier, Daniel B. ConstamTris•HCl, pH 9) for 1 hr at 37 °C, together with 0.1 mM fluorogenic Boc-VPR-AMC substrate (R&D Systems, ES011). 0.5 ng of rKLK5 was incubated in 100 µL KLK5 Assay buffer (0.1 M NaH2PO4, pH 8) for 1 hr at 37 °C,

(5) Age Is Just a Number: Ontogenetic Conservation in Activation of Blood Clotting Factors VII, X, and XII by Caucasus Blunt-Nosed Viper (Macrovipera lebetina obtusa) VenomsToxins (Basel)December 2, 2024Katrina Kempson, Abhinandan Chowdhury, Aude Violette, Rudy Fourmy, Raul Soria, Bryan G. FrySubstrate (ES011Boc-Val-Pro-Arg-AMC. Boc: t-Butyloxycarbonyl; 7-Amino-4-methylcoumarin; R & D systems, Cat# ES011, Minneapolis, MN, USA) in a 500:1 ratio, to each well to start the reaction. The plate was warmed up

(6) From Venom to Vein: Factor VII Activation as a Major Pathophysiological Target for Procoagulant Australian Elapid Snake VenomsToxins (Basel)October 6, 2024Uthpala Chandrasekara, Abhinandan Chowdhury, Lorenzo Seneci, Christina N. Zdenek, Nathan Dunstan, Bryan G. Fryprothrombin activation, thereby acting as a trigger. The buffer included the fluorescent substrate ES011 (Boc-Val-Pro-Arg-AMC; Boc = t-Butyloxycarbonyl; AMC = 7-Amino-4-methylcoumarin; R & D systems, catalogue#

(7) Tiny but Mighty: Vipera ammodytes meridionalis (Eastern Long-Nosed Viper) Ontogenetic Venom Variations in Procoagulant Potency and the Impact on Antivenom EfficaciesToxinsSeptember 14, 2024Qiao Z, Jones L, Bourke LA, Seneci L, Chowdhury A, Violette A, Fourmy R, Soria R, Aldridge M, Fry BG.Substrate (ES011Boc-Val-Pro-Arg-AMC. Boc: t-Butyloxycarbonyl; 7-Amino-4-methylcoumarin; R & D systems, Cat# ES011, Minneapolis, MN, USA) in a 500:1 ratio, to each well to start the reaction. The plate was warmed up

(8) The Clot Thickens: Differential Coagulotoxic and Cardiotoxic Activities of Anguimorpha Lizard VenomsToxins (Basel)June 20, 2024James Dobson, Abhinandan Chowdhury, Jeremie Tai-A-Pin, Harold van der Ploeg, Amber Gillett, Bryan G. FryμL of buffer (5 mM CaCl2,150 mM NaCl, and 50 mM Tri-HCl [pH 7.3]) and Fluorogenic Peptide Substrate ES011 (Boc-Val-Pro-Arg-AMC. Boc: t-Butyloxycarbonyl; 7-Amino-4-methylcoumarin; R&D systems, catalogue# ES011,

(9) Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier BenefitsInternational journal of molecular sciencesOctober 19, 2022Smiljanic S, Messaraa C, Lafon-Kolb V, Hrapovic N, Amini N, Osterlund C, Visdal-Johnsen L.interference effect of colored extracts. Fifty microliter of 100 µM substrate Boc-VPR-AMC (R&D Systems, ES011) was then added to the plate and incubated 15 min at room temperature, followed by fluorescence reading

(10) WDR72 regulates vesicle trafficking in ameloblastsScientific reportsFebruary 18, 2022Katsura K, Nakano Y, Zhang Y, Shemirani R, Li W, Den Besten P.

(11) Chlorogenic Acid Isomers Isolated from Artemisia lavandulaefolia Exhibit Anti-Rosacea Effects In VitroBiomedicinesFebruary 16, 2022Roh KB, Jang Y, Cho E, Park D, Kweon DH, Jung E.

(12) A Genus-Wide Bioactivity Analysis of Daboia (Viperinae: Viperidae) Viper Venoms Reveals Widespread Variation in Haemotoxic PropertiesInternational journal of molecular sciencesDecember 15, 2021Op den Brouw B, Coimbra FCP, Casewell NR, Ali SA, Vonk FJ, Fry BG.

