Mca-RPPGFSAFK(Dnp)-OH Fluorogenic Peptide Substrate ES005 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemMca-RPPGFSAFK(Dnp)-OH Fluorogenic Peptide Substrate
CompanyR&D Systems, a Bio-Techne Brand
Price $337.00Supplier Page View Company Product Page
Catalog NumberES005
Size1 mg
ApplicationsBioactivity, Binding Activity
Purity>95%, by HPLC
SpeciesMulti-Species
Molecule NameProtease Substrates
StorageSamples are stable for up to twelve months from date of receipt at -20° C to -70° C. The substrate can be aliquoted and stored -20° C to -70° C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light

Specifications/Features

Available conjugates: Sizes Available: 1 mg

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Angiotensin-(1–7) modulates gut-bone marrow axis in diabetesBiochemical PharmacologyNovember 1, 2025Kishore Chittimalli, Ishan Manandhar, Stephen Adkins, Manseb Rahman, Andrew Toelle, Ramakumar Tummala, Bina Joe, Yagna P.R. Jarajapuactivities in the colon tissue lysates was carried out by using enzyme-specific fluorogenic substrates (ES005 and ES007, R&D Systems, Minneapolis MN), as described before.27 Enzyme-specific inhibitors, captopril

(2) Exploiting the angiotensin-converting enzyme pathway to augment endogenous opioid signalingCommun BiolOctober 14, 2025Prakashkumar Dobariya, Jessica Williams, Filip Hanak, Patrick E. Rothwell, Swati S. Moreassay Recombinant mouse ACE1 enzyme (Cat# 1513-ZN) and fluorogenic peptide substrate Mca-RPPGFSAFK(Dnp)-OH (Cat# ES005) were purchased from R&D Systems. MES (Cat# M-8250), substrates Abz-SDK(Dnp)-OH (Cat# A5730), Abz-LFK(Dnp)-OH

(3) Interactions of substrates and phosphinyl containing inhibitors with bacterial and human zinc proteasesPLoS OneAugust 1, 2025Fatema Amatur Rahman, Imin Wushur, Ida Kristine Østnes Hansen, Tor Haug, Klara Stensvåg, Bibek Chaulagain, Tra-Mi Nguyen, Olayiwola Adedotun Adekoya, Nabin Malla, Jan-Olof Winberg, et al.from Calbiochem (San Diego, CA, USA), while ALN was from BioCentrum Ltd (Kraków, Poland). ES001 and ES005 were from R&D Systems (Minneapolis, MN, USA). Mca-PL-OH was from Bachem AG (Basel, Switzerland). Trifluoroacetic

(4) Neprilysin 2 catalyses the degradation of natriuretic peptides despite sacubitrilat InhibitionScientific reportsJuly 28, 2025Selezneva EM, Feygina EE, Ageeva LV, Rozov FN, Kopylova IV, Altshuler EP, Semenov AG.

(5) Discovery of a new class of cell-penetrating peptides by novel phage display platformScientific ReportsJune 11, 2024Jinsha Liu, John Heddleston, Douglas Raymond Perkins, Jack Jia Hua Chen, Ahmadreza Ghanbarpour, Bill William Smith, Rebecca Miles, Eitaro Aihara, Sepideh Afsharfluorogenic peptide-substrate. The peptide substrate for each cathepsin is as follows: cathepsin A (Cat. No. ES005, R&D Systems), cathepsin B/L (Cat. No. ES008, R&D Systems), cathepsin C (Cat. No. I-1215, Bachem), cathepsin D

(6) Obese Male Mice Exposed to Early Life Stress Display Sympathetic Activation and Hypertension Independent of Circulating Angiotensin IIJournal of the American Heart AssociationJanuary 2, 2024Dalmasso C, Ahmed NS, Ghuneim S, Cincinelli C, Leachman JR, Giani JF, Cassis L, Loria AS.

(7) Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH RangeBiochemistryAugust 1, 2023Yoon MC, Phan V, Podvin S, Mosier C, O'Donoghue AJ, Hook V.ng/μL). Since cathepsin X cannot cleave any of the AMC substrates, MCA-RPPGFSAFK(Dnp)-OH (R&D Systems #ES005) was used to verify that cathepsin X was active. Kinetic Parameters of Cathepsin B Assessed by kcat

(8) Reduced Expression of Voltage-Gated Sodium Channel Beta 2 Restores Neuronal Injury and Improves Cognitive Dysfunction Induced by Aβ1-42Neural plasticityJanuary 1, 2022Li S, Yan GJ, Tan YX, Xue LL, Wang TH, Zhao HR, Lu MN, Zhang HX, Mei R, Dong XH, et al.R&D Systems, AF1182, USA), 5 μM MCA RPPGFSAFK (DNP) OH fluorescent peptide substrate (R&D Systems, ES005, USA), and HEPES buffer (pH 7.4, Invitrogen, 28398, USA) and incubated at room temperature for 30 min.

