Recombinant Human Klotho beta Protein, CF 5889-KB-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Klotho beta Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $595.00Supplier Page View Company Product Page
Catalog Number5889-KB-050
FormatSupplied as a 0.2 µm filtered solution in PBS, Glycerol and EDTA
SpeciesHuman
Size50 ug
Molecule NameKlotho beta
NCBI Full Gene Nameklotho beta
NCBI Gene AliasesBKL
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 113 - 125 kDa, reducing conditions
Theoretical: 110 kDa
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human Klotho beta Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after opening

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Heating-mediated purification of active FGF21 and structure-based design of its variant with enhanced potencyScientific reportsJanuary 18, 2023Jung YE, Lee KW, Cho JH, Bae DW, Jeong BG, Jung YJ, Park SB, An YJ, Kim K, Lee GS, et al.BR100050; Cytiva) at surface densities of approximately 700–900 response units (RU). Human β-Klotho (cat# 5889-KB-050; R&D Systems) was diluted as 2.5-fold series (250, 100, 40, 16, 6.4, 2.56, 1.024, and 0 nM) in running

(2) FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetesScientific reportsMay 5, 2022Yanucil C, Kentrup D, Li X, Grabner A, Schramm K, Martinez EC, Li J, Campos I, Czaya B, Heitman K, et al.(2539-FG-025/CF, R&D Systems, United States), mouse FGF21 (8409-FG-025/CF, R&D Systems), human soluble β-klotho (5889-KB-050/CF, R&D Systems), human FGFR1c (658-FR-050, R&D Systems); human FGFR2c (712-FR-050, R&D Systems); human

(3) A novel antibody for the detection of alternatively spliced secreted KLOTHO isoform in human plasmaPloS oneJanuary 1, 2021Jadhav S, Tripathi S, Chandrekar A, Waikar SS, Hsiao LL.Novus Biologicals) following the manufacturers protocol. Reagents Recombinant beta-Klotho protein (5889-KB-050, R&D systems), Recombinant Human TGFbeta 1 protein (240-B-002, R&D systems), Recombinant Human IL-6 protein

(4) Curtailing FGF19's mitogenicity by suppressing its receptor dimerization abilityProceedings of the National Academy of Sciences of the United States of AmericaNovember 17, 2020Niu J, Zhao J, Wu J, Qiao G, Gu J, Zhou C, Li Q, Ying L, Wang D, Lin H, et al.

(5) βKlotho is identified as a target for theranostics in non-small cell lung cancerTheranosticsJanuary 1, 2019Li F, Li X, Li Z, Ji W, Lu S, Xia W.

(6) Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificityMolecular metabolismJuly 1, 2018Agrawal A, Parlee S, Perez-Tilve D, Li P, Pan J, Mroz PA, Kruse Hansen AM, Andersen B, Finan B, Kharitonenkov A, et al.

(7) The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cellsCell communication and signaling : CCSMarch 24, 2015Gutknecht M, Geiger J, Joas S, Dörfel D, Salih HR, Müller MR, Grünebach F, Rittig SM.

(8) Fibroblast Growth Factor 21 Improves Insulin Sensitivity and Synergizes with Insulin in Human Adipose Stem Cell-Derived (hASC) AdipocytesPLoS ONENovember 3, 2014Darwin V. Lee, Dongmei Li, Qingyun Yan, Yimin Zhu, Bryan Goodwin, Roberto Calle, Martin B. Brenner, Saswata Talukdarpathway. Methods Recombinant Proteins Recombinant human beta-klotho (KLB) was purchased from R&D Systems (5889-KB-050). Insulin was purchased from Sigma (I0516). Wild type FGF21 and FGF21-dC10 were generated in house. Human

(9) Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitorsNatureJuly 26, 2012Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, et al.

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Klotho beta Protein

Klotho beta Protein

Klotho beta Protein

Klotho beta Protein

Klotho beta Protein

Recombinant Human Klotho beta Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human Klotho beta Protein, CF from R&D Systems, a Bio-Techne Brand

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