ERBB4 ELISA kits are immunoassay tools for the measurement of the protein erb-b2 receptor tyrosine kinase 4, which is encoded by the ERBB4 gene in humans. Functionally, this protein is reported to be a tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. The canonical protein structure is reported to have an amino acid length of 1308 residues, a mass of 146.8 kDa, and is a member of the Tyr protein kinase protein family. It is known to be localized in the cell membrane and is reported be expressed at highest levels in the brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. As many as 4 protein isoforms have been reported. The protein has been noted to be post-translationally glycosylated, ubiquitinated, cleaved and phosphorylated. The ERBB4 gene has been associated with the disease, Amyotrophic lateral sclerosis. Other alias names for this target include HER4, p180erbB4, receptor tyrosine-protein kinase erbB-4, avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4, and ALS19.
Some ERBB4 ELISA kits can detect targets at levels as low as 31.2 pg/mL and as high as 50 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.