(9) Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc MetalloproteasesMolecules (Basel, Switzerland)December 22, 2021Rahman F, Wushur I, Malla N, Åstrand OAH, Rongved P, Winberg JO, Sylte I.Aureolysin was from BioCentrum Ltd. (Kraków, Poland). McaPLGL(Dpa)AR-NH2 (ES001) and McaRPPGFSAFK(Dnp)-OH (ES005) were from R&D Systems (Minneapolis, MN, USA). 3.2. Compounds for Testing Twenty TPA, DPA, TPEN, pyridine

(10) Inhibition of bacterial and human zinc-metalloproteases by bisphosphonate- and catechol-containing compoundsJournal of enzyme inhibition and medicinal chemistryDecember 1, 2021Rahman F, Nguyen TM, Adekoya OA, Campestre C, Tortorella P, Sylte I, Winberg JO.Aureolysin was from BioCentrum Ltd (Kraków, Poland). McaPLGL(Dpa)AR-NH2 (ES001) and McaRPPGFSAFK(Dnp)-OH (ES005) were from R&D Systems (Minneapolis, MN, USA). Synthesis of compounds Synthesis of compounds tested

(11) Medium-Chain Length Fatty Acids Enhance Aβ Degradation by Affecting Insulin-Degrading EnzymeCellsOctober 29, 2021Mett J, Lauer AA, Janitschke D, Griebsch LV, Theiss EL, Grimm HS, Koivisto H, Tanila H, Hartmann T, Grimm MOW.

(12) ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in agingGeroScienceJune 1, 2021Joshi S, Chittimalli K, Jahan J, Vasam G, Jarajapu YP.in the cell lysates or plasma and cell supernatants by using enzyme-specific fluorogenic substrates (ES005 and ES007 for ACE and ACE2, respectively, R&D Systems), as reported before [31]. Enzyme-specific inhibitors,

(13) ACE2 gene transfer ameliorates vasoreparative dysfunction in CD34+ cells derived from diabetic older adultsClinical science (London, England : 1979)January 29, 2021Joshi S, Montes de Oca I, Maghrabi A, Lopez-Yang C, Quiroz-Olvera J, Garcia CA, Jarajapu YPR.in the cell lysates or plasma and cell supernatants by using enzyme-specific fluorogenic substrates (ES005 and ES007 for ACE and ACE2, respectively, R&D Systems), as reported before [25]. Enzyme-specific inhibitors,

(14) High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activityThe Journal of biological chemistryDecember 25, 2020Lu J, Sun PD.Mca-YVADAPK(Dnp)-OH (ES007) was used as an angiotensin II like substrate and Mca-RPPGFSAFK(Dnp)-OH(ES005) was a fluorogenic peptide derivative of Bradykinin according to manufacturer's instruction. Nonfluorogenic

(15) Cathepsin A contributes to left ventricular remodeling by degrading extracellular superoxide dismutase in miceThe Journal of biological chemistrySeptember 4, 2020Hohl M, Mayr M, Lang L, Nickel AG, Barallobre-Barreiro J, Yin X, Speer T, Selejan SR, Goettsch C, Erb K, et al.

(16) High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activitybioRxiv : the preprint server for biologyJuly 1, 2020Lu J, Sun PD.Mca-YVADAPK(Dnp)-OH (ES007) was used as an angiotensin II like substrate and Mca-RPPGFSAFK(Dnp)-OH(ES005) was a fluorogenic peptide derivative of Bradykinin according to manufacturer’s instruction. Non-fluorogenic

(17) Female Mice Exposed to Postnatal Neglect Display Angiotensin II-Dependent Obesity-Induced HypertensionJournal of the American Heart AssociationDecember 3, 2019Dalmasso C, Leachman JR, Ensor CM, Yiannikouris FB, Giani JF, Cassis LA, Loria AS.

(18) Hypoxic regulation of angiotensin-converting enzyme 2 and Mas receptor in human CD34(+) cellsJournal of cellular physiologyNovember 1, 2019Joshi S, Wollenzien H, Leclerc E, Jarajapu YP.determined in the CD34+ cell-lysates and cell-supernatants by using enzyme-specific fluorogenic substrates (ES005 for ACE and ES007 for ACE2; R&D Systems), respectively, as described before. (Joshi, Balasubramanian,

(19) Neuroprotection induced by Navβ2‑knockdown in APP/PS1 transgenic neurons is associated with NEP regulationMolecular medicine reportsAugust 1, 2019Hu T, Li SS, Lu MN, Zhang L, Chen B, Mao R, Mei R, Tan YX, Li S, Xiyang YB.

(20) Habu coagulotoxicity: Clinical implications of the functional diversification of Protobothrops snake venoms upon blood clotting factorsToxicology in VitroMarch 1, 2019Jordan Debono, Mettine H.A. Bos, Amanda Nouwens, Lilin Ge, Nathaniel Frank, Hang Fai Kwok, Bryan G. FrymM NaCl, and 50 mM Tri-HCl (pH 7.3), Fluorogenic Peptide Substrate, R & D systems, Cat#ES001, ES003, ES005, ES010, ES011, Minneapolis, Minnesota). Fluorescence was monitored by a Fluoroskan Ascent™ (Thermo Scientific,

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Mca-RPPGFSAFK(Dnp)-OH Fluorogenic Peptide Substrate from R&D Systems, a Bio-Techne Brand

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R&D Systems, a Bio-Techne Brand

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Mca-RPPGFSAFK(Dnp)-OH Fluorogenic Peptide Substrate from R&D Systems, a Bio-Techne Brand

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