Description
KillerTRAIL™ (soluble) (human), (recombinant) is an enhanced ligand that utilizes the proprietary Killer™ linker peptide that promotes trimerization to form a more stable oligomer. It has been well established that signals transmitted via TNF ligands and receptors are critical in mediating inflammation, cancer, and immunity. This has led to drug development aiming to either reduce or enhance receptor response. One limitation in this process is the inherent instability of recombinant ligands and their inability to effectively mimic the natural clustering of TNF receptors on the cell surface required for immune activation. Oligomerization of TNF ligands such as KillerTRAIL™ has been shown to improve stability and significantly enhance immune activation compared to recombinant ligands alone