Recombinant Mouse IL-27 (NS0-expressed) Protein, CF 2799-ML-010/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Mouse IL-27 (NS0-expressed) Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $449.00Supplier Page View Company Product Page
Catalog Number2799-ML-010/CF
SpeciesMouse
FormatLyophilized from a 0.2 µm filtered solution in PBS and CHAPS
Size10 ug
Molecule NameIL-27
NCBI Full Gene NameEpstein-Barr virus induced gene 3, interleukin 27
NCBI Gene AliasesEBI-3, IL-27-A, IL27-A, IL-27p28, IL-27, Il30, p28
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 60-65 kDa, reducing conditions
Theoretical: 48.7 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Mouse IL-27 (NS0-expressed) Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sicknessCellJanuary 8, 2026Liu Yang, Matias L. Andina, Mario Witkowski, Hunter King, Ian Wickersham, Jun R. Huh, Gloria B. Choi,R&D Systems,418-ML-025/CF IL-12,R&D Systems,419-ML-050/CF IL-23,R&D Systems,1887-ML-010/CF IL-27,R&D Systems,2799-ML-010/CF IL-10,R&D Systems,417-ML-025/CF IL-20,R&D Systems,1204-ML-025/CF IL-22,R&D Systems,582-ML-010/CF IFN-α

(2) Cell type specific IL-27p28 (IL-30) deletion in mice uncovers an unexpected regulatory function of IL-30 in autoimmune inflammationScientific reportsFebruary 1, 2023Kim D, Kim S, Kang MS, Yin Z, Min B.

(3) IL-27 induces LL-37/CRAMP expression from intestinal epithelial cells: implications for immunotherapy of Clostridioides difficile infectionGut MicrobesAugust 25, 2021Banglao Xu, Xianan Wu, Yi Gong, Ju Caoinfection. Reagents Recombinant human IL-27 (Catalog number: 2526-IL-010/CF) or mouse (Catalog number: 2799-ML-010/CF) IL-27 protein was purchased from R&D Systems (Minneapolis, MN). Mouse CRAMP (mouse homolog for human

(4) A critical role for Th17 cell-derived TGF-β1 in regulating the stability and pathogenicity of autoimmune Th17 cellsExperimental & molecular medicineMay 1, 2021Choi G, Park YJ, Cho M, Moon H, Kim D, Kang CY, Chung Y, Kim BS.

(5) An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell SubsetsCell reportsNovember 24, 2020Zhang H, Madi A, Yosef N, Chihara N, Awasthi A, Pot C, Lambden C, Srivastava A, Burkett PR, Nyman J, et al.

(6) Autocrine TGF-β1 Maintains the Stability of Foxp3(+) Regulatory T Cells via IL-12Rβ2 DownregulationBiomoleculesMay 27, 2020Choi G, Na H, Kuen DS, Kim BS, Chung Y.

(7) The Inhibition of Group II Innate Lymphoid Cell Response by IL-27 in Allergic RhinitisJournal of immunology researchJanuary 1, 2020Luo X, Zeng Q, Li Y, Tang Y, Liu W, Luo R.

(8) Interleukin 27 Protects From Gastric Atrophy and Metaplasia During Chronic Autoimmune GastritisCellular and molecular gastroenterology and hepatologyJanuary 1, 2020Bockerstett KA, Petersen CP, Noto CN, Kuehm LM, Wong CF, Ford EL, Teague RM, Mills JC, Goldenring JR, DiPaolo RJ.mice with co-housed littermate controls. For pump implantation studies, 800 ng of carrier-free rIL27 (2799-ML-010/CF; R&D Systems, Minneapolis, MN) in 200 uL of sterile PBS was loaded into mini osmotic pumps (model 2004;

(9) Adoptive transfer of type 1 regulatory T cells suppressed the development of airway hyperresponsiveness in ovalbumin-induced airway inflammation model miceJournal of pharmacological sciencesDecember 1, 2019Matsuda M, Doi K, Tsutsumi T, Inaba M, Hamaguchi J, Terada T, Kawata R, Kitatani K, Nabe T.

(10) IL-27 targets Foxp3+ Tregs to mediate antiinflammatory functions during experimental allergic airway inflammationJCI insightJanuary 24, 2019Nguyen QT, Jang E, Le HT, Kim S, Kim D, Dvorina N, Aronica MA, Baldwin WM 3rd, Asosingh K, Comhair S, et al.

(11) Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitisPloS oneJanuary 1, 2019Abdullah A, Maged M, Hairul-Islam M I, Osama I A, Maha H, Manal A, Hamza H.

(12) Indole-3-Pyruvic Acid, an Aryl Hydrocarbon Receptor Activator, Suppresses Experimental Colitis in MiceJournal of immunology (Baltimore, Md. : 1950)December 15, 2018Aoki R, Aoki-Yoshida A, Suzuki C, Takayama Y.

(13) Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infectionMucosal immunologySeptember 1, 2018Ting HA, de Almeida Nagata D, Rasky AJ, Malinczak CA, Maillard IP, Schaller MA, Lukacs NW.

(14) γδTCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritisScientific reportsMay 15, 2018Bouchareychas L, Grössinger EM, Kang M, Adamopoulos IE.

(15) Treg-specific IL-27Rα deletion uncovers a key role for IL-27 in Treg function to control autoimmunityProceedings of the National Academy of Sciences of the United States of AmericaSeptember 19, 2017Do J, Kim D, Kim S, Valentin-Torres A, Dvorina N, Jang E, Nagarajavel V, DeSilva TM, Li X, Ting AH, et al.

(16) The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine MacrophagesJournal of immunology (Baltimore, Md. : 1950)September 1, 2017Carson WF 4th, Cavassani KA, Soares EM, Hirai S, Kittan NA, Schaller MA, Scola MM, Joshi A, Matsukawa A, Aronoff DM, et al.

(17) Balanced Bcl-3 expression in murine CD4⁺ T cells is required for generation of encephalitogenic Th17 cellsEuropean journal of immunologyAugust 1, 2017Mufazalov IA, Kuschmann J, Andruszewski D, Masri J, Gabriel LA, Adams P, Reissig S, Hövelmeyer N, Waisman A.

(18) STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral InfectionJournal of immunology (Baltimore, Md. : 1950)July 15, 2017Stier MT, Goleniewska K, Cephus JY, Newcomb DC, Sherrill TP, Boyd KL, Bloodworth MH, Moore ML, Chen K, Kolls JK, et al.

(19) Interleukin-27 is elevated in sepsis-induced myocardial dysfunction and mediates inflammationCytokineDecember 1, 2016Gao F, Yang YZ, Feng XY, Fan TT, Jiang L, Guo R, Liu Q.

(20) IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque MiceJournal of immunology (Baltimore, Md. : 1950)October 15, 2016Vijayan D, Mohd Redzwan N, Avery DT, Wirasinha RC, Brink R, Walters G, Adelstein S, Kobayashi M, Gray P, Elliott M, et al.

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IL-27 Protein

IL-27 Protein

IL-27 Protein

IL-27 Protein

IL-27 Protein

Recombinant Mouse IL-27 (NS0-expressed) Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Mouse IL-27 (NS0-expressed) Protein, CF from R&D Systems, a Bio-Techne Brand

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