Recombinant Mouse IL-4 Protein, CF 404-ML-010/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Mouse IL-4 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $257.00Supplier Page View Company Product Page
Catalog Number404-ML-010/CF
SpeciesMouse
Molecule NameIL-4
Size10 ug (also 25 ug, 50 ug, 100 ug, 1000 ug)
FormatLyophilized from a 0.2 µm filtered solution in PBS
NCBI Full Gene Nameinterleukin 4
NCBI Gene AliasesIl-4, BSF-1
Purity>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular Weight14 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Mouse IL-4 Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) CD207‐Positive Dendritic Cells Promote Emphysema Through CD8 + T Cell Pathway in Chronic Obstructive Pulmonary DiseaseAdvanced ScienceMarch 1, 2026Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, et al.penicillin‐streptomycin, recombinant mouse GM‐CSF (20 ng/mL; R&D Systems, #415‐ML‐005), and IL‐4 (20 ng/mL; R&D Systems, #404‐ML‐010/CF). Half of the culture medium was replaced with fresh, cytokine‐containing medium every 2 days. After

(2) Complement receptor C3ar1 deficiency does not alter brain structure or functional connectivity across early life developmentBrain CommunicationsOctober 30, 2025Hanna Lemmik, Eugene Kim, Eilidh MacNicol, Davide Maselli, Michel Bernanos, Zhuoni Li, Dauda Abdullahi, Esther Walters, Maria Elisa Serrano Navacerrada, Wuding Zhou, et al.for 72 h. On day three, the medium was refreshed, and 50 ng/ml recombinant mouse IL4 (R&D Systems, #404-ML-010/CF) was added to half of the wells to skew them towards M2 phenotype. Incubation continued for an additional

(3) Spleen-targeted NeoPol-mL242 mRNA vaccine induces robust T-cell responses in a hepatocellular carcinoma modelJournal of NanobiotechnologySeptember 2, 2025Yufei Wu, Gongrui Sun, Wendan Ren, Yang Gui, Cong Wang, Xinyi Ye, Yun Chen, Xiufeng Pang, Qi Zhang, Zi Jun Wang, et al.isolated from the femurs of C57BL/6 mice, and cultured in the presence of 10 ng/mL IL-4 (R&D Systems, 404-ML-010/CF) and 20 ng/mL mGM-CSF (R&D Systems, 415-ML-020/CF) to promote differentiation. Then, the cells were

(4) Locally Reprogramming Tumor-Associated Macrophages with Cytokine-Loaded Injectable Cryogels for Breast CancerAnnals of Biomedical EngineeringAugust 29, 2025Sydney R. Henriques, Evan B. Glass, Kristen L. Hoek, Ori Z. Chalom, Abigail E. Manning, Sohini Roy, Diana K. Graves, Sarah M. Goldstein, Benjamin C. Hacker, Renjie Jin, et al.media was prepared as previously described [40]. BMDMs were treated with 10 ng/mL IL-4 (R&D Systems; 404-ML-010/CF) and 20 ng/mL IL-13 (R&D Systems; 413-ML-005/CF) for four days for M2 polarization or 100 ng/mL IFN-γ

(5) Inflammatory cytokine interleukin-18 prevents murine miscarriage by inducing appropriate inflammationScientific reportsAugust 21, 2025Horii Y, Ino H, Sasaki F, Ishibashi M, Koike E, Kawamoto Y, Flavell RA, Ohashi R, Suzuki S, Negishi Y, et al.(485-ML-100/CF, R&D Systems Inc., Minneapolis, MN) 0.01 µg/body from Gd 5.5 to 12.5 and recombinant IL-4 (404-ML-010/CF, R&D Systems Inc.) 1 µg/body from Gd 8.5 to 12.5. Miscarriages were determined at Gd 13.5. ELISA IL-18

(6) Rocaglamide Suppresses Allergic Reactions by Regulating IL-4 Receptor SignalingMolecules (Basel, Switzerland)February 11, 2025Jo H, Kim M, Jeoung J, Kim W, Park YH, Jung HS, Lee W, Jeoung D.Cell Signaling (7076, Danvers, MA, USA). Recombinant mouse IL-4 protein was purchased from R&D system (404-ML-010/CF, Minneapolis, MN, USA). Neutralizing IL-4 antibody (nIL-4) was purchased from Invitrogen (AMC0044, Waltham,

(7) Diverse potential of secretome from natural killer cells and monocyte-derived macrophages in activating stellate cellsFrontiers in ImmunologyApril 3, 2024Julia Sauer, Agnes A. Steixner-Kumar, Svenja Gabler, Maciej Motyka, Jörg F. Rippmann, Stefan Brosa, Dennis Boettner, Tanja Schönberger, Charlotte Lempp, Vanessa Frodermann, et al.The PCLS were exposed to 100 ng/mL rmM-CSF (R&D Systems, #416-ML/CF), 118 ng/mL rmIL-4 (R&D Systems, #404-ML-010/CF), 256 ng/mL rmIL-13 (R&D Systems, #413-ML-005/CF), 20 ng/mL rmTNFα (R&D Systems, #410-MT/CF), and 100

(8) Dual activity of Minnelide chemosensitize basal/triple negative breast cancer stem cells and reprograms immunosuppressive tumor microenvironmentResearch squareFebruary 22, 2024Korkaya H, Koksalar Alkan F, Caglayan A, Alkan H, Benson E, Gunduz Y, Sensoy O, Durdagi S, Zarbaliyev E, Dyson G, et al.

