ATXN3 ELISA kits are immunoassay tools for the measurement of the protein ataxin 3, which is encoded by the ATXN3 gene in humans. Functionally, this protein is known to be a deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. The canonical protein structure is reported to have an amino acid sequence of 361 residues and a mass of 41.3 kDa. It is known to be localized in the nucleus and is ubiquitously expressed across many tissue types. As many as 5 protein isoforms have been reported. The protein has been noted to be post-translationally ubiquitinated. The ATXN3 gene has been associated with the disease, Spinocerebellar ataxia. Other alias names for this target include ATX3, JOS, MJD, MJD1, SCA3, Machado-Joseph disease protein 1, josephin, and AT3.
The detection range for different ATXN3 ELISA kits can vary, with some assays measuring target concentrations as low as 0.156 ng/mL and as high as 20 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.