Fig 1: High SETD5 Expression Correlates with downregulation of Pro-Apoptotic Genes in Glioblastoma. (A) Heat map showing gene expression of various apoptotic genes in patient tumor samples in High SETD5 versus Low SETD5 expression-data obtained from Geo Dataset (GDS3885, GDS4467). (B) Co-expression analysis of SETD5 and TNFSF10 from cBioportal database (Spearman r = −0.17, p = 0.0456). (C) Co-expression analysis of SETD5 and NFKB1 from cBioportal database (Spearman r = 0.37, p = 4.657e-6). (D) mRNA expression of SETD5 after siRNA transfection in U87MG and LN229 cell lines. (E) Western blot analysis of SETD5 (100 kDa isoform) and NFΚβ in dose dependent TRAIL treatment in U87MG and LN229 cell lines.