(9) Guidelines for mouse and human DC functional assaysEuropean journal of immunologyDecember 1, 2023Clausen BE, Amon L, Backer RA, Berod L, Bopp T, Brand A, Burgdorf S, Chen L, Da M, Distler U, et al.

(10) Mutual modulation of gut microbiota and the immune system in type 1 diabetes modelsNature communicationsNovember 27, 2023Rosell-Mases E, Santiago A, Corral-Pujol M, Yáñez F, Varela E, Egia-Mendikute L, Arpa B, Cosovanu C, Panosa A, Serrano-Gómez G, et al.anti-CD40 (αCD40) monoclonal antibody (BD Pharmingen, Cat#553787) at 10 µg/mL plus IL-4 (R&D Systems, Cat#404-ML-010/CF) at 1 ng/mL, to a final CCM volume of 200 µl/well. Stimulated lymphocytes were analysed in terms of

(11) Spleen-targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinomaEMBO molecular medicineOctober 11, 2023Wu M, Luo Z, Cai Z, Mao Q, Li Z, Li H, Zhang C, Zhang Y, Zhong A, Wu L, et al.medium containing 20 ng/ml murine GM‐CSF (R&D systems, 415‐ML‐020/CF), 10% FBS, and 10 ng/ml IL‐4 (404‐ML‐010/CF). Internalization of DNA nanovaccines by BMDCs was assessed by flow cytometry and CLSM. Immature BMDCs

(12) O-alg-THAM/gel hydrogels functionalized with engineered microspheres based on mesenchymal stem cell secretion recruit endogenous stem cells for cartilage repairBioactive materialsOctober 1, 2023Li Y, Li L, Wang M, Yang B, Huang B, Bai S, Zhang X, Hou N, Wang H, Yang Z, et al.anti-inflammatory phenotype induction, NR8383 macrophages were cultured in fusion medium containing 10 ng/ml IL-4 (404-ML-010/CF; R&D Systems, Minnesota, USA) in growth medium for 24 h. The obtained inflammatory and anti-inflammatory

(13) Conserved stromal-immune cell circuits secure B cell homeostasis and functionNature immunologyJuly 1, 2023Lütge M, De Martin A, Gil-Cruz C, Perez-Shibayama C, Stanossek Y, Onder L, Cheng HW, Kurz L, Cadosch N, Soneson C, et al.

(14) The RNA-binding protein hnRNP F is required for the germinal center B cell responseNature communicationsMarch 30, 2023Huang H, Li Y, Zhang G, Ruan GX, Zhu Z, Chen W, Zou J, Zhang R, Wang J, Ouyang Y, et al.

(15) Aiolos represses CD4(+) T cell cytotoxic programming via reciprocal regulation of T(FH) transcription factors and IL-2 sensitivityNature communicationsMarch 24, 2023Read KA, Jones DM, Pokhrel S, Hales EDS, Varkey A, Tuazon JA, Eisele CD, Abdouni O, Saadey A, Leonard MR, et al.

(16) SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarizationJournal of advanced researchMarch 1, 2023Lee JH, Lee SH, Lee EH, Cho JY, Song DK, Lee YJ, Kwon TK, Oh BC, Cho KW, Osborne TF, et al.

(17) Crosstalk between ILC2s and Th2 cells varies among mouse modelsCell reportsFebruary 28, 2023Gurram RK, Wei D, Yu Q, Butcher MJ, Chen X, Cui K, Hu G, Zheng M, Zhu X, Oh J, et al.

(18) Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitisNature communicationsFebruary 16, 2023Yang WL, Qiu W, Zhang T, Xu K, Gu ZJ, Zhou Y, Xu HJ, Yang ZZ, Shen B, Zhao YL, et al.

(19) Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone modelJournal of neuroinflammationFebruary 8, 2023Beckmann N, Neuhaus A, Zurbruegg S, Volkmer P, Patino C, Joller S, Feuerbach D, Doelemeyer A, Schweizer T, Rudin S, et al.

(20) Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunityCell reportsJanuary 31, 2023Liu J, Cheng Y, Zhang X, Chen Y, Zhu H, Chen K, Liu S, Li Z, Cao X.

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Recombinant Mouse IL-4 Protein, CF

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IL-4 Protein

IL-4 Protein

Recombinant Mouse IL-4 Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Mouse IL-4 Protein, CF from R&D Systems, a Bio-Techne Brand

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