The following Caspase 8 ELISA kits are useful research tools for the measurement of caspase 8 in biological samples. In humans this protein is encoded by the CASP8 gene. This protein is reported to be a thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (By similarity). The canonical protein structure is reported to have an amino acid length of 479 residues, a mass of 55.4 kDa, and is a member of the Peptidase C14A protein family. Its subcellular location is known to be in the nucleus and cytoplasm. As many as 9 protein isoforms have been reported. In certain instances, it is also post-translationally cleaved and phosphorylated. The gene encoding this protein has been associated with the disease, Caspase-8 deficiency. This protein may also be known as CAP4, FLICE, MACH, MCH5, FADD-homologous ICE/CED-3-like protease, and ALPS2B.
The detection range for different Caspase 8 ELISA kits can vary, with some assays measuring target concentrations as low as 20 ng/L and as high as 90 ng/mL. Use the search filters to narrow your search and click on the ELISA kits below for more detailed information, such as reactivity and assay sensitivity.