These PION ELISA kits are immunodetection tools for measuring the levels of PION in biological samples. PION is an alias of the human GSAP gene, which encodes the protein, gamma-secretase activating protein. The protein is a reported regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The GSAP protein is 854 amino acid residues in length and 97.8 kilodaltons in mass. However, as many as 4 protein isoforms have been identified. It is localized to the golgi of the cell. In terms of tissue specificity, it is widely expressed across many tissue types.
There are PION ELISA kits that can detect a target at concentrations as low as 1.56 ng/mL and as high as 100 ng/mL. Click on the following ELISA kits for more detailed information, including target reactivity and assay sensitivity.