Recombinant Human R-Spondin 4 Protein, CF 4575-RS-025/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human R-Spondin 4 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $529.00Supplier Page View Company Product Page
Catalog Number4575-RS-025/CF
SpeciesHuman
Size25 ug
Molecule NameR-Spondin 4
NCBI Full Gene NameR-spondin 4
NCBI Gene AliasesCRISTIN4, C20orf182
FormatLyophilized from a 0.2 µm filtered solution in PBS
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 30-36 kDa, reducing conditions
Theoretical: 24.1 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemCHO-derived Recombinant Human R-Spondin 4 Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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(1) R-spondins are BMP receptor antagonists in Xenopus early embryonic developmentNature communicationsNovember 4, 2020Lee H, Seidl C, Sun R, Glinka A, Niehrs C.

(4) RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signalingProceedings of the National Academy of Sciences of the United States of AmericaApril 1, 2014Carmon KS, Gong X, Yi J, Thomas A, Liu Q.

(5) RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancerNature communicationsJanuary 1, 2014Wu C, Qiu S, Lu L, Zou J, Li WF, Wang O, Zhao H, Wang H, Tang J, Chen L, et al.

(6) Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitorsNatureJuly 26, 2012Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, et al.

(7) ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive mannerNatureApril 29, 2012Hao HX, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, Lei H, Mickanin C, Liu D, Ruffner H, et al.

Recombinant Human R-Spondin 4 Protein, CF from R&D Systems, a Bio-Techne Brand