COL17A1 ELISA kits are immunoassay tools for the measurement of the protein collagen type XVII alpha 1 chain, which is encoded by the COL17A1 gene in humans. Functionally, this protein is believed to play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane; The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. The canonical protein structure is reported to have an amino acid sequence of 1497 residues and a mass of 150.4 kDa. It is known to be localized in the extracellular matrix and is notably expressed in skin. As many as 2 protein isoforms have been reported. The protein has been noted to be post-translationally glycosylated, cleaved and phosphorylated. The COL17A1 gene has been associated with the disease, Epidermolysis bullosa. Other alias names for this target include BP180, BPA-2, BPAG2, ERED, JEB4, LAD-1, collagen alpha-1(XVII) chain, and BA16H23.2.
The detection range for different COL17A1 ELISA kits can vary, with some assays measuring target concentrations as low as 0.156 ng/mL and as high as 200 ng/mL. Click on the products below for more detailed ELISA kit information, such as target reactivity and assay sensitivity.