Recombinant Human TrkB Fc Chimera Protein, CF 688-TK-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human TrkB Fc Chimera Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $504.00Supplier Page View Company Product Page
Catalog Number688-TK-100
SpeciesHuman
FormatLyophilized from a 0.2 µm filtered solution in PBS
Size100 ug
Molecule NameTrkB
NCBI Full Gene Nameneurotrophic receptor tyrosine kinase 2
NCBI Gene AliasesEIEE58, TRKB, trk-B, OBHD, DEE58, GP145-TrkB
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 120 kDa-130 kDa, reducing conditions
Theoretical: 71.7 kDa (monomer)
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human TrkB Fc Chimera Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic physiology in Alzheimer's diseaseMolecular therapy : the journal of the American Society of Gene TherapyOctober 2, 2024Fonseca-Gomes J, Costa-Coelho T, Ferreira-Manso M, Inteiro-Oliveira S, Vaz SH, Alemãn-Serrano N, Atalaia-Barbacena H, Ribeiro-Rodrigues L, Ramalho RM, Pinto R, et al.

(2) Boosting BDNF in muscle rescues impaired axonal transport in a mouse model of DI-CMTC peripheral neuropathybioRxiv : the preprint server for biologyMarch 11, 2024Rhymes ER, Simkin RL, Qu J, Villarroel-Campos D, Surana S, Tong Y, Shapiro R, Burgess RW, Yang XL, Schiavo G, et al.

(3) Different activity patterns control various stages of Reelin synthesis in the developing neocortexCerebral cortex (New York, N.Y. : 1991)July 24, 2023Engeroff K, Warm D, Bittner S, Blanquie O.7,8-Dihydroxyflavone (DHF, Tocris, Cat No: 3826), 0.3 μg/mL recombinant human TrkB-Fc (R&D Systems, Cat No: 688-TK-100), 1 μg/mL recombinant Reelin (R&D Systems, Cat No 3820-MR-025). For control conditions, the same volume

(4) Psychedelics promote plasticity by directly binding to BDNF receptor TrkBNature neuroscienceJune 1, 2023Moliner R, Girych M, Brunello CA, Kovaleva V, Biojone C, Enkavi G, Antenucci L, Kot EF, Goncharuk SA, Kaurinkoski K, et al.effects of pretreatment with ketanserin (100 nM), M100907 (100 nM) or TRKB.FC (200 ng ml−1, R&D Systems, 688-TK-100) (ref. 74) on TrkB dimerization induced by LSD or BDNF (0.1 ng ml−1 or 10 ng ml−1). Ketanserin, M100907

(5) Inhibition of Nogo-A rescues synaptic plasticity and associativity in APP/PS1 animal model of Alzheimer's diseaseSeminars in cell & developmental biologyApril 1, 2023Pavon MV, Navakkode S, Wong LW, Sajikumar S.

(6) BDNF signaling in correlation-dependent structural plasticity in the developing visual systemPLoS biologyApril 1, 2023Kutsarova E, Schohl A, Munz M, Wang A, Zhang YY, Bilash OM, Ruthazer ES.

(7) Brain-Derived Neurotrophic Factor Is Indispensable to Continence Recovery after a Dual Nerve and Muscle Childbirth Injury ModelInternational journal of molecular sciencesMarch 5, 2023Balog BM, Deng K, Askew T, Hanzlicek B, Kuang M, Damaser MS.

(8) Trophic factor BDNF inhibits GABAergic signaling by facilitating dendritic enrichment of SUMO E3 ligase PIAS3 and altering gephyrin scaffoldThe Journal of biological chemistryMay 1, 2022Thirouin ZS, Figueiredo M, Hleihil M, Gill R, Bosshard G, McKinney RA, Tyagarajan SK.Alomone Labs #N-260), or NT-4 (10 ng/ml, Alomone Labs #N-270) and/or rh TrKB-Fc (1 μg/ml, R&D Systems #688-TK-100). Otherwise, the cells were treated overnight with ERK 1/2 inhibitor: PD98059 (25 μM/ml, Calbiochem#513000)

(9) Inhibiting BDNF Signaling Upregulates Hippocampal H3K9me3 in a Manner Dependent On In Vitro Aging and Oxidative StressFrontiers in AgingApril 28, 2022Andra Ionescu-Tucker, Liqi Tong, Nicole C. Berchtold, Carl W. CotmanH2O2 diluted in treatment media for 5 min or 200 μM H2O2 for 4 h. Lyophilized TrkB-Fc (R&D Systems, 688-TK-100) was diluted to a stock solution of 100 μg/ml in sterile PBS. Cultures were treated with 1 μg/ml TrkB-Fc

(10) NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injuryCell reportsMarch 29, 2022Zhou J, Geng Y, Su T, Wang Q, Ren Y, Zhao J, Fu C, Weber M, Lin H, Kaminker JS, et al.

