CRBN ELISA kits are immunoassay tools for the measurement of the protein cereblon, which is encoded by the CRBN gene in humans. Functionally, this protein is reported to be a substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 or ILF2. The canonical protein structure is reported to have an amino acid length of 442 residues, a mass of 50.5 kDa, and is a member of the CRBN protein family. It is known to be localized in the membrane, nucleus, and cytoplasm and is widely expressed across many tissue types. As many as 2 protein isoforms have been reported. The protein has been noted to be post-translationally ubiquitinated. The CRBN gene has been associated with the disease, Intellectual developmental disorder. Other alias names for this target include MRT2A, protein cereblon, protein x 0001, and MRT2.
The detection range for different CRBN ELISA kits can vary, with some assays measuring target concentrations as low as 0.1 ng/mL and as high as 40 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.