Osteopontin/OPN Protein 1433-OP-050/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemOsteopontin/OPN Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $297.00Supplier Page View Company Product Page
Catalog Number1433-OP-050/CF
SpeciesHuman
FormatLyophilized from a 0.2 µm filtered solution in PBS
Size50 ug
Molecule NameOsteopontin/OPN
NCBI Full Gene Namesecreted phosphoprotein 1
NCBI Gene AliasesBSPI, OPN, ETA-1, BNSP
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human Osteopontin (OPN) Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 50 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) General anaesthetics reduce acute lymphoblastic leukaemia malignancies in vitro and in vivo via CXCR4 and osteopontin mediated mechanismsF1000ResOctober 9, 2025Cui Jiang, Sara Gonzalez-Anton, Xiaomeng Li, Emma Mi, Lingzhi Wu, Hailin Zhao, Ge Zhang, Aiping Lu, Cristina Lo Celso, Daqing Mapre-treated with propofol and sevoflurane with respective concentrations. Recombinant human OPN (R&D systems, 1433-OP-050/CF) was thrombin-cleaved by incubating 24 μg recombinant full length human OPN in 20 mM Tris-HCL (pH7.6),

(2) Progranulin enhances the engraftment of transplanted human iPS cell-derived cerebral neuronsStem Cells Translational MedicineNovember 12, 2024Keitaro Yamagami, Bumpei Samata, Daisuke Doi, Ryosuke Tsuchimochi, Tetsuhiro Kikuchi, Naoya Amimoto, Megumi Ikeda, Koji Yoshimoto, Jun TakahashiUSA), 250, 500 mg/dL; lysozyme, LYZ (ab158839; abcam, Cambridge, UK), 250, 500 mg/dL; osteopontin, OPN (1433-OP-050 CF; R&D Systems, Minneapolis, MN, USA), 250, 500 mg/dL, progranulin, PGRN (2420-PG-050; R&D Systems, Minneapolis,

(3) Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritisArthritis research & therapyFebruary 17, 2023Umemoto A, Kuwada T, Murata K, Shiokawa M, Ota S, Murotani Y, Itamoto A, Nishitani K, Yoshitomi H, Fujii T, et al.methods Reagents and antibodies Recombinant osteopontin was purchased from R&D Systems (Minneapolis, MN, USA, #1433-OP-050/CF), ACROBiosystems (Newark, DE, #OPN-H5227), and Abcam (Cambridge, UK, #ab92964, #ab281819). Fibronectin,

(4) Differential Modulation of Human M1 and M2 Macrophage Activity by ICOS-Mediated ICOSL TriggeringInternational journal of molecular sciencesFebruary 2, 2023Gigliotti CL, Dianzani C, Stoppa I, Monge C, Sutti S, Sblattero D, Puricelli C, Rolla R, Dianzani U, Boggio E.

(5) Osteopontin Exacerbates High-Fat Diet-Induced Metabolic Disorders in a Microbiome-Dependent MannermBioDecember 20, 2022Chen J, Zeng P, Gong L, Zhang X, Ling Z, Bi K, Shi F, Wang K, Zhang Q, Jiang J, et al.

(6) Paper-based aptasensor for colorimetric detection of osteopontinAnalytica chimica actaMarch 15, 2022Pereira AC, Moreira FTC, Rodrigues LR, Sales MGF.

(7) General anaesthetics reduce acute lymphoblastic leukaemia malignancies in vitro and in vivovia CXCR4 and osteopontin mediated mechanismsF1000ResearchJanuary 1, 2022Jiang C, Gonzalez-Anton S, Li X, Mi E, Wu L, Zhao H, Zhang G, Lu A, Lo Celso C, Ma D.pre-treated with propofol and sevoflurane with respective concentrations. Recombinant human OPN (R&D systems, 1433-OP-050/CF) was thrombin-cleaved by incubating 24 μg recombinant full length human OPN in 20 mM Tris-HCL (pH7.6),

(8) Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damageNature communicationsNovember 18, 2021Martín-Alonso M, Iqbal S, Vornewald PM, Lindholm HT, Damen MJ, Martínez F, Hoel S, Díez-Sánchez A, Altelaar M, Katajisto P, et al.

(9) Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8The Journal of biological chemistryNovember 1, 2021Santamaria S, Martin DR, Dong X, Yamamoto K, Apte SS, Ahnström J.