(11) Neuroligin-1 mediates presynaptic maturation through brain-derived neurotrophic factor signalingBMC biologySeptember 27, 2021Petkova-Tuffy A, Gödecke N, Viotti J, Korte M, Dresbach T.reconstitute BDNF) was added to the cell medium in the control condition. TrkB-Fc (R&D Systems, cat. No. 688-TK-100) dissolved in sterile PBS was added at a final concentration of 4 μg/mL to inhibit the TrkB receptor

(12) A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strengthCell reportsAugust 3, 2021Horvath PM, Chanaday NL, Alten B, Kavalali ET, Monteggia LM.# 110HG100 "Recombinant Human TrkB Fc Chimera Protein, CF (BDNF scavenger)",R&D Systems,Catalog # 688-TK-100 "1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f] quinoxaline-7-sulfonamide disodium salt hydrate (NBQX)",AbCam,Catalog

(13) Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neuronsScientific reportsJuly 22, 2021Zhang Y, Smolen PD, Cleary LJ, Byrne JH.

(14) Environmental enrichment implies GAT-1 as a potential therapeutic target for stroke recoveryTheranosticsJanuary 1, 2021Lin Y, Yao M, Wu H, Wu F, Cao S, Ni H, Dong J, Yang D, Sun Y, Kou X, et al.

(15) The Rab5-Rab11 Endosomal Pathway is Required for BDNF-Induced CREB Transcriptional Regulation in Hippocampal NeuronsThe Journal of neuroscience : the official journal of the Society for NeuroscienceOctober 14, 2020González-Gutiérrez A, Lazo OM, Bronfman FC.

(16) Fingolimod Modulates Dendritic Architecture in a BDNF-Dependent MannerInternational journal of molecular sciencesApril 27, 2020Patnaik A, Spiombi E, Frasca A, Landsberger N, Zagrebelsky M, Korte M.

(17) Novel metabolic role for BDNF in pancreatic β-cell insulin secretionNature communicationsApril 23, 2020Fulgenzi G, Hong Z, Tomassoni-Ardori F, Barella LF, Becker J, Barrick C, Swing D, Yanpallewar S, Croix BS, Wess J, et al.

(18) Exercise training modulates glutamic acid decarboxylase-65/67 expression through TrkB signaling to ameliorate neuropathic pain in rats with spinal cord injuryMolecular painJanuary 1, 2020Li X, Wang Q, Ding J, Wang S, Dong C, Wu Q.

(19) Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1eLifeAugust 21, 2019Leanne M Holt, Raymundo D Hernandez, Natasha L Pacheco, Beatriz Torres Ceja, Muhannah Hossain, Michelle L Olsenreagent,Gapdh,ThermoFisher Scientific,Cat#4352339E, "Peptide, recombinant protein",TrkB-Fc,R and D Systems,Cat#688-TK-100,2 ug "Peptide, recombinant protein",BDNF,Promega,Cat# G1491, "Chemical compound, drug",(z)−4-hydroxytamoxifen;

(20) Blocking of BDNF-TrkB signaling inhibits the promotion effect of neurological function recovery after treadmill training in rats with spinal cord injurySpinal cordJanuary 1, 2019Li X, Wu Q, Xie C, Wang C, Wang Q, Dong C, Fang L, Ding J, Wang T.

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Recombinant Human TrkB Fc Chimera Protein, CF

TrkB Fc Chimera Protein

TrkB Fc Chimera Protein

TrkB Fc Chimera Protein

TrkB Fc Chimera Protein

Recombinant Human TrkB Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human TrkB Fc Chimera Protein, CF from R&D Systems, a Bio-Techne Brand

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