(13) Venom-Induced Blood Disturbances by Palearctic Viperid Snakes, and Their Relative Neutralization by Antivenoms and Enzyme-InhibitorsFrontiers in ImmunologyJune 10, 2021Abhinandan Chowdhury et al.Substrate, (ES011Boc-Val-Pro-Arg-AMC. Boc: t-Butyloxycarbonyl; 7-Amino-4-methylcoumarin; R & D systems, Cat# ES011, Minneapolis, Minnesota) in 500:1 ratio to start the reaction; with the plate warmed up at 37°C and

(14) Interleukin-1β-induced matrix metalloproteinase-3 via ERK1/2 pathway to promote mesenchymal stem cell migrationPloS oneJanuary 1, 2021Chang CH, Lin YL, Tyan YS, Chiu YH, Liang YH, Chen CP, Wu JC, Wang HS.

(15) Do Antibiotics Potentiate Proteases in Hemotoxic Snake Venoms?Toxins (Basel)April 9, 2020Christoffer V. Sørensen, Cecilie Knudsen, Ulrich Auf dem auf dem Keller, Konstantinos Kalogeropoulos, Cristina Gutiérrez-Jiménez, Manuela B. Pucca, Eliane C. Arantes, Karla C. F. Bordon, Andreas H. Laustsenpeptide-based substrate assay, which monitors the cleavage of a fluorogenic peptide substrate (Cat#ES011, R&D systems, Minneapolis, MI, USA) that is a known cleavage substrate for different serine proteases

(16) Habu coagulotoxicity: Clinical implications of the functional diversification of Protobothrops snake venoms upon blood clotting factorsToxicology in VitroMarch 1, 2019Jordan Debono, Mettine H.A. Bos, Amanda Nouwens, Lilin Ge, Nathaniel Frank, Hang Fai Kwok, Bryan G. FrymM Tri-HCl (pH 7.3), Fluorogenic Peptide Substrate, R & D systems, Cat#ES001, ES003, ES005, ES010, ES011, Minneapolis, Minnesota). Fluorescence was monitored by a Fluoroskan Ascent™ (Thermo Scientific, Vantaa,

(17) Human kallikrein-related peptidase 12 stimulates endothelial cell migration by remodeling the fibronectin matrixScientific reportsApril 20, 2018Kryza T, Parent C, Pardessus J, Petit A, Burlaud-Gaillard J, Reverdiau P, Iochmann S, Labas V, Courty Y, Heuzé-Vourc'h N.

(18) Correlation between ontogenetic dietary shifts and venom variation in Australian brown snakes ( Pseudonaja )Comparative Biochemistry and Physiology Part C: Toxicology & PharmacologyJuly 1, 2017Vittoria Cipriani, Jordan Debono, Jonathan Goldenberg, Timothy N.W. Jackson, Kevin Arbuckle, James Dobson, Ivan Koludarov, Bin Li, Chris Hay, Nathan Dunstan, et al.+ substrate Coagulation Venom + fVII + R&D systems™) Factor VIIa substrate AC (Haematologic CE SN-17a PT ES011 (Bio-techne/ Technologies Inc.) Thrombin Venom + human prothrombin + In vitro activity Activity

(19) Protease-Inhibitor Interaction Predictions: Lessons on the Complexity of Protein-Protein InteractionsMolecular & cellular proteomics : MCPJune 1, 2017Fortelny N, Butler GS, Overall CM, Pavlidis P.by the suppliers. KLK5 (Catalogue# 1108-S.E.-010) and its quenched fluorescent substrate (Catalogue# ES011) and kallikrein 5 (KLK7, Catalogue# 2624-S.E.-010) and its quenched fluorescent substrate (Catalogue#

(20) Coagulating Colubrids: Evolutionary, Pathophysiological and Biodiscovery Implications of Venom Variations between Boomslang (Dispholidus typus) and Twig Snake (Thelotornis mossambicanus)ToxinsMay 19, 2017Debono J, Dobson J, Casewell NR, Romilio A, Li B, Kurniawan N, Mardon K, Weisbecker V, Nouwens A, Kwok HF, et al.buffer, 150 mM NaCl, and 50 mM Tri-HCl (pH 7.3), Fluorogenic Peptide Substrate, R&D systems, Cat#ES001 & ES011, Minneapolis, MI, USA). Fluorescence was monitored by a Fluoroskan Ascent™ (Thermo Scientific, Vantaa,

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Boc-VPR-AMC Fluorogenic Peptide Substrate from R&D Systems, a Bio-Techne Brand

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R&D Systems, a Bio-Techne Brand

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Boc-VPR-AMC Fluorogenic Peptide Substrate from R&D Systems, a Bio-Techne Brand

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