Anti-ABCG2 antibodies are used in the immunodetection of the protein ATP binding cassette subfamily G member 2 (Junior blood group). In humans, the canonical protein has a reported length of 655 amino acid residues and a mass of 72.3 kDa. Its subcellular localization is in the mitochondria and cell membrane. Up to 2 different isoforms have been reported for this protein. It is reported to be highly expressed in the placenta. A member of the ABCG protein family, ABCG2 is known to be involved with the metabolism of lipids and the transport of ions. Post-translational modifications have been described, including N-glycosylation and phosphorylation. The ABCG2 marker can be used to identify Brain Vascular Non-Neuronal Cells.* Synonyms for this target antigen include ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, CDw388, and ABC15. ABCG2 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4