The Biocompare Inhibitor Search Tool lets researchers browse thousands of compounds by searching by inhibitor name or by its target enzyme. Enter the inhibitor name under "Keywords" or enter the target protein name under "Inhibitor Target.” You may also check the appropriate boxes to further narrow your search.
c-Jun N-terminal kinases (JNKs) are members of the MAPK family that play a role in T-cell differentiation and apoptosis in response to stress stimuli. There are ten JNK isoforms derived from three different genes (JNK1, JNK2, and JNK 3). JNK1 and JNK2 can be found in cells throughout the body, while JNK3 is primarily found in the brain. Inhibition of JNK is seen as a potential target for treatment of cancer, neurodegenerative diseases, inflammatory disorders, and insulin resistance. There are a number of small-molecule inhibitors currently available that act on JNK, though pinning down inhibitors with higher specificity and potency remains an active area of research for pharmaceutical companies.