TIGIT ELISA kits are immunoassay tools for the measurement of the protein T cell immunoreceptor with Ig and ITIM domains, which is encoded by the TIGIT gene in humans. Functionally, this protein is known to bind with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. The canonical protein structure is reported to have an amino acid sequence of 244 residues and a mass of 26.3 kDa. It is known to be localized in the cell membrane and is reported to be expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells. As many as 2 protein isoforms have been reported. The protein has been noted to be post-translationally glycosylated. Other alias names for this target include V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain containing 3, V-set and transmembrane domain-containing protein 3, and V-set and immunoglobulin domain containing 9.
There are TIGIT ELISA kits that can detect a target at concentrations as low as 15.625 pg/mL and as high as 100 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.