(10) Lipid-injured hepatocytes release sOPN to improve macrophage migration via CD44 engagement and pFak-NFκB signalingCytokineJune 1, 2021Jiang X, Zhang F, Ji X, Dong F, Yu H, Xue M, Qiu Y, Yang F, Hu X, Bao Z.

(11) The interaction between cancer associated fibroblasts and tumor associated macrophages via the osteopontin pathway in the tumor microenvironment of hepatocellular carcinomaOncotargetFebruary 16, 2021Tokuda K, Morine Y, Miyazaki K, Yamada S, Saito Y, Nishi M, Tokunaga T, Ikemoto T, Imura S, Shimada M.

(12) Absence of nuclear receptors LXRs impairs immune response to androgen deprivation and leads to prostate neoplasiaPLoS biologyDecember 1, 2020Bousset L, Septier A, Bunay J, Voisin A, Guiton R, Damon-Soubeyrant C, Renaud Y, De Haze A, Sapin V, Fogli A, et al.10% FBS RPMI medium (Invitrogen). Cells were treated with recombinant human OPN protein (R&D systems, 1433-OP-050/ CF, Minneapolis, Minnesota) at concentrations of 0.1, 1, or 10 mg/mL or PBS as negative control for 24

(13) Effect of Calcium Chloride Hydrothermal Treatment of Titanium on Protein, Cellular, and Bacterial Adhesion PropertiesJournal of clinical medicineAugust 13, 2020Haraguchi T, Ayukawa Y, Shibata Y, Takeshita T, Atsuta I, Ogino Y, Yasunami N, Yamashita Y, Koyano K.

(14) NK cells induce hepatic ER stress to promote insulin resistance in obesity through osteopontin productionJournal of leukocyte biologyApril 1, 2020Wu J, Wu D, Zhang L, Lin C, Liao J, Xie R, Li Z, Wu S, Liu A, Hu W, et al.

(15) Co-culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxiaJournal of cellular and molecular medicineMarch 1, 2020Sadaghianloo N, Contenti J, Dufies M, Parola J, Rouleau M, Lee S, Peyron JF, Fabbri L, Hassen-Khodja R, Pouysségur J, et al.

(16) Development of a novel and rapid measurement system for growth differentiation factor-15, progranulin, and osteopontin in uterine sarcomaEndocrine journalJanuary 28, 2020Maeno M, Mizutani T, Tsuyoshi H, Yamada S, Ishikane S, Kawabe S, Nishimura K, Yamada M, Miyamoto K, Yoshida Y.

(17) Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancereLifeMay 28, 2019Adams CR, Htwe HH, Marsh T, Wang AL, Montoya ML, Subbaraj L, Tward AD, Bardeesy N, Perera RM.to manufacturers protocol. For experiments where exogenous ligand was added, recombinant human OPN (1433-OP-050/CF; R and D Systems) was added at 1 mg/mL and cells assayed 2–3 days later. Drug treatment Cells were

(18) Correlation of OPN gene expression with proliferation and apoptosis of ovarian cancer cells and prognosis of patientsOncology lettersMarch 1, 2019Hu H, Liu Z, Liu C.5% BSA at 20°C for 1.5 h. The primary mouse anti-human antibody of OPN (dilution, 1:2,000; cat. no. 1433-OP-050/CF; R&D Systems, Inc.) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) monoclonal antibody (dilution,

(19) Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic targetThe Journal of clinical investigationJanuary 2, 2019Wei J, Marisetty A, Schrand B, Gabrusiewicz K, Hashimoto Y, Ott M, Grami Z, Kong LY, Ling X, Caruso H, et al.

(20) A multiplex immunoassay of serum biomarkers for the detection of uveal melanomaClinical proteomicsJanuary 1, 2019Song J, Merbs SL, Sokoll LJ, Chan DW, Zhang Z.

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Osteopontin/OPN Protein

Osteopontin/OPN Protein

Osteopontin/OPN Protein

Osteopontin/OPN Protein

Osteopontin/OPN Protein

Osteopontin/OPN Protein from R&D Systems, a Bio-Techne Brand

Description

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (42)

Reviews

Osteopontin/OPN Protein from R&D Systems, a Bio-Techne Brand

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