The following checkpoint kinase 1 ELISA kits are useful research tools for the measurement of checkpoint kinase 1 in biological samples. In humans this protein is encoded by the CHEK1 gene. This protein is reported to be a serine/threonine-protein kinase, which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. The canonical protein structure is reported to have an amino acid length of 476 residues, a mass of 54.4 kDa, and is a member of the CAMK Ser/Thr protein kinase protein family. Its subcellular location is known to be in the nucleus and cytoplasm. In addition, it is found to be widely expressed with the most abundant expression in thymus, testis, small intestine and colon. As many as 3 protein isoforms have been reported. In certain instances, it is also post-translationally ubiquitinated, cleaved and phosphorylated. This protein may also be known as serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, Checkpoint, S. pombe, homolog of, 1, Chk1-S, cell cycle checkpoint kinase, and CHK1.
There are checkpoint kinase 1 ELISA kits that can detect a target at concentrations as low as 0.15 ng/mL and as high as 10 ng/mL. Use the search filters to narrow your search and click on the ELISA kits below for more detailed information, such as reactivity and assay sensitivity.