TET1 ELISA kits are immunoassay tools for the measurement of the protein tet methylcytosine dioxygenase 1, which is encoded by the TET1 gene in humans. Functionally, this protein is a reported dioxygenase that plays a key role in active DNA demethylation, by catalyzing the sequential oxidation of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). The canonical protein structure is reported to have an amino acid length of 2136 residues, a mass of 235.3 kDa, and is a member of the TET protein family. It is known to be localized in the nucleus and is reported to be expressed in fetal heart, lung and brain, and in adult skeletal muscle, thymus and ovary. As many as 4 protein isoforms have been reported. The protein has been noted to be post-translationally glycosylated and ubiquitinated. Other alias names for this target include CXXC finger 6, CXXC zinc finger 6, CXXC-type zinc finger protein 6, leukemia-associated protein with a CXXC domain, and methylcytosine dioxygenase TET1.
The detection range for different TET1 ELISA kits can vary, with some assays measuring target concentrations as low as 0.156 ng/mL and as high as 10 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.